Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jean Pierre Revelli"'
Autor:
Won-Seok Lee, Ismael Al-Ramahi, Hyun-Hwan Jeong, Youjin Jang, Tao Lin, Carolyn J. Adamski, Laura A. Lavery, Smruti Rath, Ronald Richman, Vitaliy V. Bondar, Elizabeth Alcala, Jean-Pierre Revelli, Harry T. Orr, Zhandong Liu, Juan Botas, Huda Y. Zoghbi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Many neurodegenerative disorders are caused by abnormal accumulation of misfolded proteins. In spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded (polyQ-expanded) ataxin-1 (ATXN1) causes neuronal toxicity. Lowering total ATX
Externí odkaz:
https://doaj.org/article/15989ff1be9a4c33b23b168062a26a21
Autor:
Dah‐eun Chloe Chung, Jean‐Pierre Revelli, Ronald Richman, Hari K. Yalamanchili, Myoung‐Goo Kang, Alexander Han, Huda Y. Zoghbi
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb86bb239a27f50f2381c64c8aa6449
https://doi.org/10.1002/alz.059890
https://doi.org/10.1002/alz.059890
Autor:
Maxime WC Rousseaux, Jean-Pierre Revelli, Gabriel E Vázquez-Vélez, Ji-Yoen Kim, Evelyn Craigen, Kristyn Gonzales, Jaclyn Beckinghausen, Huda Y Zoghbi
Publikováno v:
eLife, Vol 7 (2018)
Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the
Externí odkaz:
https://doaj.org/article/9179566631054bf29ed0cce0e8d7d3e3
Autor:
Christopher M. DaCosta, Robert Brommage, Isaac Van Sligtenhorst, Zhi-Ming Ding, Gwenn M. Hansen, Kenneth A. Platt, Jean-Pierre Revelli, Deon Doree, David R. Powell
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:2641-2652
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1241da8071ecf353792b00269b89ba
https://doi.org/10.2147/dmso.s259546
https://doi.org/10.2147/dmso.s259546
Autor:
David R Powell, Deon D Doree, Christopher M DaCosta, Kenneth A Platt, Robert Brommage, Lindsey Buhring, Jean-Pierre Revelli, Melanie K Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.
David R Powell,1 Deon D Doree,1 Christopher M DaCosta,1 Kenneth A Platt,2 Robert Brommage,1 Lindsey Buhring,1 Jean-Pierre Revelli,1 Melanie K Shadoan1 1Department of Pharmaceutical Biology, Lexicon Pharmaceuticals, Inc, The Woodlands, TX, USA; 2Depar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33643fb27a8877ae6bb4e8757ee67c5
https://www.dovepress.com/mice-lacking-gpr75-are-hypophagic-and-thin-peer-reviewed-fulltext-article-DMSO
https://www.dovepress.com/mice-lacking-gpr75-are-hypophagic-and-thin-peer-reviewed-fulltext-article-DMSO
Autor:
Stephanie L. Coffin, Mark A. Durham, Larissa Nitschke, Eder Xhako, Amanda M. Brown, Jean-Pierre Revelli, Esmeralda Villavicencio Gonzalez, Tao Lin, Hillary P. Handler, Yanwan Dai, Alexander J. Trostle, Ying-Wooi Wan, Zhandong Liu, Roy V. Sillitoe, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
Neuron. 111:481-492.e8
Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d764b8ba9dcb0bfad8b1838a7961f4fe
https://doi.org/10.1016/j.neuron.2022.11.016
https://doi.org/10.1016/j.neuron.2022.11.016
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Robert, Brommage, Lindsey, Buhring, Jean-Pierre, Revelli, Melanie K, Shadoan
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose Humans with haploinsufficiency of GPR75, an orphan GPCR, are thin. Gpr75 knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm these findings in Gpr75 KO mice and determine whether decreased energy intake an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::297a542c63b91289d72014b3b34f4748
https://pubmed.ncbi.nlm.nih.gov/35023939
https://pubmed.ncbi.nlm.nih.gov/35023939
Autor:
David R, Powell, Deon D, Doree, Christopher M, DaCosta, Kenneth A, Platt, Gwenn M, Hansen, Isaac, van Sligtenhorst, Zhi-Ming, Ding, Jean-Pierre, Revelli, Robert, Brommage
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Purpose In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 (PRKD1) and G2/M-phase-specific E3 ubiquitin protein ligase (G2E3) genes on chromosome 14 are associated with obesity. To date, no published evidence links
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11ad3ff60e157b814ea6ccc362bf14f8
https://pubmed.ncbi.nlm.nih.gov/32801815
https://pubmed.ncbi.nlm.nih.gov/32801815
Autor:
Aleksandar Bajić, Kristyn Gonzales, Gabriel E. Vázquez-Vélez, Jean-Pierre Revelli, Sabrina M. Heman-Ackah, Carolyn J. Adamski, Ronald Richman, Maxime W.C. Rousseaux, Evelyn Craigen, Fatemeh Alavi Naini, Matthew J.A. Wood, Huda Y. Zoghbi
Publikováno v:
J Neurosci
α-Synuclein (α-Syn) accumulation is a pathological hallmark of Parkinson's disease. Duplications and triplications ofSNCA, the gene coding for α-Syn, cause genetic forms of the disease, which suggests that increased α-Syn dosage can drive PD. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa8e67680e871a6bb332ee727c4eff6
https://doi.org/10.1523/jneurosci.1076-19.2019
https://doi.org/10.1523/jneurosci.1076-19.2019
Autor:
Gabriel E. Vázquez-Vélez, Evelyn Craigen, Jean-Pierre Revelli, Ji-Yoen Kim, Maxime W.C. Rousseaux, Kristyn Gonzales, Jaclyn Beckinghausen, Huda Y. Zoghbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05878daddd350cbd316bb3f7a09e9dcc
https://doi.org/10.7554/elife.36768.017
https://doi.org/10.7554/elife.36768.017