Výsledky vyhledávání - "Jean Pierre Segain"

Akademický článek

CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia.

Autor: Antoine Roquilly, Laetitia Gautreau, Jean Pierre Segain, Pierre de Coppet, Véronique Sebille, Cédric Jacqueline, Jocelyne Caillon, Gilles Potel, Corinne Lejus, Régis Josien, Karim Asehnoune

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13228 (2010)

Infections are the most frequent cause of complications in trauma patients. Post-traumatic immune suppression (IS) exposes patients to pneumonia (PN). The main pathogen involved in PN is Methicillin Susceptible Staphylococcus aureus (MSSA). Dendritic

Externí odkaz: https://doaj.org/article/f720fb15e5014226b1b801ba18471e51

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Akademický článek

Degraded carrageenan causing colitis in rats induces TNF secretion and ICAM-1 upregulation in monocytes through NF-kappaB activation.

Autor: Claudine Benard, Antonietta Cultrone, Catherine Michel, Carlos Rosales, Jean-Pierre Segain, Marc Lahaye, Jean-Paul Galmiche, Christine Cherbut, Hervé M Blottière

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8666 (2010)

Carrageenan (CGN) is a high molecular weight sulphated polysaccharide derived from red seaweeds. In rodents, its degraded forms (dCGN) can induce intestinal inflammation associated with macrophage recruitment and activation. The aim of this study was

Externí odkaz: https://doaj.org/article/12fcd6dba2b44d23ac3a09c3f8d3abf1

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Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring

Autor: Julien Chevalier, Pierre Antoine Grohard, Jean-Pierre Segain, Gwenola Le Drean, Elena Oleynikova, Philippe Aubert, Michel Neunlist, Marième Ndjim, Catherine Le Berre-Scoul, Hélène Boudin, Hina Rizvi

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (1), pp.770-781. ⟨10.1096/fj.201800079R⟩

International audience; Early-life adversity is a major risk factor for the development of diseases later in life. Maternal protein restriction (MPR) is associated with morbidities in offspring affecting multiple organs, but its impact on the gastroi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e804bde73cfd7aca53dec7207965ff
https://hal.inrae.fr/hal-02624894

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Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs

Autor: Jean-Paul Lallès, Isabelle Nogret, Paul Meurice, David Val-Laillet, Gwenaëlle Randuineau, P. Guilloteau, Michèle Formal, Laurence Le Normand, Jean-Pierre Segain, Sylvie Guerin, Véronique Romé, Charles-Henri Malbert, Nicolas Coquery, Patricia Parnet

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2018, 32 (4), pp.2160-2171. ⟨10.1096/fj.201700547RR⟩
FASEB Journal, 2018, 32 (4), pp.2160-2171. ⟨10.1096/fj.201700547RR⟩

Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neurocognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity and if this would relate to gut function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963b738c8090a3f92dbb5366ee54e4e9
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01771621/document

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The neonatal transfer of intestinal microbiota partially reverse microbiota dysbiosis in rats with intra-uterine growth retardation

Autor: Catherine Michel, HELENE BILLARD, Thomas Moyon, Emmanuel Montassier, Julie Macher, Jean-Pierre Segain

Publikováno v: 5th World Congress on Targeting Microbiota
5th World Congress on Targeting Microbiota, International Society of Microbiota (ISM). INT., Oct 2017, Berlin, Germany
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International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1783da575808deee3c1fdda2944012b3
https://hal.inrae.fr/hal-02735955

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Perinatal supplementation of 4-phenylbutyrate and glutamine attenuates endoplasmic reticulum stress and improves colonic epithelial barrier function in rats born with intrauterine growth restriction

Autor: Pierre de Coppet, Jean-Pierre Segain, Axel Désir-Vigné, Gwenola Le Dréan, Vianney Haure-Mirande, Dominique Darmaun

Publikováno v: Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry, Elsevier, 2018, 55, pp.104-112. ⟨10.1016/j.jnutbio.2017.12.007⟩

International audience; Intrauterine growth restriction (IUGR) can affect the structure and function of the intestinal barrier and increase digestive disease risk in adulthood. Using the rat model of maternal dietary protein restriction (8% vs. 20%),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a69d62c2de6a828dcc18ccb31ab35c
https://pubmed.ncbi.nlm.nih.gov/29413485

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RDP58, a Novel Immunomodulatory Peptide with Anti-Inflammatory Effects. A Pharmacological Study in Trinitrobenzene Sulphonic Acid Colitis and Crohn Disease

Autor: M. Doubremelle, Jean-Pierre Segain, D. Raingeard de la Blétière, C. Toquet, J. P. Galmiche, R. Buelow, Arnaud Bourreille

Publikováno v: Scandinavian journal of gastroenterology. 38(5)

Tumour necrosis factor (TNF) plays a key role in the pathogenesis of Crohn disease (CD). RDP58 is a novel anti-inflammatory decapeptide which was developed using a novel rational design strategy. Recently, RDP58 has proved to be a potent inhibitor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57434416a031d3a73a38edbad0098f5f
https://pubmed.ncbi.nlm.nih.gov/28443774

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Rôle du stress du réticulum endoplasmique dans les modifications épigénétiques de l’épithélium colique induit par un retard de croissance intra-utérin chez le rat

Autor: Christian Bonnet, Jean-Pierre Segain, P. de Coppet, G. Le Dréan, A. Désir-Vigné, V. Haure-Mirande

Publikováno v: Les Journées Francophones de Nutrition Nutrition Clinique et Métabolisme
Les Journées Francophones de Nutrition Nutrition Clinique et Métabolisme, Dec 2015, Marseille, France. Nutrition Clinique et Métabolisme, 30 (1), 2016, ⟨10.1016/j.nupar.2016.01.008⟩

Introduction et but de l’etude Le butyrate joue un role important dans l’homeostasie de la barriere epitheliale colique (BEC) : c’est la source principale d’energie des cellules epitheliales du colon (CEC) mais aussi un regulateur epigenetiqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609fb49fa99e4bf13af63ecaa170bc2e
https://hal.inrae.fr/hal-02743326

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Déficit de transport du butyrate chez les patients atteints de maladies inflammatoires chroniques de l’intestin : implications cliniques et physiopathologiques

Autor: Ronan Thibault, Jean-Pierre Segain

Publikováno v: Nutrition Clinique et Métabolisme. 25:75-79

Resume Au debut des annees 1980, il etait suspecte que la rectocolite hemorragique (RCH) etait la consequence d’un deficit d’oxydation du butyrate dans la muqueuse colique, donc une maladie metabolique. Le butyrate, un acide gras a chaine courte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b04c23159cb9b04bd2abc7e18d98e39
https://doi.org/10.1016/j.nupar.2011.04.002

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Urotensin II is a New Chemotactic Factor for UT Receptor-Expressing Monocytes

Autor: Gervaise Loirand, Malvyne Rolli-Derkinderen, Diane Raingeard de la Blétière, Jean-Pierre Segain, Pierre Pacaud, Nadine Gervois

Publikováno v: The Journal of Immunology. 179:901-909

Urotensin II (U-II), a vasoactive cyclic neuropeptide which activates the G protein-coupled receptor UT receptor, exerts various cardiovascular effects and may play a role in the pathophysiology of atherosclerosis. In this study, we report that the U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d277513b65df35c7e31676c4516b94
https://doi.org/10.4049/jimmunol.179.2.901

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