Targeting the PI3K/Akt/mTOR pathway in estrogen-receptor positive HER2 negative advanced breast cancer

Autor: Pauline du Rusquec, Cyriac Blonz, Jean Sebastien Frenel, Mario Campone

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 12 (2020)

Recently many therapeutic classes have emerged in advanced hormone receptor-positive breast cancer, which is the leading cause of cancer death in women. In absence of visceral crisis, treatment relies on endocrine therapy combined with cyclin depende

Externí odkaz: https://doaj.org/article/8b1b051acf4145d58d96075668e7bba1

Functional pre-therapeutic evaluation by genome editing of variants of uncertain significance of essential tumor suppressor genes

Autor: Amandine Billaud, Louise-Marie Chevalier, Paule Augereau, Jean-Sebastien Frenel, Christophe Passot, Mario Campone, Alain Morel

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)

Abstract Background Targeted therapies in oncology are promising but variants of uncertain significance (VUS) limit their use for clinical management and necessitate functional testing in vitro. Using BRCA1 and BRCA2 variants, which have consequences

Externí odkaz: https://doaj.org/article/79c1e3cddf6545f2a4bd74aab526e620

Characteristics and outcome of breast cancer-related microangiopathic haemolytic anaemia: a multicentre study

Autor: Marion Alhenc-Gelas, Luc Cabel, Frederique Berger, Suzette Delaloge, Jean-Sebastien Frenel, Christelle Levy, Nelly Firmin, Sylvain Ladoire, Isabelle Desmoulins, Pierre-Etienne Heudel, Florence Dalenc, Delphine Loirat, Coraline Dubot, Perrine Vuagnat, Elise Deluche, Meriem Mokdad-Adi, Anne Patsouris, Josselin Annic, Lounes Djerroudi, Marion Lavigne, Jean-Yves Pierga, Paul Coppo, Francois-Clement Bidard

Publikováno v: Breast Cancer Research, Vol 23, Iss 1, Pp 1-10 (2021)

Abstract Background Cancer-related microangiopathic haemolytic anaemia (MAHA) is a rare but life-threatening paraneoplastic syndrome. Only single cases or small series have been reported to date. We set up a retrospective multicentre study focusing o

Externí odkaz: https://doaj.org/article/f7239abd3511401b9773a7aef4c9d1ce

Response to first line platinum-based chemotherapy in mismatch repair deficient (MMRd)/ microsatellite instability high (MSI-high) endometrial carcinoma

Autor: Emeline, Colomba, Jérôme, Alexandre, Gwénaël, Le Teuff, Catherine, Genestie, Dahna, Coupez, Isabelle Ray, Coquard, Pierre Emmanuel, Brachet, Sixtine, de Percin, Christophe, Sajous, Michel, Fabbro, Nicolas, Delanoy, Florence, Joly, Jean Sebastien, Frenel, Patricia, Pautier, Alexandra, Leary

Publikováno v: Gynecologic Oncology. 169:78-84

Around 15% of metastatic endometrial carcinoma (EC) are MMRd/MSI-H improving response to immune checkpoint inhibitors (ICI). So far, few data existed considering the chemotherapy (CT) sensitivity in MMRd/MSI-H EC, especially response to first-line pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e1dcbaa6573f8d88a27ec68f4eef1c
https://doi.org/10.1016/j.ygyno.2022.11.029

Corticosteroids use and neurocognitive functioning in patients with recurrent glioblastoma

Autor: Ivan Caramanna, Julie M de Kort, Alba A Brandes, Walter Taal, Michael Platten, Ahmed Idbaih, Jean Sebastien Frenel, Wolfgang Wick, Chandrakanth Jayachandran Preetha, Martin Bendszus, Philipp Vollmuth, Jaap C Reijneveld, Martin Klein

Publikováno v: Neuro-Oncology Practice, 9(4), 310-316. Oxford University Press
Caramanna, I, de Kort, J M, Brandes, A A, Taal, W, Platten, M, Idbaih, A, Frenel, J S, Wick, W, Preetha, C J, Bendszus, M, Vollmuth, P, Reijneveld, J C & Klein, M 2022, ' Corticosteroids use and neurocognitive functioning in patients with recurrent glioblastoma : Evidence from European Organization for Research and Treatment of Cancer (EORTC) trial 26101 ', Neuro-Oncology Practice, vol. 9, no. 4, pp. 310-316 . https://doi.org/10.1093/nop/npac022

Background In patients with recurrent glioblastoma, corticosteroids are frequently used to mitigate intracranial pressure and to improve patient neurological functioning. To date, in these patients, no systematic studies have been performed to assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2c28b8c5f8c59785ef305e12fec0bb
http://www.scopus.com/inward/record.url?scp=85135757142&partnerID=8YFLogxK