Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jean Y.H. Yang"'
Autor:
Su Yin Lim, Yingxin Lin, Jenny H. Lee, Bernadette Pedersen, Ashleigh Stewart, Richard A. Scolyer, Georgina V. Long, Jean Y.H. Yang, Helen Rizos
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105308- (2024)
Summary: Background: Melanoma is a heterogeneous cancer influenced by the plasticity of melanoma cells and their dynamic adaptations to microenvironmental cues. Melanoma cells transition between well-defined transcriptional cell states that impact tr
Externí odkaz:
https://doaj.org/article/0f6bc570850d4b089ffba99d3b6434f7
Autor:
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y.H. Yang, Ellis Patrick
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106633- (2023)
Summary: Cardiovascular disease remains a leading cause of mortality with an estimated half a billion people affected in 2019. However, detecting signals between specific pathophysiology and coronary plaque phenotypes using complex multi-omic discove
Externí odkaz:
https://doaj.org/article/1e3bd3bd2ce74709add12efe4fe44c71
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S19, Pp 1-12 (2019)
Abstract Background Differences in cell-type composition across subjects and conditions often carry biological significance. Recent advancements in single cell sequencing technologies enable cell-types to be identified at the single cell level, and a
Externí odkaz:
https://doaj.org/article/15daccdcd3d2470aa5d6d40e4381e81a
Autor:
Yingxin Lin, Tung-Yu Wu, Xi Chen, Sheng Wan, Brian Chao, Jingxue Xin, Jean Y.H. Yang, Wing H. Wong, Y. X. Rachel Wang
Publikováno v:
bioRxiv
Single-cell technologies offer unprecedented opportunities to dissect gene regulatory mecha-nisms in context-specific ways. Although there are computational methods for extracting gene regulatory relationships from scRNA-seq and scATAC-seq data, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cd79a3871a4a77f16fb82a9f0b4435
https://doi.org/10.1101/2023.05.18.541381
https://doi.org/10.1101/2023.05.18.541381
Autor:
Alexander M. Menzies, Georgina V. Long, Jean Y.H. Yang, Richard A. Scolyer, Helen Rizos, Richard F. Kefford, Rajat Rai, Jennifer L. McQuade, Douglas B. Johnson, Graham Mann, Yibing Yan, Matthew Wongchenko, Camelia Quek, John J. Park, Matteo S. Carlino, Jeff Holst, James S. Wilmott, Kevin Y.X. Wang, Inês Pires da Silva
Supplementary Tables 1-2, and Figures 1-5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179d0524777c3af190760d3efd016f3e
https://doi.org/10.1158/1078-0432.22467960.v1
https://doi.org/10.1158/1078-0432.22467960.v1
Autor:
Helen Rizos, Georgina V. Long, Richard A. Scolyer, Richard F. Kefford, Shila Ghazanfar, Jean Y.H. Yang, Edmond J. Breen, Matteo S. Carlino, Alexander Guminski, Alexander M. Menzies, Tuba N. Gide, Jenny H. Lee, Su Y. Lim
Purpose:Combination PD-1 and CTLA-4 inhibitor therapy has dramatically improved the survival of patients with advanced melanoma but is also associated with significant immune-related toxicities. This study sought to identify circulating cytokine biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d3eaa51d55080f73302011c477ca9d
https://doi.org/10.1158/1078-0432.c.6527907.v1
https://doi.org/10.1158/1078-0432.c.6527907.v1
Autor:
Helen Rizos, Georgina V. Long, Richard A. Scolyer, Richard F. Kefford, Shila Ghazanfar, Jean Y.H. Yang, Edmond J. Breen, Matteo S. Carlino, Alexander Guminski, Alexander M. Menzies, Tuba N. Gide, Jenny H. Lee, Su Y. Lim
Supplementary Table 1: Number of plasma samples included in the study Supplementary Table 2: Association of toxicity with treatment response Supplementary Table 3: Differentially expressed cytokines in patients with severe irAEs compared to those wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfba89671918e2ef2f79a45ba700c99a
https://doi.org/10.1158/1078-0432.22471476.v1
https://doi.org/10.1158/1078-0432.22471476.v1
Autor:
Alexander M. Menzies, Georgina V. Long, Jean Y.H. Yang, Richard A. Scolyer, Helen Rizos, Richard F. Kefford, Rajat Rai, Jennifer L. McQuade, Douglas B. Johnson, Graham Mann, Yibing Yan, Matthew Wongchenko, Camelia Quek, John J. Park, Matteo S. Carlino, Jeff Holst, James S. Wilmott, Kevin Y.X. Wang, Inês Pires da Silva
Purpose:BRAF V600E and V600K melanomas have distinct clinicopathologic features, and V600K appear to be less responsive to BRAFi±MEKi. We investigated mechanisms for this and explored whether genotype affects response to immunotherapy.Experimental D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91753d57261be99f1f1364e25b7b07c1
https://doi.org/10.1158/1078-0432.c.6526800
https://doi.org/10.1158/1078-0432.c.6526800
The recent emergence of multi-sample multi-condition single-cell multi-cohort studies allow researchers to investigate different cell states. The effective integration of multiple large-cohort studies promises biological insights into cells under dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba093868d5ce44f22173bbfc4b2d282a
https://doi.org/10.1101/2022.12.08.519588
https://doi.org/10.1101/2022.12.08.519588