Poor Patient and Graft Outcome After Induction Treatment by Antithymocyte Globulin in Recipients of a Kidney Graft After Nonrenal Organ Transplantation

Autor: Hoa Le Mai, PhD, Michèle Treilhaud, MD, Shani Leviatan Ben-Arye, PhD, Hai Yu, PhD, Hélène Perreault, PhD, Evelyn Ang, PhD, Katy Trébern-Launay, PhD, Julie Laurent, PhD, Stéphanie Malard-Castagnet, PhD, Anne Cesbron, MD, Thi Van Ha Nguyen, PhD, Sophie Brouard, PhD, Lionel Rostaing, MD, Pauline Houssel-Debry, MD, Christophe Legendre, MD, Sophie Girerd, MD, Michèle Kessler, MD, Emmanuel Morelon, MD, Antoine Sicard, MD, Valérie Garrigue, MD, Georges Karam, MD, Xi Chen, PhD, Magali Giral, MD, Vered Padler-Karavani, PhD, Jean Paul Soulillou, MD

Publikováno v: Transplantation Direct, Vol 4, Iss 4, p e357 (2018)

Background. End-stage renal failure occurs in a substantial number of patients having received a nonrenal transplantation (NRT), for whom a kidney transplantation is needed. The medical strategy regarding the use of immunosuppression (IS) for a kidne

Externí odkaz: https://doaj.org/article/c100cca4bfe24f5f9ebdfabf66a148ab

Case Report: Long-term observations from the tacrolimus weaning randomized clinical trial depicts the challenging aspects for determination of low-immunological risk patients

Autor: Christophe Masset, Jacques Dantal, Jean-Paul Soulillou, Alexandre Walencik, Florent Delbos, Sophie Brouard, Magali Giral, the Nantes DIVAT Consortium, Gilles Blancho, Julien Branchereau, Diego Cantarovich, Anne Cesbron, Agnès Chapelet, Anne Devis, Clément Deltombe, Lucile Figueres, Raphael Gaisne, Claire Garandeau, Caroline Gourraud-Vercel, Maryvonne Hourmant, Christine Kandel-Aznar, Georges Karam, Clarisse Kerleau, Delphine Kervella, Claire Leman, Alice Leclech, Aurélie Meurette, Karine Renaudin, Simon Ville

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Whilst calcineurin inhibitors (CNI) are the cornerstone of immunosuppressive maintenance therapy in kidney transplantation, several studies have investigated the safety of CNI withdrawal in order to avoid their numerous side effects. In this context,

Externí odkaz: https://doaj.org/article/97e0e49619df4ea7887b19217b945162

Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study

Autor: Manuel Galiñanes, Kelly Casós, Arnau Blasco-Lucas, Eduard Permanyer, Rafael Máñez, Thierry Le Tourneau, Jordi Barquinero, Simo Schwartz, Tomaso Bottio, Jean Christian Roussel, Imen Fellah-Hebia, Thomas Sénage, Arturo Evangelista, Luigi P. Badano, Alejandro Ruiz-Majoral, Cesare Galli, Vered Padler-Karavani, Jean-Paul Soulillou, Xavier Vidal, Emanuele Cozzi, Cristina Costa

Publikováno v: Biomolecules, Vol 12, Iss 11, p 1606 (2022)

The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A)

Externí odkaz: https://doaj.org/article/722a6f5b2f424ca9a7df24370ed26755

Aglycosylated extracellular loop of inwardly rectifying potassium channel 4.1 (KCNJ10) provides a target for autoimmune neuroinflammation

Autor: Arnaud B Nicot, Jean Harb, Alexandra Garcia, Flora Guillot, Hoa-Le Mai, Camille V Mathé, Jérémy Morille, Amélie Vallino, Emilie Dugast, Sita P Shah, Fabienne Lefrère, Mélinda Moyon, Sandrine Wiertlewski, Ludmilla Le Berre, Karine Renaudin, Jean-Paul Soulillou, Vincent van Pesch, Sophie Brouard, Laureline Berthelot, David-Axel Laplaud

Publikováno v: Brain communications, Vol. 5, no.2, p. fcad044 (2023)

Multiple sclerosis is an autoimmune disease of the central nervous system. Yet, the autoimmune targets are still undefined. The extracellular e1 sequence of KCNJ10, the inwardly rectifying potassium channel 4.1, has been subject to fierce debate for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b08e80e2d7a198dceb59d43776d6022
https://hdl.handle.net/2078.1/276387

Interleukin-7 receptor blockade by an anti-CD127 monoclonal antibody in nonhuman primate kidney transplantation

Autor: Thi Van Ha Nguyen, Jeremy Hervouet, Hoa Le Mai, Nicolas Poirier, Jean-Paul Soulillou, David Minault, Julien Branchereau, Gilles Blancho, Caroline Mary, Karine Renaudin, Lyssia Belarif, Sophie Brouard, Bernard Vanhove, Stéphanie Le Bas-Berdardet

Publikováno v: American Journal of Transplantation
American Journal of Transplantation, 2019, ⟨10.1111/ajt.15543⟩
American Journal of Transplantation, Wiley, 2019, ⟨10.1111/ajt.15543⟩

International audience; IL‐7 is an important cytokine for T cell lymphopoiesis. Blockade of the IL‐7 signal‐ing pathway has been shown to induce long‐term graft survival or graft tolerance in murine transplant models through inhibiting T cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a68b2d7996d694566972c1dec2d25
https://doi.org/10.1111/ajt.15543