Výsledky vyhledávání - "Jean Olivier Contreres"

Akademický článek

Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma

Autor: Annemilaï Tijeras-Raballand, Patricia Hainaud-Hakim, Jean-Olivier Contreres, Caroline Gest, Carole Le Henaff, Bernard I Levy, Marc Pocard, Claudine Soria, Evelyne Dupuy

Publikováno v: Gastroenterology Research and Practice, Vol 2010 (2010)

Background and Aims. An arterial blood supply and phenotypic changes of the sinusoids characterise the liver vasculature in human hepatocellular carcinoma (HCC). We investigated the effects of rosuvastatin on liver vessel anomalies, tumour growth and

Externí odkaz: https://doaj.org/article/cff483bf9daf4c1cb24376d69f98916d

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Netrin-4 overexpression suppresses primary and metastatic colorectal tumor progression

Autor: Jean-Olivier Contreres, Patricia Hainaud, Evelyne Dupuy, Clarisse Eveno, Marc Pocard, Judith Nemeth

Publikováno v: Oncology Reports. 29:73-78

Tumor angiogenesis is closely associated with clinical staging and has been proposed to correlate with clinical response in terms of subsequent metastases following primary resection. Netrin-4 (NT-4) regulates angiogenic responses. Therefore, we soug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d554102e8bae9bbe290c003647051cf1
https://doi.org/10.3892/or.2012.2104

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Ephrin-B2–Activated Peripheral Blood Mononuclear Cells From Diabetic Patients Restore Diabetes-Induced Impairment of Postischemic Neovascularization

Autor: Jean-Olivier Contreres, Yu Wang, Jean-Sébastien Silvestre, Chris S. Mantsounga, Tatiana Merkulova-Rainon, Marie Virally, Pierre-Jean Guillausseau, Jean-Jacques Mourad, Bernard I. Levy, Carole Leré-Déan, David Allanic, Patricia Hainaud, Dong Broqueres-You, José Vilar

Publikováno v: Diabetes

We hypothesized that in vitro treatment of peripheral blood mononuclear cells (PB-MNCs) from diabetic patients with ephrin-B2/Fc (EFNB2) improves their proangiogenic therapeutic potential in diabetic ischemic experimental models. Diabetes was induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2138d67be125257cd7212f45616da5
http://europepmc.org/articles/PMC3447889

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Abstract 2043: PlGF/VEGFR-1-dependent activation of Dll4/Notch4 pathway contributes to liver vessel abnormalities and tumor growth in hepatocellular carcinoma

Autor: Evelyne Dupuy, Philippe Bonnin, Patricia Hainaud, C. Hobeika, Matthieu Martinet, Clarisse Eveno, Eric Raymond, Annemilaï Tijeras-Raballand, Sandrine Faivre, Armand de Gramont, Jean-Olivier Contreres, Marc Pocard, Valérie Paradis

Publikováno v: Cancer Research. 78:2043-2043

Background: Hepatocellular carcinoma (HCC) is characterized by strong abnormalities of liver vasculature linked to proangiogenic pathways in the tumor and its microenvironment. Upregulation of Notch4 and its ligand Dll4 in endothelial cells (ECs), as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e7d0040966af9bfa01b9a6d0118bdcf
https://doi.org/10.1158/1538-7445.am2018-2043

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Angiotensinogen Delays Angiogenesis and Tumor Growth of Hepatocarcinoma in Transgenic Mice

Autor: Philippe Bonnin, Evelyne Dupuy, Noël Lamandé, Jean-Marie Gasc, Patricia Hainaud, François Vincent, Maud Clemessy, Pierre Corvol, José Vilar, Gérard Tobelem, Jean-Olivier Contreres

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2009, 69 (7), pp.2853-60. ⟨10.1158/0008-5472.CAN-08-2484⟩

Angiotensinogen, a member of the serpin family, is involved in the suppression of tumor growth and metastasis. To investigate whether human angiotensinogen protects against tumor progression in vivo, we established an original bitransgenic model in w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845a743e60b30c6ae261424929545b04
https://doi.org/10.1158/0008-5472.can-08-2484

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Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms

Autor: Jean-Olivier Contreres, Marijke Bryckaert, Gérard Tobelem, Julie Lacour, Eric Sulpice

Publikováno v: European Journal of Biochemistry. 271:3310-3318

The mechanism by which the CXC chemokine platelet factor 4 (PF-4) inhibits endothelial cell proliferation is unclear. The heparin-binding domains of PF-4 have been reported to prevent vascular endothelial growth factor 165 (VEGF165) and fibroblast gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6bea4f02d004967bb3b5640f76188ff
https://doi.org/10.1111/j.1432-1033.2004.04263.x

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Ex vivo differentiated endothelial and smooth muscle cells from human cord blood progenitors home to the angiogenic tumor vasculature

Autor: Jean-Olivier Contreres, Bernadette Boval, Gérard Tobelem, Véronique Barateau, Laurence Kraus-Berthier, Sophie Le Ricousse-Roussanne

Publikováno v: Cardiovascular Research. 62:176-184

Objectives: Recent studies have provided increasing evidence that postnatal neovascularization does not rely exclusively on sprouting of preexisting vessels, but also involves bone marrow-derived circulating endothelial precursors (BM-EPCs). Animal s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aee9cf0fb14dfeeaefa7c8c42062674
https://doi.org/10.1016/j.cardiores.2004.01.017

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Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP

Autor: Evelyne Dupuy, Jean Rosa, Sylviane Levy-Toledano, Guy Simoneau, Aida Habib, Marg̈ke Bryckaert, Jean Olivier Contreres, Bernard Job, Jean Marc Herbert, Pierre Savi

Publikováno v: British Journal of Haematology. 120:633-642

Summary. The action of clopidogrel on platelet receptors was analysed using platelets obtained from 11 healthy volunteers given 75 mg of clopidogrel daily for 8 d. Samples of blood were taken before treatment and after 8 d of medication. Determinatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f41f2570ce1a6267cca0c0c37606c6bc
https://doi.org/10.1046/j.1365-2141.2003.04166.x

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Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal–regulated kinase pathway but not by the phosphatidylinositol 3–kinase pathway

Autor: Jean-Olivier Contreres, Marijke Bryckaert, Gérard Tobelem, Eric Sulpice, Julie Lacour

Publikováno v: Blood. 100:3087-3094

Platelet factor 4 (PF-4) is a member of the chemokine family with powerful antiangiogenic properties. The mechanism by which PF-4 inhibits endothelial cell proliferation is unclear. We investigated the effects of PF-4 on the intracellular signal tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22b101df33283e32085ce49ad0f0e37
https://doi.org/10.1182/blood.v100.9.3087

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Proof of prometastatic niche induction by hepatic stellate cells

Autor: Clarisse Eveno, Philippe Bonnin, Patricia Hainaud, Evelyne Dupuy, Sana Bakhouche, Jean-Olivier Contreres, Marc Pocard, Aurore Rampanou

Publikováno v: The Journal of surgical research. 194(2)

Background An interaction between tumor cells and the microenvironment, as well as the development of angiogenesis, are required to form liver metastases (LMs). Material and methods Immunofluorescence detection of α-smooth muscle actin, desmin, Ki67

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3366023b44afbc8fc14b919cf790273
https://pubmed.ncbi.nlm.nih.gov/25528682

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