Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jean Paul Chadarevian"'
Autor:
Armine Hovakimyan, Garri Chilingaryan, Olga King, Joia Kai Capocchi, Jean Paul Chadarevian, Hayk Davtyan, Roman Kniazev, Michael G. Agadjanyan, Anahit Ghochikyan
Publikováno v:
Vaccines, Vol 12, Iss 6, p 659 (2024)
The escalating global healthcare challenge posed by Alzheimer’s Disease (AD) and compounded by the lack of effective treatments emphasizes the urgent need for innovative approaches to combat this devastating disease. Currently, passive and active i
Externí odkaz:
https://doaj.org/article/6dbc379834d3469bb2ed11cb139b6d6a
Autor:
Jean Paul Chadarevian, Hayk Davtyan, Sonia I. Lombroso, F. Chris Bennett, Mathew Blurton-Jones
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102490- (2023)
Summary: Chimeric mouse models have recently been developed to study human microglia in vivo. However, widespread engraftment of donor microglia within the adult brain has been challenging. Here, we present a protocol to introduce the G795A point mut
Externí odkaz:
https://doaj.org/article/ab58724d49b040f8b0f8e037c243fe92
Autor:
Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E. England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan, Mathew Blurton-Jones
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Disease-associated microglia (DAMs), that surround beta-amyloid plaques, represent a transcriptionally-distinct microglial profile in Alzheimer’s disease (AD). Activation of DAMs is dependent on triggering receptor expressed on
Externí odkaz:
https://doaj.org/article/c0e75e997897499ba66b3c9ec6115f97
Autor:
Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C. Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A. Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jones
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110961- (2022)
Summary: Microglia are strongly implicated in the development and progression of Alzheimer’s disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetica
Externí odkaz:
https://doaj.org/article/def9c689b7ba47e59182ba5cb0a6929b
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d74b2e4cb1a84ae98fd95f8389c0a7c0
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions
Externí odkaz:
https://doaj.org/article/2fc5155c4b834bdf97f0aa5db0218942
Autor:
Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan
Publikováno v:
eLife, Vol 11 (2022)
The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD
Externí odkaz:
https://doaj.org/article/69b87460172149e083d3a847b9a787f6
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 732-741 (2017)
Mouse epiblast stem cells (mEpiSCs) and human embryonic stem cells (hESCs) are primed pluripotent stem cells whose self-renewal can be maintained through cytoplasmic stabilization and retention of β-catenin. The underlying mechanism, however, remain
Externí odkaz:
https://doaj.org/article/414631d1e9544a35a7e51de1ed0618b0
Autor:
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Publikováno v:
Alzheimer's & Dementia. 18:1765-1778
The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology remains unknown. Chimeric AD and wild-type mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463825c6c305b25a2f0c80da82f03755
https://doi.org/10.1002/alz.12577
https://doi.org/10.1002/alz.12577
Autor:
Jean Paul Chadarevian, Sonia I. Lombroso, Graham C. Peet, Jonathan Hasselmann, Christina Tu, Dave E. Marzan, Joia Capocchi, Freddy S. Purnell, Kelsey M. Nemec, Alina Lahian, Adrian Escobar, Whitney England, Sai Chaluvadi, Carleigh A. O’Brien, Fazeela Yaqoob, William H. Aisenberg, Matias Porras-Paniagua, Mariko L. Bennett, Hayk Davtyan, Robert C. Spitale, Mathew Blurton-Jones, F. Chris Bennett
Publikováno v:
The Journal of experimental medicine, vol 220, iss 3
Hematopoietic stem cell transplantation (HSCT) can replace endogenous microglia with circulation-derived macrophages but has high mortality. To mitigate the risks of HSCT and expand the potential for microglia replacement, we engineered an inhibitor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd65ad6d31edb76b5662aa014420241f
https://doi.org/10.1084/jem.20220857
https://doi.org/10.1084/jem.20220857