Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jean Roch Meunier"'
Autor:
Jens M. Kelm, George R. Jackson, Marcel Leist, James F. Rathman, Stephanie Ringeissen, Ann Detroyer, Jean Roch Meunier, Brett A. Lidbury, Nina Hasiwa, Chihae Yang, Gina Stolper, Patrick Hayden
Publikováno v:
ALTEX; Vol 29
Several alternative methods to replace animal experiments have been accepted by legal bodies. An even larger number of tests are under development or already in use for non-regulatory applications or for the generation of information stored in propri
Autor:
Hemanta Kumar Kar, Rajesh S. Gokhale, Rajni Rani, Pankaj Sharma, Vivek T. Natarajan, Krishnamurthy Natarajan, Avinash Kumar, Laurent Marrot, Jean-Roch Meunier, Archana Singh
Publikováno v:
Journal of Investigative Dermatology. 130(12):2781-2789
Oxidative stress is widely believed to be a contributing factor in vitiligo pathogenesis. To explore mechanisms by which epidermis responds to mounting oxidative stress, we investigated the involvement of phase II detoxification genes in vitiligo. Ph
Autor:
Emilie Planel, Jean-Roch Meunier, Laurent Marrot, Jean-Philippe Belaïdi, Anne-Claire Ginestet, Christophe Jones
Publikováno v:
Photochemical & Photobiological Sciences. 9:448-458
Epidermal keratinocytes are critical targets for UV-induced genotoxicity as their transformation by sunlight overexposure can lead to skin cancer such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Therefore, assessment of photoprot
Autor:
Marie-Hélène Grandidier, Sophie Loisel-Joubert, Anne-Marie Minondo, Carolle Amsellem, José Cotovio, Damien Lelièvre, Christophe Capallere, Jacques Leclaire, Estelle Tinois-Tessonneaud, Béatrice Bertino, Anne De Brugerolle de Fraissinette, Saber Maloug, Christelle Bremond, Jean-Marc Ovigne, Nathalie Alépée, Jean-Roch Meunier, Aline Van Der Lee
Publikováno v:
Toxicology in Vitro. 24:523-537
The 7th amendment of the EU Cosmetics Directive led to the ban of eye irritation testing for cosmetic ingredients in animals, effective from March 11th 2009. Over the last 20 years, many efforts have been made to find reliable and relevant alternativ
Autor:
Jean-Roch Meunier, Laurent Marrot
Publikováno v:
Hit and Lead Profiling
Publikováno v:
Photochemistry and Photobiology. 75:437-447
During the past several years, phototoxicity has been studied at the molecular level, and these studies have provided new insights in the field of DNA lesion characterization, DNA repair and cell response to ultraviolet (UV)-induced stress. The devel
Publikováno v:
Toxicology in Vitro. 20:1040-1050
Photoreactive chemicals can induce dermatological reactions when present in the skin exposed to sunlight. Thus, new chemicals absorbing above 290 nm should have their potential phototoxicity tested. In order to screen a large number of molecules with
Autor:
Jo Oliver, Jean-Roch Meunier, Takumi Awogi, Azeddine Elhajouji, Marie-Claude Ouldelhkim, Nicole Bichet, Veronique Thybaud, Giocondo Lorenzon, Daniel Marzin, Elisabeth Lorge
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 607:125-152
Autor:
Emilie Dourille, Nicole Flamand, Jean-Philippe Belaïdi, Linda Bourouf, Laurent Marrot, Jean-Roch Meunier, Michèle Feltes
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 606:39-51
Today reconstructed skin models that simulate human skin, such as Episkin, are widely used for safety or efficacy pre-screening. Moreover, they are of growing interest for regulatory purposes in the framework of alternatives to animal testing. In ord
Autor:
C Chaubo, Philippe Perez, Catherine Agapakis-Causse, Jean-Philippe Belaïdi, Jean Roch Meunier, Laurent Marrot
Publikováno v:
Toxicology in Vitro. 15:131-142
Today's lifestyle is often associated with frequent exposure to sunlight, but some xenobiotics used in drugs, cosmetics or food chemicals can produce adverse biological effects when irradiated. In particular, they can increase the risk of photogenoto