Gene expression signature predicts rate of type 1 diabetes progressionResearch in context

Autor: Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers

Publikováno v: EBioMedicine, Vol 92, Iss , Pp 104625- (2023)

Summary: Background: Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed to identify transcriptional changes associated with the disease progress

Externí odkaz: https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Autor: Joëlle Vinh, Aurore Pais, Sylvaine You, Etienne Larger, Decio L. Eizirik, Maikel Luis Colli, Laure Alexandre-Heymann, Danièle Dubois-Laforgue, Roberto Mallone, Søren Buus, Georgia Afonso, Graziella Bruno, Mahmoud Tarayrah, Cassandra Lavaud, Gonzalez-Duque Sergio, Jean-Paul Beressi, Sheena Pinto, Marie Eliane Azoury, Claire Maillard, Verdier Yann

Publikováno v: Diabetes
Diabetes, 2020, 69 (12), pp.2678-2690. ⟨10.2337/db20-0013⟩
Diabetes, American Diabetes Association, 2020, 69 (12), pp.2678-2690. ⟨10.2337/db20-0013⟩

The antigenic peptides processed by β cells and presented through surface HLA Class I molecules are poorly characterized. Each HLA variant, e.g. the most common HLA-A2 and HLA-A3, carries some peptide-binding specificity. Hence, features that, despi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1a19452588c10d10f72a2c18829d5e
https://www.hal.inserm.fr/inserm-03312401

Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

Autor: Matthias Kuhn, Karen Cerosaletti, Anna Lissina, Georgia Afonso, Raphael Scharfmann, Jean-Paul Beressi, Etienne Larger, Francesco Dotta, Bruno Kyewski, Laura Nigi, Howard W. Davidson, Guido Sebastiani, David Price, Manuela Battaglia, Roberto Mallone, Søren Buus, Klaudia Kuranda, Sheena Pinto, Slobodan Culina, Ezio Bonifacio, James E. McLaren, Victor Appay, Ana Inés Lalanne, Thomas Osterbye, Kristin Ladell, Sophie Caillat-Zucman, Anne Eugster, Alicia Maugein

Publikováno v: Science Immunology
Science Immunology, 2018, 3 (20), ⟨10.1126/sciimmunol.aao4013⟩
Science Immunology, American Association for the Advancement of Science, 2018, 3 (20), ⟨10.1126/sciimmunol.aao4013⟩

International audience; The human leukocyte antigen-A2 (HLA-A2)-restricted zinc transporter 8186-194 (ZnT8186-194) and other islet epitopes elicit interferon-γ secretion by CD8+ T cells preferentially in type 1 diabetes (T1D) patients compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787a7fec2e9c93b9cae858cfe4689cda
https://www.hal.inserm.fr/inserm-01918833/document

Exenatide efficacy in unselected patients: Comparison with clinical trials

Autor: Virginie Desforges-Bullet, Gwenaelle Petit-Aubert, Carole Collet-Gaudillat, Jean Paul Beressi

Publikováno v: Journal of Diabetes Mellitus. :118-121

Exenatide is a Glucagon-Like Peptide-1 (GLP-1) analog improving fasting and post-prandial glycaemia, approved in patients treated with a combination of sulfonylureas and metformin and not achieving good metabolic control. This retrospective cohort st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87f84bb88dc5620211e85e7de77838c1
https://doi.org/10.4236/jdm.2012.21019

Short‐ and long‐term follow‐up of thyroid dysfunction after allogeneic bone marrow transplantation without the use of preparative total body irradiation

Autor: Eliane Gluckman, Selim Aractingi, Gérard Socié, Marie-Helene Schlageter, Helene Esperou, Marie-Elisabeth Toubert, Patrick Vexiau, Jean-Didier Rain, Agnès Devergie, Patricia Ribaud, Jean‐Paul Beressi, Nathalie Parquet

Publikováno v: British Journal of Haematology. 98:453-457

We studied the incidence and potential prognostic value of thyroid abnormalities after allogeneic bone marrow transplantation (BMT) without total body irradiation (TBI) conditioning. 77 consecutive patients who received a chemotherapy-alone-based con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eae1ff04a221c586d8789eafabc531b
https://doi.org/10.1046/j.1365-2141.1997.2433060.x