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Autor:
Shudong Wang, Jiri Klinot, Vera Noskova, Simon Parsons, V. Krecek, Jan Sarek, Nikolai Zhelev, Eva Klinotová, Peter Fischer, Jean Oliver Thomson, Gabriela Korinkova, Petr Dzubak, Marian Hajduch, Anna Janostakova
Publikováno v:
Journal of Medicinal Chemistry. 46:5402-5415
Cellular screening of various synthetic triterpenoid compounds formally derived from lupane has identified a number of analogues as potential anticancer drug candidates. Here we describe the synthesis and structure-activity relationships of betulin a