Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Jean Pierre Gesson"'
Publikováno v:
E-Journal of Chemistry, Vol 8, Iss 3, Pp 1394-1400 (2011)
Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analog
Externí odkaz:
https://doaj.org/article/82c3704bd4b24635a20202a526a83e50
Publikováno v:
E-Journal of Chemistry, Vol 8, Iss S1, Pp S79-S84 (2011)
The inhibition of HDAC (histone deacetylase) activity by specific inhibitors induces growth arrest, differentiation and apoptosis of transformed or several cancer cells. Some of these inhibitors are in clinical trial at phase I or phase II. The disco
Externí odkaz:
https://doaj.org/article/995007e3bd534c1cb5cd67c62251c4ac
Publikováno v:
Journal of Clinical Haematology. 1
Publikováno v:
Carbohydrate research. 487
N-ribosylation and N-mannosylation compounds have a great role in compounds activity as anticancer. The reaction of 2-thioxo-4-thiazolidinone (rhodanine) derivatives, as aglycon part, was done with ribofuranose and mannopyranose sugars (glycone part)
Autor:
Ramona Barbour Eisen, Rodolphe Vauzelle, Lamine Boubakar, Yves Bertrand, Sylvie Pautrot, Jean-Pierre Gesson
Publikováno v:
Journal of the European Honors Council, Vol 2, Iss 1 (2018)
In this paper, we will describe the Cursus Master en Ingénierie (CMI) program, as well as the Formation à l’InGénierie par des Universités de REcherche (FIGURE) university network, and analyze its development and place in the French higher educ
Publikováno v:
E-Journal of Chemistry, Vol 8, Iss 3, Pp 1394-1400 (2011)
Inhibitors of histone deacetylases (HDACs) are patent inducers of differentiation and bear considerable potential as drugs for chemoprevention and treatment of cancer. In this paper, we have investigated three synthetic, inhibitors A1a,b, A2a. Analog
Autor:
Jean Pierre Gesson, Philippe Bertrand
Publikováno v:
The Journal of Organic Chemistry. 72:3596-3599
Click chemistry has became an important tool for molecular constructs such as biopolymers. During the development of biodegradable multifunctional poly(ethylene oxide) (PEO) polymers suitable for click chemistry in water, an unexpected reaction leadi
Publikováno v:
Tetrahedron Letters. 47:9305-9308
An efficient method for the synthesis of antitumor TMC-69-6H and related analogs which have been demonstrated to be phosphatase (PTP1B, VHR, and PP1) inhibitors, is reported. This strategy involves two key steps: a diastereoselective aldol reaction a
Autor:
Jean-Pierre Gesson, Ulrich Koert, Christelle Faveau, Sandra Gebhardt, Tobias Mahnke, Martine Mondon
Publikováno v:
Tetrahedron Letters. 47:8305-8308
An analogue of the paclitaxel-like antimicrotubule agent laulimalide with a phenyl in place of the dihydropyran has been synthesized. The fragments C 1 –C 14 and C 15 –C 28 were coupled via a stereoselective intermolecular allylboration. Ring clo
Publikováno v:
Tetrahedron Letters. 47:5547-5551
Treatment of 1-bromopropargylic amines affords the corresponding 1,1,1-trifluoro in one step in HF–SbF5 medium. 1-Bromo-1,1-difluoro or 2-bromo-1,1,1-trifluoro derivatives could also be prepared, depending on the reaction conditions.