Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jean Vianney Haure-Mirande"'
Autor:
Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby, Michelle E. Ehrlich
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-26 (2024)
Abstract Introduction Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. Detection of ac
Externí odkaz:
https://doaj.org/article/b2af945c340e484f850a0185183190e3
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-15 (2022)
Abstract TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is expressed in numerous cell types, including peripheral blood mono
Externí odkaz:
https://doaj.org/article/fa4ba4af768d47818ebaa16fe43f4912
Autor:
Noam D. Beckmann, Wei-Jye Lin, Minghui Wang, Ariella T. Cohain, Alexander W. Charney, Pei Wang, Weiping Ma, Ying-Chih Wang, Cheng Jiang, Mickael Audrain, Phillip H. Comella, Amanda K. Fakira, Siddharth P. Hariharan, Gillian M. Belbin, Kiran Girdhar, Allan I. Levey, Nicholas T. Seyfried, Eric B. Dammer, Duc Duong, James J. Lah, Jean-Vianney Haure-Mirande, Ben Shackleton, Tomas Fanutza, Robert Blitzer, Eimear Kenny, Jun Zhu, Vahram Haroutunian, Pavel Katsel, Sam Gandy, Zhidong Tu, Michelle E. Ehrlich, Bin Zhang, Stephen R. Salton, Eric E. Schadt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, w
Externí odkaz:
https://doaj.org/article/f3a49830ea0b40449d13d63b2ea4d0a8
Autor:
Shouneng Peng, Lu Zeng, Jean-Vianney Haure-Mirande, Minghui Wang, Derek M. Huffman, Vahram Haroutunian, Michelle E. Ehrlich, Bin Zhang, Zhidong Tu
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Aging is a major risk factor for late-onset Alzheimer’s disease (LOAD). How aging contributes to the development of LOAD remains elusive. In this study, we examined multiple large-scale transcriptomic datasets from both normal aging and LOAD brains
Externí odkaz:
https://doaj.org/article/edd42ca4f7c84ac29d263d4073145dca
Autor:
Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom V. Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan I. Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107908- (2020)
Summary: We present a consensus atlas of the human brain transcriptome in Alzheimer’s disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from seven regions as
Externí odkaz:
https://doaj.org/article/c0a8fce1711e4e8caa8aeb71e0b9458a
Autor:
Mesude Bicak, Georgina E. Perez‐Garcia, Jacqueline Buros, Jean‐Vianney Haure‐Mirande, Gissel E. Perez, Alena Otero‐Pagan, Miguel E. Gama‐Sosa, Rita E. DeGasperi, Mary Sano, Fred H. Gage, Carrolee Barlow, Joel Dudley, Benjamin S. Glicksberg, Yanzhuang Wang, Benjamin Readhead, Michelle E. Ehrlich, Gregory A. Elder, Sam Gandy
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::577a5c9ef3ba31ef4a38fa30f7fb6240
https://doi.org/10.1002/alz.062751
https://doi.org/10.1002/alz.062751
Autor:
Emilie L. Castranio, Philip Hasel, Jean‐Vianney Haure‐Mirande, Angie V. Ramirez Jimenez, B. Wade Hamilton, Rachel D. Kim, Charles G. Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A. Liddelow, Michelle E. Ehrlich
Publikováno v:
Alzheimer's & Dementia.
The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4818097de544fc665949b91f0b448a3
https://doi.org/10.1002/alz.12821
https://doi.org/10.1002/alz.12821
Autor:
Jennifer K. Griffin, Jean-Vianney Haure-Mirande, Peter St George-Hyslop, Michelle E. Ehrlich, Paul E. Fraser, Bin Zhang, Sam Gandy, Justyna Mleczko, Minghui Wang, Mickael Audrain
Publikováno v:
Alzheimer's & Dementia
Introduction Microglial TYROBP (DAP12) is a network hub and driver in sporadic late‐onset Alzheimer's disease (AD). TYROBP is a cytoplasmic adaptor for TREM2 and other receptors, but little is known about its roles and actions in AD. Herein, we dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0803f774d30eaa3d4e210d62668532ac
http://europepmc.org/articles/PMC7938663
http://europepmc.org/articles/PMC7938663
Autor:
Jean-Vianney Haure-Mirande, Ben Readhead, Joel T. Dudley, Soong H. Kim, Michelle E. Ehrlich, Mickael Audrain, Diego Mastroeni, Tomas Fanutza, Sam Gandy, Robert D. Blitzer
Publikováno v:
Acta Neuropathol
MicroRNAs are recognized as important regulators of many facets of physiological brain function while also being implicated in the pathogenesis of several neurological disorders. Dysregulation of miR155 is widely reported across a variety of neurodeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ecdb5c12f03753598f25cb3255691b
https://doi.org/10.1007/s00401-020-02185-z
https://doi.org/10.1007/s00401-020-02185-z
Autor:
Georgina Perez-Garcia, Mesude Bicak, Jacqueline Buros, Jean-Vianney Haure-Mirande, Gissel M. Perez, Alena Otero-Pagan, Miguel A. Gama Sosa, Rita De Gasperi, Mary Sano, Fred H. Gage, Carrolee Barlow, Joel T. Dudley, Benjamin S. Glicksberg, Yanzhuang Wang, Benjamin Readhead, Michelle E. Ehrlich, Gregory A. Elder, Sam Gandy
Modulation of physical activity represents an important intervention that may delay, slow, or prevent mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD). One mechanism proposed to underlie the beneficial effect of physical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecf9b941bcbebe4bcbe8c225bdbd101
https://doi.org/10.1101/2022.01.31.477906
https://doi.org/10.1101/2022.01.31.477906
