Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jean Philippe Coppé"'
Autor:
Valentin Feichtenschlager, Linan Chen, Yixuan James Zheng, Wilson Ho, Martina Sanlorenzo, Igor Vujic, Eleanor Fewings, Albert Lee, Christopher Chen, Ciara Callanan, Kevin Lin, Tiange Qu, Dasha Hohlova, Marin Vujic, Yeonjoo Hwang, Kevin Lai, Stephanie Chen, Thuan Nguyen, Denise P Muñoz, Yoshinori Kohwi, Christian Posch, Adil Daud, Klemens Rappersberger, Terumi Kohwi-Shigematsu, Jean-Philippe Coppé, Susana Ortiz-Urda
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using a discovery approach combining experimental models and
Externí odkaz:
https://doaj.org/article/d39bbf99048b49ce889263e2e9a46308
Autor:
Monica Capogiri, Andrea J. De Micheli, Alvaro Lassaletta, Denise P. Muñoz, Jean-Philippe Coppé, Sabine Mueller, Ana S. Guerreiro Stucklin
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
BRAFV600E represents the most common BRAF mutation in all human cancers. Among central nervous system (CNS) tumors, BRAFV600E is mostly found in pediatric low-grade gliomas (pLGG, ~20%) and, less frequently, in pediatric high-grade gliomas (pHGG, 5-1
Externí odkaz:
https://doaj.org/article/37b0c4f9e688407bba02ad40cf65caf6
Autor:
Ana Ruiz-Saenz, Chloe E. Atreya, Changjun Wang, Bo Pan, Courtney A. Dreyer, Diede Brunen, Anirudh Prahallad, Denise P. Muñoz, Dana J. Ramms, Valeria Burghi, Danislav S. Spassov, Eleanor Fewings, Yeonjoo C. Hwang, Cynthia Cowdrey, Christina Moelders, Cecilia Schwarzer, Denise M. Wolf, Byron Hann, Scott R. VandenBerg, Kevan Shokat, Mark M. Moasser, René Bernards, J. Silvio Gutkind, Laura J. van ‘t Veer, Jean-Philippe Coppé
Publikováno v:
Nature cancer, vol 4, iss 2
Nature Cancer, 4(2), 240-256. Nature Research
Nature Cancer, 4(2), 240-256. Nature Research
BRAFV600E mutation confers a poor prognosis in metastatic colorectal cancer (CRC) despite combinatorial targeted therapies based on the latest understanding of signaling circuitry. To identify parallel resistance mechanisms induced by BRAF–MEK–EG
Autor:
Fei Chen, Qilai Long, Da Fu, Dexiang Zhu, Yan Ji, Liu Han, Boyi Zhang, Qixia Xu, Bingjie Liu, Yan Li, Shanshan Wu, Chen Yang, Min Qian, Jianmin Xu, Suling Liu, Liu Cao, Y. Eugene Chin, Eric W.-F. Lam, Jean-Philippe Coppé, Yu Sun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Tumour microenvironment actively contributes to drug resistance in clinical oncology. Here, the authors show that genotoxic stress induces senescence in human stromal cells, which in turn secrete serine protease inhibitor Kazal type 1 (SPINK1) and pr
Externí odkaz:
https://doaj.org/article/814d6dc53fea4b498e4d863a03b8fd96
Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors
Autor:
Imke H. Bartelink, Brendan Prideaux, Gregor Krings, Lisa Wilmes, Pei Rong Evelyn Lee, Pan Bo, Byron Hann, Jean-Philippe Coppé, Diane Heditsian, Lamorna Swigart-Brown, Ella F. Jones, Sergey Magnitsky, Ron J Keizer, Niels de Vries, Hilde Rosing, Nela Pawlowska, Scott Thomas, Mallika Dhawan, Rahul Aggarwal, Pamela N. Munster, Laura J. Esserman, Weiming Ruan, Alan H. B. Wu, Douglas Yee, Véronique Dartois, Radojka M. Savic, Denise M. Wolf, Laura van ’t Veer
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-17 (2017)
Abstract Background Poly(ADP-ribose) polymerase inhibitors (PARPi), coupled to a DNA damaging agent is a promising approach to treating triple negative breast cancer (TNBC). However, not all patients respond; we hypothesize that non-response in some
Externí odkaz:
https://doaj.org/article/36493b79564d44c2b1b8ca3d6cd7f195
Autor:
Jean-Philippe Coppé, Laura J. van ‘t Veer, Lamorna Brown-Swigart, Evelyn Pei Rong Lee, Aleksandr Pankov, Christina Yau, Denise M. Wolf, R. Hannes Niedner, Zhongzhong Chen, Aleksandra Olow
Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps of kinase circui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c624c10b88a453d8ccd2b639c7514a
https://doi.org/10.1158/0008-5472.c.6507657
https://doi.org/10.1158/0008-5472.c.6507657
Autor:
Jean-Philippe Coppé, Laura J. van ‘t Veer, Lamorna Brown-Swigart, Evelyn Pei Rong Lee, Aleksandr Pankov, Christina Yau, Denise M. Wolf, R. Hannes Niedner, Zhongzhong Chen, Aleksandra Olow
Legends for Supplementary Figures S1-S17.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c209bc86ffaa2cd9327d53fd541ed5
https://doi.org/10.1158/0008-5472.22408989.v1
https://doi.org/10.1158/0008-5472.22408989.v1
Autor:
Jean-Philippe Coppé, Laura J. van ‘t Veer, Lamorna Brown-Swigart, Evelyn Pei Rong Lee, Aleksandr Pankov, Christina Yau, Denise M. Wolf, R. Hannes Niedner, Zhongzhong Chen, Aleksandra Olow
Phospho-reactome curation workflow (S1); Proteins catalogued in PhosphoAtlas correspond to a unique subset of Protein-Protein Interactions, defined by their active, proven function in phospho-catalytic events (S2); Comparative connectivity between ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aecfb1c145c04d53da2818f9a9f166
https://doi.org/10.1158/0008-5472.22408986.v1
https://doi.org/10.1158/0008-5472.22408986.v1
Autor:
Jean-Philippe Coppé, Laura J. van ‘t Veer, Lamorna Brown-Swigart, Evelyn Pei Rong Lee, Aleksandr Pankov, Christina Yau, Denise M. Wolf, R. Hannes Niedner, Zhongzhong Chen, Aleksandra Olow
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb2137c56483719b87cfa8fff60243e
https://doi.org/10.1158/0008-5472.22408983.v1
https://doi.org/10.1158/0008-5472.22408983.v1
Autor:
Valentin Feichtenschlager, Linan Chen, Yixuan Zheng, Wilson Ho, Martina Sanlorenzo, Igor Vujic, Eleanor Fewings, Albert Lee, Christopher Chen, Kevin Lin, Ciara Callanan, Marin Vujic, Yeonjoo Hwang, Kevin Lai, Stephanie Chen, Thuan Nguyen, Denise Muñoz, Yoshinori Kohwi, Christian Posch, Adil Daud, Klemens Rappersberger, Terumi Kohwi-Shigematsu, Jean-Philippe Coppé, Susana Ortiz-Urda
MAPK-pathway up-regulation is responsible for over 40% of human cancer cases. Finding effective therapeutic targets for melanoma therapy continues to be a challenge due to drug resistance. Using a computational and experimental pipeline, we discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249eaa59ad33bbcbb47ccfffceaf86f4
https://doi.org/10.21203/rs.3.rs-1297358/v1
https://doi.org/10.21203/rs.3.rs-1297358/v1