Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jean Sevalle"'
Autor:
Lisa-Maria Needham, Masahiro Enomoto, Yalun Zhang, Arturas Bruzas, Roger B. Dodd, Kanayo Satoh, David Klenerman, Fusheng Chen, Paul E. Fraser, Jean Sevalle, Steven F. Lee, Seema Qamar, Peter St George-Hyslop, Jochen Walter, David H. Allendorf, James Henderson, Jennifer K. Griffin, Guy C. Brown, Miguel Angel Burguillos, Suman De, Ye Zhou, Anna Vilalta, Mar Puigdellívol, Patrick Flagmeier
Missense mutations (e.g. R47H) of the microglial receptor TREM2 increase risk of Alzheimer’s disease (AD), and the soluble ectodomain of wild-type TREM2 (sTREM2) appears to protect in vivo, but the underlying mechanisms are unclear. We show that A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68e4a017607189fee2054e1aa314424
https://doi.org/10.1101/2020.12.03.409995
https://doi.org/10.1101/2020.12.03.409995
Autor:
F-F Chen, Roger B. Dodd, Gerold Schmitt-Ulms, PH St George-Hyslop, Yi Li, Seema Qamar, Christopher Bohm, Jean Sevalle, Paul E. Fraser
Publikováno v:
Molecular and Cellular Neurosciences
Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid β-peptide (Aβ)
Autor:
Marie-Agnès Lacour, Jean Martinez, Fabien Rodier, Vincent Lisowski, Youness Touati-Jallabe, Marine Peuchmaur, Frédéric Checler, Jean-François Hernandez, Jean Sevalle
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:1018-1029
The 3-alkoxy-7-amino-4-chloro-isocoumarins JLK-6 and JLK-2 have been shown to markedly reduce the production of Amyloid β-peptide (Aβ) by Amyloid-β Precursor Protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with
Autor:
Ephrat Levy-Lahad, Clement A. Gautier, Nathalie Leroudier, Eric Duplan, Olga Corti, Frédéric Checler, Cristine Alves da Costa, Julien Viotti, Charlotte Bauer, Paul Renbaum, Thomas Goiran, Jean Sevalle
Publikováno v:
Journal of Molecular Cell Biology. 5:132-142
We previously established that besides its canonical function as E3-ubiquitin ligase, parkin also behaves as a transcriptional repressor of p53. Here we show that parkin differently modulates presenilin-1 and presenilin-2 expression and functions at
Autor:
Bénédicte Oulès, Patrizia Paterlini-Bréchot, Dolores Del Prete, Mounia Chami, Inger Lauritzen, Barbara Greco, Xuexin Zhang, Frédéric Checler, Sébastien Moreno, Mohamed Trebak, Jean Sevalle, Fabio Benfenati
Publikováno v:
The Journal of Neuroscience. 32:11820-11834
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca2+) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein (APP), thereby generating amy
Autor:
Raphaëlle Pardossi-Piquard, Jean Sevalle, Brice Flammang, Delphine Debayle, Frédéric Checler, Anne-Sophie Dabert-Gay, Inger Lauritzen, Aurelie Thevenet
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2012, 30 (1), pp.145-53. ⟨10.3233/JAD-2012-112186⟩
Journal of Alzheimer's Disease, IOS Press, 2012, 30 (1), pp.145-53. ⟨10.3233/JAD-2012-112186⟩
International audience; One of the major pathological hallmarks of brains affected with Alzheimer's disease (AD) is the senile plaque, an extracellular deposit mainly composed of a set of highly insoluble peptides of various lengths (39-43 amino acid
Autor:
Raphaëlle Pardossi-Piquard, Tong Li, Seung Pil Yang, Gerold Schmitt-Ulms, Yongjun Gu, Frédéric Checler, Peter St George-Hyslop, Paul E. Fraser, Fusheng Chen, Jean Sevalle, Philip C. Wong, Christopher Bohm, Soshi Kanemoto
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (24), pp.16298-307. ⟨10.1074/jbc.M109.000067⟩
The Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (24), pp.16298-307. ⟨10.1074/jbc.M109.000067⟩
The Journal of Biological Chemistry
International audience; Complexes involved in the gamma/epsilon-secretase-regulated intramembranous proteolysis of substrates such as the amyloid-beta precursor protein are composed primarily of presenilin (PS1 or PS2), nicastrin, anterior pharynx de
Autor:
Frédéric Checler, Peter St George-Hyslop, Nadège Girardot, Raphaëlle Pardossi-Piquard, Jean Sevalle, Bruno Vincent, Toshitaka Kawarai, Claire Sunyach, Cristine Alves da Costa
Publikováno v:
Current Alzheimer Research. 4:423-426
Amyloid beta-peptide (Abeta), which plays a central role in Alzheimer Disease, is generated by presenilin-dependent and presenilin-independent gamma-secretase cleavages of beta-amyloid precursor protein (betaAPP). We report that the presenilins (PS1
Presenilin-Dependent -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease
Autor:
Bruno Vincent, Nicole Boyer, Raphaëlle Pardossi-Piquard, Nadège Girardot, Cristine Alves da Costa, Peter St George-Hyslop, T. Kawarai, Claire Sunyach, Frédéric Checler, Jean Sevalle
Publikováno v:
Journal of Neuroscience. 26:6377-6385
Presenilins (PSs) are part of the gamma-secretase complex that produces the amyloid beta-peptide (Abeta) from its precursor [beta-amyloid precursor protein (betaAPP)]. Mutations in PS that cause familial Alzheimer's disease (FAD) increase Abeta produ
Autor:
Emilie Giaime, Cristine Alves da Costa, Hiroyoshi Ariga, Julien Viotti, Ling Qi, Jean Sevalle, Frédéric Checler, Alexis Brice, Eric Duplan, Olga Corti
Parkin and DJ-1 are two multi-functional proteins linked to autosomal recessive early-onset Parkinson's disease (PD) that have been shown to functionally interact by as-yet-unknown mechanisms. We have delineated the mechanisms by which parkin control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08176396d5355ee8bda6764b1e75fe43
https://europepmc.org/articles/PMC6518232/
https://europepmc.org/articles/PMC6518232/