Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Jean Pierre Savineau"'
Autor:
Daniel Henrion, Roger Marthan, Marilyne Campagnac, Thomas Ducret, Juliette Deweirdt, Jean-François Quignard, Isabelle Baudrimont, Jean-Pierre Savineau, Guillaume Gilbert, Audrey Lhomme, Thomas Pele, Christelle Guibert
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In intrapulmonary arteries (IPA), endothelial cells (EC) respond to mechanical stimuli by releasing vasoactive factors to set the vascular tone. Piezo1, a stretch-activated, calcium-permeable channel, is a sensor of mechanical stress in EC. The prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942c8f52f4bc151b3ba3f7bf0b62c441
https://doi.org/10.1165/rcmb.2018-0197oc
https://doi.org/10.1165/rcmb.2018-0197oc
Autor:
Véronique Freund-Michel, Christelle Guibert, Mathilde Dubois, Arnaud Courtois, Roger Marthan, Jean-Pierre Savineau, Bernard Muller
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 7 (2013)
Pulmonary hypertension (PH) is characterized by a progressive elevation of pulmonary arterial pressure due to alterations of both pulmonary vascular structure and function. This disease is rare but life-threatening, leading to the development of righ
Externí odkaz:
https://doaj.org/article/6f29c672da004472ae96316c3e4485eb
Autor:
Mathilde Dubois, Estelle Delannoy, Lucie Duluc, Ellen Closs, Huige Li, Christian Toussaint, Alain-Pierre Gadeau, Axel Gödecke, Véronique Freund-Michel, Arnaud Courtois, Roger Marthan, Jean-Pierre Savineau, Bernard Muller
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e82594 (2013)
Tetrahydrobiopterin (BH4), which fosters the formation of and stabilizes endothelial NO synthase (eNOS) as an active dimer, tightly regulates eNOS coupling / uncoupling. Moreover, studies conducted in genetically-modified models demonstrate that BH4
Externí odkaz:
https://doaj.org/article/daf2ff7938b441cca853d75689a580ad
Autor:
J. Deweirdt, Christelle Guibert, Sabrina Lacomme, I. Baudrimont, Jean-François Quignard, Roger Marthan, Jean-Pierre Savineau, Stéphane Mornet, E. Gontier
Publikováno v:
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94 (7), pp.2331-2348. ⟨10.1007/s00204-020-02764-9⟩
Archives of Toxicology, 2020, 94 (7), pp.2331-2348. ⟨10.1007/s00204-020-02764-9⟩
Archives of Toxicology, Springer Verlag, 2020, 94 (7), pp.2331-2348. ⟨10.1007/s00204-020-02764-9⟩
Archives of Toxicology, 2020, 94 (7), pp.2331-2348. ⟨10.1007/s00204-020-02764-9⟩
International audience; Human exposure to manufactured nanoparticles (NPs) is a public health concern. Endothelial cells lining the inner surface of arteries could be one of the primary targets for inhaled nanoparticles. Moreover, it is well known th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000849b2fa5fb14044c595520d10e4f6
http://hdl.handle.net/20.500.12278/15798
http://hdl.handle.net/20.500.12278/15798
Autor:
Paul Robillard, Raphaël Thuillet, Christophe Guignabert, Elise Maurat, Véronique Freund-Michel, Raffaella Soleti, Frederic Delcambre, Baptiste Rode, Ly Tu, Eric Dumas De La Roque, Patrick Berger, Carole Phan, Nafiisha Genet, Claire Bouvard, Roger Marthan, Marilyne Campagnac, Thibaud Parpaite, Christelle Guibert, Laurent Cronier, Jean-Pierre Savineau
Publikováno v:
European Respiratory Journal
European Respiratory Journal, European Respiratory Society, In press, pp.1900169. ⟨10.1183/13993003.00169-2019⟩
European Respiratory Journal, European Respiratory Society, 2020, 55 (3), pp.1900169. ⟨10.1183/13993003.00169-2019⟩
European Respiratory Journal, European Respiratory Society, In press, pp.1900169. ⟨10.1183/13993003.00169-2019⟩
European Respiratory Journal, European Respiratory Society, 2020, 55 (3), pp.1900169. ⟨10.1183/13993003.00169-2019⟩
The mechanisms underlying pulmonary hypertension (PH) are complex and multifactorial, and involve different cell types that are interconnected through gap junctional channels. Although connexin (Cx)-43 is the most abundant gap junction protein in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9348d9c5a1e2048f32415f1285b0a237
https://hal.univ-angers.fr/hal-02430904
https://hal.univ-angers.fr/hal-02430904
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6432 (2009)
BackgroundEndothelial control of vascular smooth muscle plays a major role in the resulting vasoreactivity implicated in physiological or pathological circulatory processes. However, a comprehensive understanding of endothelial (EC)/smooth muscle cel
Externí odkaz:
https://doaj.org/article/abbf1d29f549430c8c98828f024db484
Autor:
Jean-Pierre Savineau, Laure-Anne Cussac, Nichiren Tiruchellvam Pillai, Thomas Ducret, Philippe Gailly, Paul Robillard, G. Cardouat, Roger Marthan, Marilyne Campagnac, Anaïs Montillaud, Christelle Guibert, Jean-François Quignard
Publikováno v:
American Journal of Physiology: Lung Cellular and Molecular Physiology, Vol. 318, no.1, p. L135-L146 (2020)
Pulmonary arterial adventitial fibroblasts (PAF), the most abundant cellular constituent of adventitia, act as a key regulator of pulmonary vascular wall structure and function from the outside-in. Previous studies indicate that transient receptor po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d6aa9f6ca1864c84fa7639dd35cab1
https://pubmed.ncbi.nlm.nih.gov/31693393
https://pubmed.ncbi.nlm.nih.gov/31693393
Autor:
Isabelle Baudrimont, Jean-Pierre Savineau, Véronique Freund-Michel, Roger Marthan, Paul Robillard, Mathilde Dubois, Juliette Deweirdt, Christelle Guibert, Matthieu Douard, Bernard Muller
Publikováno v:
Pulmonary hypertension.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd345cffd576dd82c1ab46d94a66de1
https://doi.org/10.1183/13993003.congress-2018.oa3274
https://doi.org/10.1183/13993003.congress-2018.oa3274
Autor:
E. Gontier, Sabrina Lacomme, J. Sciare, Christelle Guibert, Arnaud Courtois, Bernard Muller, Isabelle Baudrimont, Juliette Deweirdt, Roger Marthan, Jean-Pierre Savineau, Armelle Baeza-Squiban, B. Crobeddu, Jean-François Quignard
Publikováno v:
Toxicology in Vitro
Toxicology in Vitro, 2017, 45, pp.340-350. ⟨10.1016/j.tiv.2017.07.001⟩
Toxicology in Vitro, Elsevier, 2017, 45, pp.340-350. ⟨10.1016/j.tiv.2017.07.001⟩
Toxicology in Vitro, 2017, 45, pp.340-350. ⟨10.1016/j.tiv.2017.07.001⟩
Toxicology in Vitro, Elsevier, 2017, 45, pp.340-350. ⟨10.1016/j.tiv.2017.07.001⟩
International audience; Recent studies have revealed that particulate matter (PM) exert deleterious effects on vascular function. Pulmonary artery endothelial cells (HPAEC), which are involved in the vasomotricity regulation, can be a direct target o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a17170b4073ddadf4f13a76b08dd9f
https://hal.science/hal-02439655/document
https://hal.science/hal-02439655/document
Autor:
Paul Robillard, Jennifer Gillibert-Duplantier, Thomas Ducret, Guillaume Cardouat, Jean-Pierre Savineau, Roger Marthan, Jean-François Quignard, Marthe Mauroux, Thibaud Parpaite
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:111-130
Transient receptor potential (TRP) channels of the vanilloid subfamily, mainly TRPV1 and TRPV4, are expressed in pulmonary artery smooth muscle cells (PASMC) and implicated in the remodeling of pulmonary artery, a landmark of pulmonary hypertension (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8ac140e447a4d09d4c9bb9efb4adaa
https://doi.org/10.1007/s00424-015-1704-6
https://doi.org/10.1007/s00424-015-1704-6