Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution

Autor: Jean R. Fakhoury, Fazle Hussain, O'Hara Haley, Jeffrey Schmulen, Paolo Decuzzi, Padraig Moloney, Anne L. van de Ven, Giulia Adriani, Seok Hyun Yun, Mauro Ferrari, Xuewu Liu, Pilhan Kim

Publikováno v: Journal of Controlled Release. 158:148-155

Nanoparticles for cancer therapy and imaging are designed to accumulate in the diseased tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their size to about 100 nm. Here, using intravital microscopy and elemental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f39d70bb4f8388e377a4953f67ac148
https://doi.org/10.1016/j.jconrel.2011.10.021

Cellular Association and Assembly of a Multistage Delivery System

Autor: Xue W. Liu, James A. Bankson, Douglas Webb, Merlyn X. Pulikkathara, Ana Maria Zaske, Jodie L. Conyers, Rita E. Serda, Jean R. Fakhoury, Ciro Chiappini, Aaron Mack, Biana Godin, Mauro Ferrari

Publikováno v: Small. 6:1329-1340

The realization that blood-borne delivery systems must overcome a multiplicity of biological barriers has led to the fabrication of a multi-stage delivery system (MDS) designed to temporally release successive stages of particles or agents to conquer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65b3a2ac8d2635d32437d45e8ba1a9f0
https://doi.org/10.1002/smll.201000126

Biodegradable porous silicon barcode nanowires with defined geometry

Autor: Ciro Chiappini, Jean R. Fakhoury, Xuewu Liu, Mauro Ferrari

Publikováno v: Advanced functional materials. 20(14)

were reported.pNWs couple the nanowire 1-D structure to the unique character-istics of porous silicon, showing promise for the realization offlexible, biodegradable electronic and photonic biomedical deviceswith high sensitivity to the surrounding e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f576c022e8acc6454836d93794442893
https://pubmed.ncbi.nlm.nih.gov/21057669

Nanostructures: Biodegradable Porous Silicon Barcode Nanowires with Defined Geometry (Adv. Funct. Mater. 14/2010)

Autor: Jean R. Fakhoury, Xuewu Liu, Ciro Chiappini, Mauro Ferrari

Publikováno v: Advanced Functional Materials. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab32390489111b1d5b913ad60c27e6cf
https://doi.org/10.1002/adfm.201090058

Sustained small interfering RNA delivery by mesoporous silicon particles

Autor: Anil K. Sood, Biana Godin, Takemi Tanaka, Mian M.K. Shahzad, Lingegowda S. Mangala, Koji Matsuo, Gabriel Lopez-Berestein, Jianhua Gu, Jean R. Fakhoury, Pablo E. Vivas-Mejia, Hee Dong Han, René Nieves-Alicea, Aman P. Mann, Edna M. Mora, Rohan Bhavane, Rebecca L. Stone, Alpa M. Nick, Ciro Chiappini, Xuewu Liu, Chunhua Lu, Mauro Ferrari

Publikováno v: Tanaka, T, Mangala, L S, Vivas-Mejia, P E, Nieves-Alicea, R, Mann, A P, Mora, E, Han, H-D, Shahzad, M M K, Liu, X, Bhavane, R, Gu, J, Fakhoury, J R, Chiappini, C, Lu, C, Matsuo, K, Godin, B, Stone, R L, Nick, A M, Lopez-Berestein, G, Sood, A K & Ferrari, M 2010, ' Sustained small interfering RNA delivery by mesoporous silicon particles ', Cancer Research, vol. 70, no. 9, pp. 3687-3696 . https://doi.org/10.1158/0008-5472.CAN-09-3931

RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcc26b5e5f9aeccb745579a8312e35e
https://pubmed.ncbi.nlm.nih.gov/20614560