Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Jean S. Marshall"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Fibrosis is a destructive, end-stage disease process. In the skin, it is associated with systemic sclerosis and scarring with considerable health burden. Ketotifen is a clinical antihistamine and mast cell stabilizer. Studies have demonstrat
Externí odkaz:
https://doaj.org/article/68dbb5d70bf14acc871b441430385461
Autor:
Anikó E. Malik, Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Jean S. Marshall, Thomas B. Issekutz
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveAntigen-presenting dendritic cells (DCs) and monocytes play an essential role in rheumatoid arthritis (RA) pathogenesis, however, their tolerogenic potential remains unclear. Herein, the tolerogenic profiles of DCs are characterized in treat
Externí odkaz:
https://doaj.org/article/ada887f28e424002807018d3e254353f
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1238 (2024)
Abnormal skin healing resulting in chronic wounds or hypertrophic scarring remains a major healthcare burden. Here, the antifibrotic angiotensin II type 2 receptor (AT2R) signaling pathway was modulated to determine its impact on cutaneous wound heal
Externí odkaz:
https://doaj.org/article/d9e7ad55547e4b7b8e198178306b1f19
Autor:
Joel Bierer, Roger Stanzel, Mark Henderson, Suvro Sett, John Sapp, Pantelis Andreou, Jean S. Marshall, David Horne
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Cardiopulmonary bypass (CPB) is associated with systemic inflammation, featuring increased levels of circulating pro-inflammatory cytokines. Intra-operative ultrafiltration extracts fluid and inflammatory factors potentially dampe
Externí odkaz:
https://doaj.org/article/72e4bdc396a44a97a0de612399858024
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionChlamydia trachomatis (C. trachomatis) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor infertility. We hypothesized that mast cells,
Externí odkaz:
https://doaj.org/article/f01588e5dca842319608163330d3eeb4
Autor:
Julia M. Harrison, PhD, BScH, Edwin K. Leong, MSc, BScH, Jean S. Marshall, PhD, BScH, Michael Bezuhly, MD, MSc, BScH
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 11, Iss 5S, Pp 54-55 (2023)
Externí odkaz:
https://doaj.org/article/ea038efedad943e4ad8b073cfa61f269
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R is expressed by multiple immune cells, yet little is known about the im
Externí odkaz:
https://doaj.org/article/a0ea238050584e758838b44b7727969a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mast cells are specialized, tissue resident, immune effector cells able to respond to a wide range of stimuli. MCs are involved in the regulation of a variety of physiological functions, including vasodilation, angiogenesis and pathogen elimination.
Externí odkaz:
https://doaj.org/article/f5ef469d0ae24f7aa79ad0de111f7151
Autor:
Barakat Alrashdi, Bassel Dawod, Andrea Schampel, Sabine Tacke, Stefanie Kuerten, Jean S. Marshall, Patrice D. Côté
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background In multiple sclerosis (MS) and in the experimental autoimmune encephalomyelitis (EAE) model of MS, the Nav1.6 voltage-gated sodium (Nav) channel isoform has been implicated as a primary contributor to axonal degeneration. Followin
Externí odkaz:
https://doaj.org/article/efe52f70917a403088eea9e0e338ee35
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mast cells are well known to be activated via cross-linking of immunoglobulins bound to surface receptors. They are also recognized as key initiators and regulators of both innate and adaptive immune responses against pathogens, especially in the ski
Externí odkaz:
https://doaj.org/article/b27392e6d18b4fd7a035445f1e808c4c