HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

Autor: Francesca Fiorini, Jean-Philippe Robin, Joanne Kanaan, Malgorzata Borowiak, Vincent Croquette, Hervé Le Hir, Pierre Jalinot, Vincent Mocquet

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translo

Externí odkaz: https://doaj.org/article/cee99c9cf6b9423fa0e3aee0a205c4f9

Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias

Autor: Maroun Karam, Morgan Thenoz, Valérie Capraro, Jean-Philippe Robin, Christiane Pinatel, Agnès Lançon, Perrine Galia, David Sibon, Xavier Thomas, Sophie Ducastelle-Lepretre, Franck Nicolini, Mohamed El-Hamri, Youcef Chelghoun, Eric Wattel, Franck Mortreux

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 1, Pp 21-30 (2014)

Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells

Externí odkaz: https://doaj.org/article/9a70383a39c5494e816703b18ee8b225

Cloud comuting case studies and applications for the space and security domain

Autor: Anca Popescu, Adrian Luna, Sergio Albani, Vasileios Kalogirou, Jean-Philippe Robin

Publikováno v: Conference proceedings published by the Joint Research Centre (JRC), the European Commission’s science and knowledge service.
Proc. of the 2019 conference on Big Data from Space (BiDS’2019), EUR 29660 EN, ISBN 978-92-76-00034-1, doi:10.2760/848593Conference on Big Data from Space (BiDS19), Munich, Germany, 2019-02-19-2019-02-21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::fcd02956b4a63f050179180db12a556e

The Human T-Lymphotropic Virus Type 1 Tax Protein Inhibits Nonsense-Mediated mRNA Decay by Interacting with INT6/EIF3E and UPF1

Autor: Jürgen Wittmann, Madeleine Duc Dodon, Hervé Le Hir, Julia Neusiedler, Pierre Jalinot, Francesca Rende, Vincenzo Ciminale, Vincent Mocquet, Jean Philippe Robin, Jean-Michel Terme, Christelle Morris, David Cluet

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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In this report, we analyzed whether the degradation of mRNAs by the nonsense-mediated mRNA decay (NMD) pathway was affected in human T-lymphotropic virus type 1 (HTLV-1)-infected cells. This pathway was indeed strongly inhibited in C91PL,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e183dd0432567db89f0303d8123f22c
https://europepmc.org/articles/PMC3416306/

Inhibition of HIV-1 replication by cell-penetrating peptides binding rev

Autor: Jean-Philippe Robin, Dominique Dormont, Nathalie Dereuddre-Bosquet, Armelle Roisin, Pierre Jalinot, Pascal Clayette, Anne-Laure Vitte

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2004, 279 (10), pp.9208-9214. ⟨10.1074/jbc.M311594200⟩
Journal of Biological Chemistry 10 (279), 9208-9214. (2004)
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (10), pp.9208-9214. ⟨10.1074/jbc.M311594200⟩

International audience; New therapeutic agents able to block HIV-1 replication are eagerly sought after to increase the possibilities of treatment of resistant viral strains. In this report, we describe a rational strategy to identify small peptide s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ab9dd1523a67ea144bd3b140a46f09
https://hal.inrae.fr/hal-02680967