Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jean Nicolas Schickel"'
Autor:
Jeff W. Chen, Jean-Nicolas Schickel, Nikolaos Tsakiris, Joel Sng, Florent Arbogast, Delphine Bouis, Daniele Parisi, Ruchi Gera, Joshua M. Boeckers, Fabien R. Delmotte, Margaret Veselits, Catharina Schuetz, Eva-Maria Jacobsen, Carsten Posovszky, Ansgar S. Schulz, Klaus Schwarz, Marcus R. Clark, Laurence Menard, Eric Meffre
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of
Externí odkaz:
https://doaj.org/article/e5d69aac33524de49d493bed037a80ad
Autor:
Nina K. Serwas, Birgit Hoeger, Rico C. Ardy, Sigrun V. Stulz, Zhenhua Sui, Nima Memaran, Marie Meeths, Ana Krolo, Özlem Yüce Petronczki, Laurène Pfajfer, Tie Z. Hou, Neil Halliday, Elisangela Santos-Valente, Artem Kalinichenko, Alan Kennedy, Emily M. Mace, Malini Mukherjee, Bianca Tesi, Anna Schrempf, Winfried F. Pickl, Joanna I. Loizou, Renate Kain, Bettina Bidmon-Fliegenschnee, Jean-Nicolas Schickel, Salomé Glauzy, Jakob Huemer, Wojciech Garncarz, Elisabeth Salzer, Iro Pierides, Ivan Bilic, Jens Thiel, Peter Priftakis, Pinaki P. Banerjee, Elisabeth Förster-Waldl, David Medgyesi, Wolf-Dietrich Huber, Jordan S. Orange, Eric Meffre, David M. Sansom, Yenan T. Bryceson, Amnon Altman, Kaan Boztug
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
CTLA-4 is critical for balancing protective immunity with self-tolerance. Here the authors identify homozygous DEF6 mutations in patients with severe autoimmunity, one of which received and responds to CTLA-4-Ig, and show that DEF6 is crucial for CTL
Externí odkaz:
https://doaj.org/article/2b28c1d1ae924d86a02c99db5aac2d80
Autor:
Nina K. Serwas, Birgit Hoeger, Rico C. Ardy, Sigrun V. Stulz, Zhenhua Sui, Nima Memaran, Marie Meeths, Ana Krolo, Özlem Yüce Petronczki, Laurène Pfajfer, Tie Z. Hou, Neil Halliday, Elisangela Santos-Valente, Artem Kalinichenko, Alan Kennedy, Emily M. Mace, Malini Mukherjee, Bianca Tesi, Anna Schrempf, Winfried F. Pickl, Joanna I. Loizou, Renate Kain, Bettina Bidmon-Fliegenschnee, Jean-Nicolas Schickel, Salomé Glauzy, Jakob Huemer, Wojciech Garncarz, Elisabeth Salzer, Iro Pierides, Ivan Bilic, Jens Thiel, Peter Priftakis, Pinaki P. Banerjee, Elisabeth Förster-Waldl, David Medgyesi, Wolf-Dietrich Huber, Jordan S. Orange, Eric Meffre, David M. Sansom, Yenan T. Bryceson, Amnon Altman, Kaan Boztug
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2ad5e2b7ab8840e49f562084ad81cfe1
Autor:
Jean‐Nicolas Schickel, Jean‐Louis Pasquali, Anne Soley, Anne‐Marie Knapp, Marion Decossas, Aurélie Kern, Jean‐Daniel Fauny, Luc Marcellin, Anne‐Sophie Korganow, Thierry Martin, Pauline Soulas‐Sprauel
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 12, Pp 1261-1275 (2012)
Abstract The mechanisms behind flares of human autoimmune diseases in general, and of systemic lupus in particular, are poorly understood. The present scenario proposes that predisposing gene defects favour clinical flares under the influence of exte
Externí odkaz:
https://doaj.org/article/79f702fee8f448459736bfe5bed5e3a0
Autor:
Daniele Parisi, Florent Arbogast, Nikolaos Tsakiris, Fabien R. Delmotte, Jean-Nicolas Schickel, Delphine Bouis, Catharina Schuetz, Laurence Menard, Marcus R. Clark, Carsten Posovszky, Ruchi Gera, Eva-Maria Jacobsen, Joshua M Boeckers, Klaus Schwarz, Margaret Veselits, Jeff W. Chen, Ansgar Schulz, Joel Sng, Eric Meffre
Publikováno v:
The Journal of Clinical Investigation
Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d92c0896d86d9b5682d8ed28628cb5e
https://pubmed.ncbi.nlm.nih.gov/34813502
https://pubmed.ncbi.nlm.nih.gov/34813502
Autor:
Jean-Claude Garaud, Jean-Nicolas Schickel, Gilles Blaison, Anne-Marie Knapp, Doulaye Dembele, Julie Ruer-Laventie, Anne-Sophie Korganow, Thierry Martin, Pauline Soulas-Sprauel, Jean-Louis Pasquali
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23900 (2011)
Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies
Externí odkaz:
https://doaj.org/article/5df10ee521d74432b3708ce21b5fdc0b
Autor:
Jean-Laurent Casanova, Capucine Picard, Christopher Massad, Nicolas Chamberlain, Isabelle Isnardi, Steven M. Holland, Gulbu Uzel, Yen Shing Ng, Nathan Katz, Salomé Glauzy, Eric Meffre, Anne Puel, Jean-Nicolas Schickel
Publikováno v:
The Journal of Experimental Medicine
The human VH4-34 gene segment encodes intrinsically self-reactive antibodies that recognize I/i carbohydrates. Schickel et al. show that these self-reactive clones may represent an innate-like B cell population specialized in the containment of comme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13ae487e110826d3bd967a0410b1091
https://doi.org/10.1084/jem.20160201
https://doi.org/10.1084/jem.20160201
Autor:
Shu Zhu, Elizabeth E. Eynon, Chiara Borsotti, George D. Yancopoulos, Till Strowig, Cagan Gurer, Andrew J. Murphy, Markus G. Manz, Richard A. Flavell, Davor Frleta, Jean-Nicolas Schickel, Eric Meffre, Hua Yu
Publikováno v:
Blood. 129:959-969
Humanized mice are a powerful tool for the study of human hematopoiesis and immune function in vivo. However, the existing models cannot support robust adaptive immune responses, especially the generation of class-switched, antigen-specific antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17e369dd307aa53246ca959ff5c98f6
https://doi.org/10.1182/blood-2016-04-709584
https://doi.org/10.1182/blood-2016-04-709584
Autor:
Jeff W. Chen, Andrea Vega-Loza, Eric Meffre, Natsuko Yamakawa, Kofi A. Mensah, Jennifer H. Anolik, Ruth R. Montgomery, Jean-Nicolas Schickel, Erwin W. Gelfand, Mark C. Horowitz, Joe Craft, Isabelle Isnardi, Richard A. Gatti
Publikováno v:
Sci Transl Med
Patients with rheumatoid arthritis (RA) may display atypical CD21-/lo B cells in their blood, but the implication of this observation remains unclear. We report here that the group of patients with RA and elevated frequencies of CD21-/lo B cells show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ba4e4cc574fbd12160489fc13f3fd7
https://europepmc.org/articles/PMC7167286/
https://europepmc.org/articles/PMC7167286/
Autor:
Michael Haugwitz, orell M, May Ap, el Gaudio D, Paige Krystofinski, Lee Mr, Amy L. Putnam, Gorka Alkorta-Aranburu, Theodore L. Roth, Li Pj, Eric Meffre, Julia Carnevale, Laurence Pellerin, Greeley Saw, Maria Grazia Roncarolo, David Carmody, David N. Nguyen, Leonetti, Mao Y, Channabasavaiah B. Gurumurthy, Justin Saco, shworth A, Cristina Puig-Saus, Alexander Marson, Cho M, Rolen M. Quadros, Eric Shifrut, Rosa Bacchetta, Kevan C. Herold, Hiatt, Tobin, Jean-Nicolas Schickel, Jonathan S. Weissman, Chen Jw, Yu R, Jonathan H. Esensten, Antoni Ribas, Andrea L. Ferris, Neil Romberg, Matsumoto H, Kathrin Schumann, Gary M. Kupfer, Baz Smith, Hang Li, Stephen H. Hughes
Publikováno v:
Yearbook of Paediatric Endocrinology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2410db72455f059074d2ce408ec2ba64
https://doi.org/10.1530/ey.16.14.4
https://doi.org/10.1530/ey.16.14.4