Selective inhibition of intestinal guanosine 3,5-cyclic monophosphate signaling by small-molecule protein kinase inhibitors

Autor: Marcel J. C. Bijvelds, Natascha D.A. Nieuwenhuijze, Karine Smans, Kelly F. Meijsen, Ann Hellemans, Gary Tresadern, Joris H. De Maeyer, Jean-Pierre Bongartz, Hugo R. de Jonge, Luc Ver Donck, Jan A.J. Schuurkes

Publikováno v: Journal of Biological Chemistry, 293(21), 8173-8181. American Society for Biochemistry and Molecular Biology Inc.
The Journal of Biological Chemistry

The guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC) to control intestinal fluid homeostasis. Here, we report the discovery of small-molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1ee4a8f9967179af8984be752279ac
https://hdl.handle.net/1765/107349

pH-Sensitive Liposomes and Antisense Oligonucleotide Delivery

Autor: Jean R. Philippot, Pierre G. Milhaud, Bernard Lebleu, Jean Pierre Bongartz

Publikováno v: Drug Delivery. 3:67-73

J. R. Philippot and B. Lebleu acknowledge the Agence Nationale de Recherche sur le SIDA and the Association de Recherche contre le Cancer for support. The authors thank A. Bienveniie from URA-CNRS 1856 (University Montpellier II) for many fruitful di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aadcbb427a4dc63f451462d9f0fe27d
https://doi.org/10.3109/10717549609031175

Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives

Autor: Ceusters Marc Andre, Marcel Gerebernus Maria Luyckx, Wouters Walter Boudewijn Leopo, Raymond Antoine Stokbroekx, Marcel Jozef Maria Van Der Aa, Mark Herb, Gerda Smets, Jean-Pierre Bongartz, Lieven Meerpoel, Charlie Bowden, Lisa Valletta, Rose Tominovich, Tuman Robert W, Marc Willems, Tine Jansen

Publikováno v: Bioorganicmedicinal chemistry letters. 12(4)

General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a339ae563fd1d8549c036d23eb9cb3b0
https://pubmed.ncbi.nlm.nih.gov/11844678

SYNTHESIS OF α-HALOGENATED METHANEDIPHOSPHONATES1a, b

Autor: Jean-Pierre Bongartz, Phuong Truc T. Pham, Wan-Yaacob Ahmad, Leslie A. Khawli, Charles E. McKenna

Publikováno v: Phosphorous and Sulfur and the Related Elements. 37:1-12

Methanediphospnonate (MDP) anions can exhibit anti-viral activity, inhibit bone resorption, and act as ligands in radiopharmaceuticals. α-Halo-substitution provides MDP derivatives (XYMDP, where × = H, F, CI or Br; Y = F, Cl or Br) with modified ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73369aef7b239d1a161c9d90adbd2d7f
https://doi.org/10.1080/03086648808074346