Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jean Michel Poul"'
Autor:
Fanny Héraud, Tristan Lorino, Nawel Bemrah, Jean-Michel Poul, Jean Marc Frémy, Françoise Gauchard, Claude Lambré, Mostafa Ould Elhkim
Publikováno v:
Regulatory Toxicology and Pharmacology. 47:308-316
Tartrazine is an artificial azo dye commonly used in human food and pharmaceutical products. Since the last assessment carried out by the JECFA in 1964, many new studies have been conducted, some of which have incriminated tartrazine in food intolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07f7f96c32eadf391060648b7ed6816
https://doi.org/10.1016/j.yrtph.2006.11.004
https://doi.org/10.1016/j.yrtph.2006.11.004
Publikováno v:
Environmental Toxicology. 19:123-128
Okadaic acid (OA), a major polyether toxin involved in diarrhetic shellfish poisoning (DSP), is a potent tumor promoter in rodent skin and glandular stomach and a specific inhibitor of the serine/threonine protein phosphatases PP1 and PP2A. A previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead0a7dea09a7a2564dd20a660b223ae
https://doi.org/10.1002/tox.20004
https://doi.org/10.1002/tox.20004
Publikováno v:
Journal of Applied Toxicology. 23:59-70
This study investigates the kinetics of bone marrow micronucleated polychromatic erythrocytes and some mechanistic aspects of micronuclei induction using mathematical models. Female mice were administered a single intraperitoneal injection of the pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b3e8d50c5e91f7f25a7b6a03185276
https://doi.org/10.1002/jat.888
https://doi.org/10.1002/jat.888
Publikováno v:
Regulatory Toxicology and Pharmacology. 34:125-136
In order to evaluate an in vivo model system for assessing the effect of therapeutic and residue levels of tetracycline on human intestinal microflora, tetracycline was administered via drinking water (1, 10, and 100 mg/liter) to human-flora-associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a4819bfc9c6e34f49029c7491cf6be
https://doi.org/10.1006/rtph.2001.1495
https://doi.org/10.1006/rtph.2001.1495
Autor:
Karine Labay, Mostafa Ould-Elhkim, Virginie Klés, Pascal Sanders, Magali Guffroy, Jean-Michel Poul
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 21:441-451
Published data have suggested a possible link between the tumor promoting activity and the aneugenic properties of griseofulvin. The present study was conducted to explore this relationship. Griseofulvin was evaluated both for its potential promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b142fc91443b205fecadcf01254fc49b
https://doi.org/10.1002/tcm.1031
https://doi.org/10.1002/tcm.1031
Publikováno v:
Journal of Applied Toxicology. 19:421-430
The genotoxic potential of the fungicide malachite green (MG) and its reduced derivative leucomalachite green (LMG) was assessed in bacteria and mammalian cells using the standard Salmonella typhimurium/Ames and CHO/HGPRT tests. In vitro potential DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d72b023b48457f5cf774c5c875c2254
https://doi.org/10.1002/(sici)1099-1263(199911/12)19:6<421::aid-jat595>3.0.co
https://doi.org/10.1002/(sici)1099-1263(199911/12)19:6<421::aid-jat595>3.0.co
Autor:
T. Godard, Edwige Deslandes, Jean-Michel Poul, François Sichel, Pascal Gauduchon, C. Vigreux, Pierre Lebailly
Publikováno v:
Histochemistry and Cell Biology. 112:155-161
Comet, TUNEL, and annexin V assays were used to identify DNA fragmentation and plasma membrane alterations occurring during staurosporine-induced apoptosis in Chinese hamster ovary cells. TUNEL assay detected apoptotic cells after 6 h treatment. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81305e8b12223f1ff049a0a9be5a132
https://doi.org/10.1007/s004180050402
https://doi.org/10.1007/s004180050402
Autor:
Jean-Michel Poul, François Sichel, Annick Mourot, Edwige Deslandes, Ollivier Hyrien, Pascal Gauduchon, Valérie Fessard, Thierry Godard, Didier Pottier, Sylvie Huet
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 444:103-116
The alkaline single cell gel electrophoresis (comet) assay was used to assess in vitro and in vivo genotoxicity of etoposide, a topoisomerase II inhibitor known to induce DNA strand breaks, and chlorothalonil, a fungicide widely used in agriculture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee53172d51197efff1afaab749ba918d
https://doi.org/10.1016/s1383-5718(99)00100-x
https://doi.org/10.1016/s1383-5718(99)00100-x
Autor:
Pascal Gauduchon, Pierre Lebailly, Edwige Deslandes, Thierry Godard, François Sichel, Laurent Poulain, Carole Vigreux, Jean-Michel Poul
Publikováno v:
Cytometry. 36:117-122
Background: The ability of the comet assay to quantify DNA strand breaks and alkali labile sites has been widely demonstrated. In this study, this assay was tested for its ability to identify DNA fragmentation occurring during apoptosis in comparison
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9604b7b3ca0b0a7fdea7dcaf09752e0f
https://doi.org/10.1002/(sici)1097-0320(19990601)36:2<117::aid-cyto5>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19990601)36:2<117::aid-cyto5>3.0.co
Autor:
Pierre Lebailly, Edwige Deslandes, Jean-Michel Poul, François Sichel, Carole Vigreux, Thierry Godard, Michel Henry-Amar, Pascal Gauduchon
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 419:79-90
One herbicide (isoproturon), two fungicides (carbendazim and chlorothalonil) and etoposide (an effective antitumor agent used as a positive control), were tested for their ability to induce cytotoxic and genotoxic effects in Chinese Hamster Ovary (CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e32a478e42f37190cebaa83b535129
https://doi.org/10.1016/s1383-5718(98)00126-0
https://doi.org/10.1016/s1383-5718(98)00126-0