Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Jean- François Trempe"'
Autor:
Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows R
Externí odkaz:
https://doaj.org/article/b55f87d3a9934780bd5addb22763e47c
Autor:
Véronique Sauvé, Eric Stefan, Nathalie Croteau, Thomas Goiran, Rayan Fakih, Nupur Bansal, Adelajda Hadzipasic, Jing Fang, Paramasivam Murugan, Shimin Chen, Edward A. Fon, Warren D. Hirst, Laura F. Silvian, Jean-François Trempe, Kalle Gehring
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Mutations in parkin and PINK1 cause early-onset Parkinson’s disease (EOPD). The ubiquitin ligase parkin is recruited to damaged mitochondria and activated by PINK1, a kinase that phosphorylates ubiquitin and the ubiquitin-like domain of pa
Externí odkaz:
https://doaj.org/article/df3c73716eab4203816680f5d6146ade
Autor:
Emily Banks, Vincent Francis, Sheng-Jia Lin, Fares Kharfallah, Vladimir Fonov, Maxime Lévesque, Chanshuai Han, Gopinath Kulasekaran, Marius Tuznik, Armin Bayati, Reem Al-Khater, Fowzan S. Alkuraya, Loukas Argyriou, Meisam Babaei, Melanie Bahlo, Behnoosh Bakhshoodeh, Eileen Barr, Lauren Bartik, Mahmoud Bassiony, Miriam Bertrand, Dominique Braun, Rebecca Buchert, Mauro Budetta, Maxime Cadieux-Dion, Daniel G. Calame, Heidi Cope, Donna Cushing, Stephanie Efthymiou, Marwa Abd Elmaksoud, Huda G. El Said, Tawfiq Froukh, Harinder K. Gill, Joseph G. Gleeson, Laura Gogoll, Elaine S.-Y. Goh, Vykuntaraju K. Gowda, Tobias B. Haack, Mais O. Hashem, Stefan Hauser, Trevor L. Hoffman, Jacob S. Hogue, Akimoto Hosokawa, Henry Houlden, Kevin Huang, Stephanie Huynh, Ehsan G. Karimiani, Silke Kaulfuß, G. Christoph Korenke, Amy Kritzer, Hane Lee, James R. Lupski, Elysa J. Marco, Kirsty McWalter, Arakel Minassian, Berge A. Minassian, David Murphy, Juanita Neira-Fresneda, Hope Northrup, Denis M. Nyaga, Barbara Oehl-Jaschkowitz, Matthew Osmond, Richard Person, Davut Pehlivan, Cassidy Petree, Lynette G. Sadleir, Carol Saunders, Ludger Schoels, Vandana Shashi, Rebecca C. Spillmann, Varunvenkat M. Srinivasan, Paria N. Torbati, Tulay Tos, Undiagnosed Diseases Network, Maha S. Zaki, Dihong Zhou, Christiane Zweier, Jean-François Trempe, Thomas M. Durcan, Ziv Gan-Or, Massimo Avoli, Cesar Alves, Gaurav K. Varshney, Reza Maroofian, David A. Rudko, Peter S. McPherson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Developmental and epileptic encephalopathies (DEEs) feature altered brain development, developmental delay and seizures, with seizures exacerbating developmental delay. Here we identify a cohort with biallelic variants in DENND5A, encoding a
Externí odkaz:
https://doaj.org/article/67b9cc39749f4c32a8e5662c1d902770
Autor:
Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A. Bustillos, Wolfdieter Springer, Fabienne C. Fiesel, Jean-François Trempe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Mutations in PINK1 and Parkin cause early-onset Parkinson’s Disease (PD). PINK1 is a kinase which functions as a mitochondrial damage sensor and initiates mitochondrial quality control by accumulating on the damaged organelle. There, it ph
Externí odkaz:
https://doaj.org/article/223ccc106f0e46d08ec3d09d3720a751
Autor:
Gabriel Torrealba-Acosta, Eric Yu, Tanya Lobo-Prada, Javier Ruíz-Martínez, Ana Gorostidi-Pagola, Ziv Gan-Or, Kenneth Carazo-Céspedes, Jean-François Trempe, Ignacio F. Mata, Jaime Fornaguera-Trías
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ec97e38b4e224e7c8da58d8fff9fcb50
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284541 (2023)
Mitochondrial dysfunction is implicated in a wide array of human diseases ranging from neurodegenerative disorders to cardiovascular defects. The coordinated localization and import of proteins into mitochondria are essential processes that ensure mi
Externí odkaz:
https://doaj.org/article/1f35c17f84f04b16ad2e6a2d56eb85ea
Autor:
Mehrdad A. Estiar, Etienne Leveille, Dan Spiegelman, Nicolas Dupre, Jean-François Trempe, Guy A. Rouleau, Ziv Gan‐Or
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract Background Hereditary spastic paraplegias (HSP) are neurodegenerative disorders characterized by lower limb spasticity and weakness, with or without additional symptoms. Mutations in ATP13A2, known to cause Kufor–Rakeb syndrome (KRS), have
Externí odkaz:
https://doaj.org/article/11cf0d4baf34423992a35dc993d9af9a
Autor:
Ahmad Abdelzaher Zaki Khalifa, Muneyoshi Ichikawa, Daniel Dai, Shintaroh Kubo, Corbin Steven Black, Katya Peri, Thomas S McAlear, Simon Veyron, Shun Kai Yang, Javier Vargas, Susanne Bechstedt, Jean-François Trempe, Khanh Huy Bui
Publikováno v:
eLife, Vol 9 (2020)
Microtubules are cytoskeletal structures involved in stability, transport and organization in the cell. The building blocks, the α- and β-tubulin heterodimers, form protofilaments that associate laterally into the hollow microtubule. Microtubule al
Externí odkaz:
https://doaj.org/article/1023902bdd32453c86fbf2f322e2c9a6
Autor:
Shahriar M. Khan, Ryan D. Martin, Andrew Bayne, Darlaine Pétrin, Kyla Bourque, Jace Jones-Tabah, Celia Bouazza, Jacob Blaney, Jenny Lau, Kimberly Martins-Cannavino, Sarah Gora, Andy Zhang, Sarah MacKinnon, Phan Trieu, Paul B.S. Clarke, Jean-François Trempe, Jason C. Tanny, Terence E. Hébert
Publikováno v:
J Biol Chem
Gβγ subunits mediate many different signaling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ signaling, we investigated the functional role of Gβγ signaling in the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0c1bfa2516edf92669128fd1b416ba
https://europepmc.org/articles/PMC10060754/
https://europepmc.org/articles/PMC10060754/
Autor:
Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon
Publikováno v:
eLife, Vol 7 (2018)
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnove
Externí odkaz:
https://doaj.org/article/2a20fbdecc3a4cceb1d095ef6f8f8d3b