Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Jean Michel Vernes"'
1
Akademický článek
Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response
Autor: Deepak Sampath, Jason Oeh, Shelby K. Wyatt, Tim C. Cao, Hartmut Koeppen, Jeffrey Eastham-Anderson, Liliane Robillard, Calvin C.K. Ho, Jed Ross, Guanglei Zhuang, Hani Bou Reslan, Philip Vitorino, Kai H. Barck, Sharon E. Ungersma, Jean Michel Vernes, Maresa Caunt, Nick Van Bruggen, Weilan Ye, Ulka Vijapurkar, Yu-Ju Gloria Meng, Napoleone Ferrara, Lori S. Friedman, Richard A.D. Carano
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 694-711 (2013)
The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin
Externí odkaz: https://doaj.org/article/d0983e4f9813439184cf3adfb4b7c460
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2
Akademický článek
Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics
Autor: Daniela Bumbaca Yadav, Arthur E. Reyes II, Priyanka Gupta, Jean‐Michel Vernes, Y. Gloria Meng, Michelle G. Schweiger, Shannon L. Stainton, Germaine Fuh, Paul J. Fielder, Amrita V. Kamath, Ben‐Quan Shen
Publikováno v: Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract A phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma. The purpose of thi
Externí odkaz: https://doaj.org/article/a2642f34ca374b879cf1e05fa87c259f
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3
Akademický článek
A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies
Autor: Rajesh Vij, Zhonghua Lin, Nancy Chiang, Jean-Michel Vernes, Kelly M. Storek, Summer Park, Joyce Chan, Y. Gloria Meng, Laetitia Comps-Agrar, Peng Luan, Sophia Lee, Kellen Schneider, Jack Bevers, Inna Zilberleyb, Christine Tam, Christopher M. Koth, Min Xu, Avinash Gill, Marcy R. Auerbach, Peter A. Smith, Steven T. Rutherford, Gerald Nakamura, Dhaya Seshasayee, Jian Payandeh, James T. Koerber
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β-barrel assembly machinery a
Externí odkaz: https://doaj.org/article/987be71cec3148fcbac3acf988d53af6
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4
Akademický článek
Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD
Autor: Kelly M Storek, Joyce Chan, Rajesh Vij, Nancy Chiang, Zhonghua Lin, Jack Bevers III, Christopher M Koth, Jean-Michel Vernes, Y Gloria Meng, JianPing Yin, Heidi Wallweber, Olivier Dalmas, Stephanie Shriver, Christine Tam, Kellen Schneider, Dhaya Seshasayee, Gerald Nakamura, Peter A Smith, Jian Payandeh, James T Koerber, Laetitia Comps-Agrar, Steven T Rutherford
Publikováno v: eLife, Vol 8 (2019)
Outer membrane proteins (OMPs) in Gram-negative bacteria dictate permeability of metabolites, antibiotics, and toxins. Elucidating the structure-function relationships governing OMPs within native membrane environments remains challenging. We constru
Externí odkaz: https://doaj.org/article/ce2cff4a5d574858abb6291276ed9aec
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