Výsledky vyhledávání

HT29‐MTX and Caco‐2/TC7 Monolayers as Predictive Models for Human Intestinal Absorption: Role of the Mucus Layer

Autor: Bernard Lenfant, Philippe Arnaud, Jean Pachot, Catherine Pontier, Roger P. Botham

Publikováno v: Journal of Pharmaceutical Sciences. 90:1608-1619

The permeability of 19 compounds in both the Caco-2/TC7 and HT29-MTX models was determined, and the ability of each model to predict intestinal absorption in humans was compared. Similar apparent permeability values (log P(app)) were obtained in both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc0888a4821f909a64f72b225809fea
https://doi.org/10.1002/jps.1111

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Absorption of angiotensin II antagonists in Ussing chambers, Caco-2, perfused jejunum loop and in vivo

Autor: Jean Pachot, Klaus D. Haegele, Roger P. Botham, Bernard Lenfant, Michel Boisset

Publikováno v: European Journal of Pharmaceutical Sciences. 10:215-224

The aims of this study were (i) to compare the absorption of three closely related inhibitors of angiotensin II, RU60018, RU60079 and HR720, in various in vitro and in vivo models, and (ii) to explain the differences in the results and to assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dcb27ea19ac2066e43fa4b3b0d726c0
https://doi.org/10.1016/s0928-0987(00)00073-7

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A catch-up validation study on reconstructed human epidermis (SkinEthic RHE) for full replacement of the Draize skin irritation test

Autor: Olivier Doucet, Jean Pachot, Cécile Robert, Carole Amsellem, Marisa Meloni, Nathalie Alépée, Anne de Brugerolle de Fraissinette, Marie-Hélène Roux, Carine Tornier

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 24(1)

Efforts to fully replace the in vivo Draize skin irritation test, according to the Directive 67/548/ECC or OECD TG 404, were reinforced with the seventh Amendment of the Cosmetic Directive and the REACh regulation. In 2007, the EpiSkin test method wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f819c9188955409900985eadd10499c
https://pubmed.ncbi.nlm.nih.gov/19733228

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CYP450 characterization of the reconstructed human epidermis Episkin™ involved in xenobiotic metabolism

Autor: Van Luu-The, Fernand Labrie, Jacques Leclaire, Joan Eilstein, Maria Manso, Pierre-Alain Meunier, Daniel Duche, Jean Pachot, Jean-Roch Meunier

Publikováno v: Toxicology Letters. 180:S90-S91

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a591a35c2ef1483f0d2a008ad5a7798b
https://doi.org/10.1016/j.toxlet.2008.06.480

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