Early Hypoexcitability in a Subgroup of Spinal Motoneurons in Superoxide Dismutase 1 Transgenic Mice, a Model of Amyotrophic Lateral Sclerosis

Autor: Sylvie Liabeuf, Anton Filipchuk, Jean Patrick Gueritaud, Arnaud Pambo-Pambo, Fanny Gaudel, Cécile Brocard, Jacques Durand

Publikováno v: Neuroscience
Neuroscience, Elsevier-International Brain Research Organization, 2021, 463, pp.337-353. ⟨10.1016/j.neuroscience.2021.01.039⟩
Neuroscience, 2021, 463, pp.337-353. ⟨10.1016/j.neuroscience.2021.01.039⟩

International audience; In amyotrophic lateral sclerosis (ALS), large motoneurons degenerate first, causing muscle weakness. Transgenic mouse models with a mutation in the gene encoding the enzyme superoxide dismutase 1 (SOD1) revealed that motoneuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a09baef43d4c54bb0ff9ced513ed52c
https://hal.archives-ouvertes.fr/hal-03223234

Electrical properties and morphology of motoneurons developing in dissociated unpurified co-culture of the embryonic rat brainstem, spinal cord, and hindlimb tissues

Autor: Thomas Launey, S. M. Korogod, Jean-Patrick Gueritaud, A. I. Ivanov

Publikováno v: Neurophysiology. 30:305-309

Experimental measurements of the input resistance were performed using a whole-cell patch-clamp recording technique of presumed motoneurons in unpurified co-culture of the dissociated prenatal rat brainstem, spinal cord, and hindlimb muscle tissues a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::773c37ec19319b71af4424c19af09749
https://doi.org/10.1007/bf02462844

Barium-induced bistability in rat ocular motoneurones in vitro

Autor: Jean-Patrick Gueritaud

Publikováno v: Neuroscience Letters. 170:158-162

Intracellular recordings were obtained from adult rat oculomotor neurones in an in vitro brainstem slice preparation. In motoneurones hyperpolarized to levels below −90 mV, depolarizing current injections induced voltage-dependent low-threshold pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b9c560c0679684814bd30877e47ab7
https://doi.org/10.1016/0304-3940(94)90263-1

Differential modulation of the GYKI 53784-induced inhibition of AMPA currents by various AMPA-positive modulators in cerebellar Purkinje cells

Autor: Gabor Kapus, Ágnes Pataki, Jean-Patrick Gueritaud, Ilona Bódi, István Tarnawa, József I. Székely

Publikováno v: European journal of pharmacology. 397(1)

The effects of various (S)-α-amino-3-hydroxy-5-methyl-4-izoxazole-propionate (AMPA) receptor modulators on AMPA-induced whole-cell currents were compared in isolated rat cerebellar Purkinje cells. The positive modulators, aniracetam, cyclothiazide,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5370e404a2b76ddda16257ab49bdc15e
https://pubmed.ncbi.nlm.nih.gov/10844097