Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jean P. Ouellet"'
Pharmacological Treatment of Degenerative Cervical Myelopathy: A Critical Review of Current Evidence
Autor:
Jordan J Levett, Miltiadis Georgiopoulos, Simon Martel, Wissam Al Mugheiry, Nikolaos A. Stavropoulos, Miguel Vega-Arroyo, Carlo Santaguida, Michael H. Weber, Jeff D. Golan, Peter Jarzem, Jean A. Ouellet, Georgios Klironomos, Andreas K. Demetriades
Publikováno v:
Neurospine, Vol 21, Iss 2, Pp 375-400 (2024)
Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in adults, representing substantial morbidity and significant financial and resource burdens. Typically, patients with progressive DCM will eventually receive surg
Externí odkaz:
https://doaj.org/article/5b0182aa252f408d8ad67150213a7db2
Autor:
Mandy M. J. Li, Don Daniel Ocay, Cynthia L. Larche, Kelsey Vickers, Neil Saran, Jean A. Ouellet, Céline Gélinas, Catherine E. Ferland
Publikováno v:
Canadian Journal of Pain, Vol 7, Iss 1 (2023)
ABSTRACTBackground Postoperative pain cannot be measured accurately among many children with intellectual and developmental disabilities, resulting in underrecognition or delay in recognition of pain. The Critical-Care Pain Observation Tool (CPOT) is
Externí odkaz:
https://doaj.org/article/cb35e2c15dde48a98a05da1e79ae7be3
Autor:
Stephanie Mouchbahani-Constance, Camille Lagard, Justine Schweizer, Isabelle Labonté, Miltiadis Georgiopoulos, Colombe Otis, Manon St-Louis, Eric Troncy, Philippe Sarret, Alfredo Ribeiro-Da-Silva, Jean A. Ouellet, Philippe Séguéla, Marie-Eve Paquet, Reza Sharif-Naeini
Publikováno v:
Neurobiology of Pain, Vol 13, Iss , Pp 100120- (2023)
Despite the high prevalence of chronic pain as a disease in our society, there is a lack of effective treatment options for patients living with this condition. Gene therapies using recombinant AAVs are a direct method to selectively express genes of
Externí odkaz:
https://doaj.org/article/68af778070b643eaa3159c40c84c02f3
Autor:
Ralph J Sakkers, Kathleen Montpetit, Argerie Tsimicalis, Thomas Wirth, Marjolein Verhoef, Reginald Hamdy, Jean A Ouellet, Rene M Castelein, Chantal Damas, Guus J Janus, Wouter H Nijhuis, Leonardo Panzeri, Simona Paveri, Dagmar Mekking, Kelly Thorstad, Richard W Kruse
Publikováno v:
Acta Orthopaedica, Vol 92, Iss 5, Pp 608-614 (2021)
Background and purpose — Involvement of patient organizations is steadily increasing in guidelines for treatment of various diseases and conditions for better care from the patient’s viewpoint and better comparability of outcomes. For this reason
Externí odkaz:
https://doaj.org/article/bce3df7d98e54d798d7eb2d13fc1f625
Autor:
Matthew Mannarino, Oliver Wu-Martinez, Kai Sheng, Li Li, Rodrigo Navarro-Ramirez, Peter Jarzem, Jean A. Ouellet, Hosni Cherif, Lisbet Haglund
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1257 (2023)
Background: Low back pain is a global health problem directly related to intervertebral disc (IVD) degeneration. Senolytic drugs (RG-7112 and o-Vanillin) target and remove senescent cells from IVDs in vitro, improving tissue homeostasis. One drawback
Externí odkaz:
https://doaj.org/article/e21c59e403a94bd093ec2f44b3e728dc
Autor:
Matthew Mannarino, Hosni Cherif, Li Li, Kai Sheng, Oded Rabau, Peter Jarzem, Michael H. Weber, Jean A. Ouellet, Lisbet Haglund
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background There is an increased level of senescent cells and toll-like teceptor-1, -2, -4, and -6 (TLR) expression in degenerating intervertebral discs (IVDs) from back pain patients. However, it is currently not known if the increase in ex
Externí odkaz:
https://doaj.org/article/7e24cf58fd5b4a58b08120a7b9dddf22
Autor:
Maxime St-Georges, Alisson R. Teles, Oded Rabau, Neil Saran, Jean A. Ouellet, Catherine E. Ferland
Publikováno v:
BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Adolescent idiopathic scoliosis (AIS) has been associated with diminished postural stability and a greater prevalence of back pain. Currently, the literature is lacking information on the effect of spinal fusion on both postural s
Externí odkaz:
https://doaj.org/article/88cd9406cd974e059ae1b7bf5562e170
Autor:
Alice Bruneau, Catherine E. Ferland, Rafael Pérez-Medina-Carballo, Marta Somaini, Nada Mohamed, Michele Curatolo, Jean A. Ouellet, Pablo Ingelmo
Publikováno v:
Children, Vol 9, Iss 8, p 1157 (2022)
The evidence supporting the use of pharmacological treatments in pediatric chronic pain is limited. Quantitative sensory testing (QST) and conditioned pain modulation evaluation (CPM) provide information on pain phenotype, which may help clinicians t
Externí odkaz:
https://doaj.org/article/cfffe1d1a84e4bbe86133e2360064b25
Publikováno v:
Ecosphere, Vol 12, Iss 6, Pp n/a-n/a (2021)
Abstract An understanding of habitat use and connectivity is key to preserving wildlife habitat integrity. In this study, we present an innovative approach to habitat connectivity and quantitative assessment of their use that is applicable to any ter
Externí odkaz:
https://doaj.org/article/bd10d4bfbaba4ef2b3688dad68661025
Publikováno v:
eLife, Vol 9 (2020)
Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expressio
Externí odkaz:
https://doaj.org/article/e0bd89ba0da14d62a8909aa653431942