Zobrazeno 1 - 10
of 465
pro vyhledávání: '"Jean Pierre Timmermans"'
Autor:
Vincent Van Rompaey, Alex Liesenborghs, Karel Goyvaerts, Daan De Herdt, Dorien Verdoodt, Marc Lammers, Paul Van de Heyning, Olivier Vanderveken, Krystyna Szewczy, Sofie Thys, Isabel Pintelon, Jean Pierre Timmermans, Jordi Llorens, Peter De Deyn, Debby Van Dam
Publikováno v:
B-ENT, Vol 17, Iss 4, Pp 223-233 (2021)
Externí odkaz:
https://doaj.org/article/0b569f478cd94cdcb144de23e2ace08f
Autor:
Robin Colenbier, Lenny Coppens, Tine Logghe, Eke van Zwol, Jean-Pierre Timmermans, Johannes Bogers
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102968- (2024)
Summary: The chorioallantoic membrane (CAM) model is an increasingly attractive model for the study of human tumors. However, concise techniques for the use of pancreatic ductal adenocarcinoma BxPC-3 xenografts in CAM assays are not yet available. He
Externí odkaz:
https://doaj.org/article/31cb0a348b124ef19c2c082a9871435d
Autor:
Peter Verstraelen, Samuel Van Remoortel, Nouchin De Loose, Rosanne Verboven, Gerardo Garcia-Diaz Barriga, Anne Christmann, Manuela Gries, Shingo Bessho, Jing Li, Carmen Guerra, Çagla Tükel, Sales Ibiza Martinez, Karl-Herbert Schäfer, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 89-104 (2024)
Background & Aims: Mounting evidence suggests the gastrointestinal microbiome is a determinant of peripheral immunity and central neurodegeneration, but the local disease mechanisms remain unknown. Given its potential relevance for early diagnosis an
Externí odkaz:
https://doaj.org/article/9e6f75de89f84982823a97136cab22fe
Autor:
Baharak Hosseinkhani, Gayel Duran, Cindy Hoeks, Doryssa Hermans, Melissa Schepers, Paulien Baeten, Joren Poelmans, Britt Coenen, Kübra Bekar, Isabel Pintelon, Jean-Pierre Timmermans, Tim Vanmierlo, Luc Michiels, Niels Hellings, Bieke Broux
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of demyelination and neurodegeneration in multiple sclerosis (MS). Recently, extracellular vesicles
Externí odkaz:
https://doaj.org/article/f4acca77f25e4bbea5bea993dc45f437
Autor:
Samuel Van Remoortel, Lana Lambeets, Benedicte De Winter, Xinzhong Dong, Juan Pablo Rodriguez Ruiz, Samir Kumar-Singh, Sales Ibiza Martinez, Jean-Pierre Timmermans
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101391- (2024)
Background & Aims: Mast cells (MCs) are typically found at mucosal surfaces, where their immunoglobulin E (IgE)-dependent activation plays a central role in allergic diseases. Over the past years, signaling through Mas-related G protein-coupled recep
Externí odkaz:
https://doaj.org/article/4c775f20b9054792843727e7ba09c445
Autor:
Dorien Mabille, Laura Dirkx, Sofie Thys, Marjorie Vermeersch, Daniel Montenye, Matthias Govaerts, Sarah Hendrickx, Peter Takac, Johan Van Weyenbergh, Isabel Pintelon, Peter Delputte, Louis Maes, David Pérez-Morga, Jean-Pierre Timmermans, Guy Caljon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
A number of human African trypanosomiasis, or sleeping sickness, patients suffer from respiratory symptoms commonly attributed to cardiac insufficiency. Here, the authors characterise the role of pulmonary Trypanosoma brucei in respiratory infection.
Externí odkaz:
https://doaj.org/article/e94ea4949fe04471983657287813b459
Autor:
Debby Van Dam, Femke Valkenburg, Kristof Van Kolen, Isabel Pintelon, Jean-Pierre Timmermans, Peter Paul De Deyn
Publikováno v:
Life, Vol 13, Iss 10, p 2088 (2023)
Background: The Tau58/2 and Tau58/4 mouse lines expressing 0N4R tau with a P301S mutation mimic aspects of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). In a side-by-side comparison, we report the age-dependent developme
Externí odkaz:
https://doaj.org/article/6c1945a425ec48379ee799912401d6bb
Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies
Autor:
Alessandro Toscano, Jessy Elst, Athina L. Van Gasse, Michiel Beyens, Marie-Line van der Poorten, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Samuel Van Remoortel, Jean-Pierre Timmermans, Didier G. Ebo, Vito Sabato
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
BackgroundOccupancy of MRGPRX2 heralds a new era in our understandings of immediate drug hypersensitivity reactions (IDHRs), but a constitutive expression of this receptor by basophils is debated.ObjectiveTo explore the expression and functionality o
Externí odkaz:
https://doaj.org/article/3574f0d95e434b6f8c78efed4a249e82
Autor:
Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon, Gudrun A. Rappold, Markus Britschgi, Hilal Lashuel, Michael D. Menger, Matthias W. Laschke, Beate Niesler, Karl-Herbert Schäfer
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-23 (2021)
Abstract Background There is increasing evidence that Parkinson’s disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons
Externí odkaz:
https://doaj.org/article/49867127eba049789d3649e16f104dff
TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy
Autor:
Kirsten De Ridder, Hanne Locy, Elisa Piccioni, Miren Ibarra Zuazo, Robin Maximilian Awad, Stefaan Verhulst, Mathias Van Bulck, Yannick De Vlaeminck, Quentin Lecocq, Eva Reijmen, Wout De Mey, Lien De Beck, Thomas Ertveldt, Isabel Pintelon, Jean-Pierre Timmermans, David Escors, Marleen Keyaerts, Karine Breckpot, Cleo Goyvaerts
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. Recent observations indicate a
Externí odkaz:
https://doaj.org/article/8cb0f64de304414d9efd07fa0701e7a3