Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Jean Y. J. Wang"'
Autor:
Yuki Ishii, May Keu Nhiayi, Edison Tse, Jonathan Cheng, Michele Massimino, Donald L Durden, Paolo Vigneri, Jean Y J Wang
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140585 (2015)
Knockout serum replacement (KOSR) is a nutrient supplement commonly used to replace serum for culturing stem cells. We show here that KOSR has pro-survival activity in chronic myelogenous leukemia (CML) cells transformed by the BCR-ABL oncogene. Inhi
Externí odkaz:
https://doaj.org/article/ba8731ff68884ffd877f7d505ded2c60
Autor:
Jorge E S de Souza, André F Fonseca, Renan Valieris, Dirce M Carraro, Jean Y J Wang, Richard D Kolodner, Sandro J de Souza
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94147 (2014)
A new method, which allows for the identification and prioritization of predicted cancer genes for future analysis, is presented. This method generates a gene-specific score called the "S-Score" by incorporating data from different types of analysis
Externí odkaz:
https://doaj.org/article/e376cc8a1dcb426691e88793616e1357
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77495 (2013)
TNF-Related Apoptosis Inducing Ligand (TRAIL) binds to and activates death receptors to stimulate caspase-8 and apoptosis with higher efficiency in cancer than normal cells but the development of apoptosis resistance has limited its clinical efficacy
Externí odkaz:
https://doaj.org/article/ba97d69dec7f4320ab4e7a692978ad9d
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination
Autor:
Elaine Guo, Christopher D. Putnam, Timothy C. Gahman, Yuki Ishii, James L. Mueller, Jean Y. J. Wang, Richard D. Kolodner, Anjana Srivatsan
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 32
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 32
Significance Analysis of synthetic lethal relationships identified in Saccharomyces cerevisiae was used to identify candidate therapeutic targets for cancers with BRCA1 or BRCA2 defects. Inhibition of one of these targets, flap endonuclease 1 (FEN1),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24f3e7d46beaa59510638a581fb0da0
https://pubmed.ncbi.nlm.nih.gov/32817488
https://pubmed.ncbi.nlm.nih.gov/32817488
Publikováno v:
Nature structural & molecular biology
Nature structural & molecular biology, vol 25, iss 11
Nature structural & molecular biology, vol 25, iss 11
Transcriptome analysis reveals a strong positive correlation between human Schlafen family member 11 (SLFN11) expression and the sensitivity of tumor cells to DNA-damaging agents (DDAs). Here, we show that SLFN11 preferentially inhibits translation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417a9fb1ba49bf17f4c31af94bd0c61e
http://europepmc.org/articles/PMC6579113
http://europepmc.org/articles/PMC6579113
Publikováno v:
Molecular biology of the cell, vol 29, iss 18
Molecular Biology of the Cell
Molecular Biology of the Cell
Ionizing radiation (IR) not only activates DNA damage response (DDR) in irradiated cells but also induces bystander effects (BE) in cells not directly targeted by radiation. How DDR pathways activated in irradiated cells stimulate BE is not well unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80da9c795cf200d7b4a71f53ab9a1af4
https://doi.org/10.1091/mbc.e18-02-0130
https://doi.org/10.1091/mbc.e18-02-0130
Autor:
Samantha G Zeitlin, Brian R Chapados, Norman M Baker, Caroline Tai, Geir Slupphaug, Jean Y J Wang
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17151 (2011)
Uracil is removed from DNA by the conserved enzyme uracil DNA N-glycosylase (UNG). Previously, we observed that inhibiting UNG in Xenopus egg extracts blocked assembly of CENP-A, a histone H3 variant. CENP-A is an essential protein in all species, si
Externí odkaz:
https://doaj.org/article/daa6d77585eb4b38b51f181627e19706
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17020 (2011)
The constitutively activated BCR-ABL tyrosine kinase of chronic myeloid leukemia (CML) is localized exclusively to the cytoplasm despite the three nuclear localization signals (NLS) in the ABL portion of this fusion protein. The NLS function of BCR-A
Externí odkaz:
https://doaj.org/article/ebd8650fe9594aa1acb660840c93a964
Publikováno v:
PLoS ONE, Vol 1, p e82 (2006)
The human retinoblastoma susceptibility gene encodes a nuclear phosphoprotein RB, which is a negative regulator of cell proliferation. The growth suppression function of RB requires an evolutionarily conserved A/B domain that contains two distinct pe
Externí odkaz:
https://doaj.org/article/d45d446371cf40569ed9e049f52b31ed
Autor:
Sarah H. Lisanby, Simon W. Davis, Lysianne Beynel, Alexandra Brito, D. Lakhlani, Angel V. Peterchev, Bruce Luber, Jean Y. J. Wang, Hannah Palmer, Courtney A. Crowell, Lawrence G. Appelbaum, Susan A. Hilbig, Roberto Cabeza, Lifu Deng
Neuroimaging evidence suggests that the aging brain relies on a more distributed set of cortical regions than younger adults in order to maintain successful levels of performance during demanding cognitive tasks. However, it remains unclear how task
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754a785b92a5f3adf3bf0b0eca85c544
