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Akademický článek

Role of peripheral blood MRD and 18F-FDG PET in the post-CAR relapse setting: a case study of discordant peripheral blood and bone marrow MRD

Autor: Crystal L Mackall, Christina Baggott, Kara Lynn Davis, Liora Schultz, Ann Walkush, Courtney Erickson, Sneha Ramakrishna, Catherine Aftandilian, Norman Lacayo, Helen Ruth Nadel, Jean Oak

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)

Background: Chimeric antigen receptor (CAR) T cell therapy is an effective salvage therapy for pediatric relapsed B-cell acute lymphoblastic leukemia (B-ALL), yet is challenged by high rates of post-CAR relapse. Literature describing specific relapse

Externí odkaz: https://doaj.org/article/0898e66bc0de4d3099ca0993cfc0cfe9

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Akademický článek

Detection of cryptogenic malignancies from metagenomic whole genome sequencing of body fluids

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-11 (2021)

Abstract Background Metagenomic next-generation sequencing (mNGS) of body fluids is an emerging approach to identify occult pathogens in undiagnosed patients. We hypothesized that metagenomic testing can be simultaneously used to detect malignant neo

Externí odkaz: https://doaj.org/article/03436cd749174bfe8eee0110b5e5db0b

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Akademický článek

Identification of dual positive CD19+/CD3+ T cells in a leukapheresis product undergoing CAR transduction: a case report

Autor: Crystal Mackall, Alice Bertaina, Steven Feldman, Christina Baggott, Bita Sahaf, Kara Lynn Davis, Liora Schultz, Courtney Erickson, Sneha Ramakrishna, Jean Oak, Robbie G Majzner, Shabnum Patel, Neehar Bhatia

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Chimeric antigen receptor (CAR) therapy and hematopoietic stem cell transplantation (HSCT) are therapeutics for relapsed acute lymphocytic leukemia (ALL) that are increasingly being used in tandem. We identified a non-physiologic CD19+/CD3

Externí odkaz: https://doaj.org/article/655f1d8061314500801f36eba62481ed

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Targeted Mutational Profiling Reveals Clonal Relationships in Metachronous Occurrence of Classic Hodgkin and Mediastinal Large B-Cell Lymphomas

Autor: Kunwar Singh, Lhara S. Lezama, Jason Kurzer, Jean Oak, Liora M. Schultz, Ann Walkush, Tse-Chang Cheng, Everett H. Chen, William A. May, Cheryl Chang, Michael P. Link, Ranjana H. Advani, Carlos J. Suarez, Yasodha Natkunam

Publikováno v: American Journal of Surgical Pathology. 47:81-90

Classic Hodgkin lymphoma (CHL) patients may infrequently present with a prior or recurrent disease with discordant histology resembling non-Hodgkin lymphomas. These include primary mediastinal large B-cell lymphoma (PMBL), diffuse large B-cell lympho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e531f31e7e0c2ac41fe966d2724e2e9
https://doi.org/10.1097/pas.0000000000001956

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A cell-level discriminative neural network model for diagnosis of blood cancers

Autor: Edgar E. Robles, Ye Jin, Padhraic Smyth, Richard H. Scheuermann, Jack D. Bui, Huan-You Wang, Jean Oak, Yu Qian

Publikováno v: medRxiv

MotivationPrecise identification of cancer cells in patient samples is essential for accurate diagnosis and clinical monitoring but has been a significant challenge in machine learning approaches for cancer precision medicine. In most scenarios, trai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3e07602ba425efe84eb66b074f22f9
https://europepmc.org/articles/PMC9934808/

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Machine Learning Predictability of Clinical Next Generation Sequencing for Hematologic Malignancies to Guide High-Value Precision Medicine

Autor: Grace Y E, Kim, Morteza, Noshad, Henning, Stehr, Rebecca, Rojansky, Dita, Gratzinger, Jean, Oak, Rondeep, Brar, David, Iberri, Christina, Kong, James, Zehnder, Jonathan H, Chen

Publikováno v: AMIA Annu Symp Proc

Advancing diagnostic testing capabilities such as clinical next generation sequencing methods offer the potential to diagnose, risk stratify, and guide specialized treatment, but must be balanced against the escalating costs of healthcare to identify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ebcb356642963cbcb13840b0d97d5b6
https://pubmed.ncbi.nlm.nih.gov/35308914

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Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3 SH2 Domain Mutations

Autor: Jean Oak, Michael S. Khodadoust, Sebastian Fernandez-Pol, Kerri E. Rieger, Bruce Petersen, Jo-Ellen Murphy, Erica B.K. Wang, Youn H. Kim, Carlos Suárez

Publikováno v: American Journal of Surgical Pathology. 45:193-199

Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6764af18106273b52978d5e97092e832
https://doi.org/10.1097/pas.0000000000001604

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Histology-Independent Signature Distinguishes Kikuchi-Fujimoto Disease/Systemic Lupus Erythematosus–Associated Lymphadenitis From Benign and Malignant Lymphadenopathies

Autor: Philipp W. Raess, Dita Gratzinger, Jyoti Kumar, Jean Oak, Scott D. Boyd, Gregory D. Scott

Publikováno v: American Journal of Clinical Pathology. 154:215-224

Objectives Kikuchi-Fujimoto disease (KFD) and systemic lupus erythematosus (SLE) are benign entities with histologic features that raise concern about malignancy and infection. We searched for a histology-independent KFD/SLE signature relying on only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8948924f261b0bc15f55ee2b75f9e371
https://doi.org/10.1093/ajcp/aqaa036

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