Výsledky vyhledávání - "Jean Michel H. Vos"

Development of a Competitive PCR Method for Physical Titration of Recombinant EBV Vector in a Helper-Dependent Packaging System

Autor: Jianlong Wang, Jean-Michel H. Vos

Publikováno v: Molecular Therapy. 3:976-983

Epstein–Barr virus (EBV) is a γ-herpesvirus with B lymphotropism and a double-stranded DNA genome of 172 kb that is episomally maintained in permissive cells during latency. EBV-based vectors containing minimal cis elements for replication, amplif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43819bdab04ac18b8f323a509aacc1a7
https://doi.org/10.1006/mthe.2001.0326

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Epstein-Barr–based episomal chromosomes shuttle 100 kb of self-replicating circular human DNA in mouse cells

Autor: Brian J. Wendelburg, Elizabeth Livanos, Sara Gulino, Zachary T. Kelleher, Jean-Michel H. Vos, Haiyan Fu

Publikováno v: Nature Biotechnology. 16:762-768

We describe the microcell fusion transfer of 100–200 kb self-replicating circular human minichromosomes from human into mouse cells. This experimental approach is illustrated through the shuttling of the latent 170 kb double-stranded DNA genome fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9751d6772fb0d7c08c50ddde1111e83b
https://doi.org/10.1038/nbt0898-762

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Defective replication of psoralen adducts detected at the gene-specific level in xeroderma pigmentosum variant cells

Autor: Jean-Michel H. Vos, R. Rita Misra

Publikováno v: Molecular and Cellular Biology. 13:1002-1012

Replication of damaged DNA is suspected to play an important role in cell cycle, genetic stability, and survival pathways. Using psoralen photoaddition as prototype DNA damage and the renaturing agarose gel electrophoresis technique to measure DNA cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161128dbd40b66a090a1be0779142088
https://doi.org/10.1128/mcb.13.2.1002

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Cis and trans mechanisms of DNA repair

Autor: Jean-Michel H. Vos

Publikováno v: Current Opinion in Cell Biology. 4:385-395

DNA repair is essential for genetic stability and variability. Remarkable advances in the understanding of DNA repair by the molecular analysis of the substrate (gene repair) or the enzyme (repair genes), emphasize evolutionary conservation. Recent p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f86c6ad2f70ab4d81f59039c14be3f
https://doi.org/10.1016/0955-0674(92)90003-u

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Differential introduction of DNA damage and repair in mammalian genes transcribed by RNA polymerases I and II

Autor: E. L. Wauthier, Jean-Michel H. Vos

Publikováno v: Molecular and Cellular Biology. 11:2245-2252

We have developed a general quantitative method for comparing the levels of drug-induced DNA crosslinking in specific mammalian genes. We observed a dramatic difference between the efficiency of the removal of both psoralen monoadducts and interstran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7631cc9488b040100ccfd44622013fda
https://doi.org/10.1128/mcb.11.4.2245

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Differential repair and replication of damaged DNA in ribosomal RNA genes in different CHO cell lines

Autor: Philip C. Hanawalt, Jean-Michel H. Vos, Eliane Wauthier

Publikováno v: Journal of Cellular Biochemistry. 43:173-183

We studied the repair of psoralen adducts in the pol I-transcribed ribosomal RNA (rRNA) genes of excision repair competent Chinese hamster ovary (CHO) cell lines, their UV sensitive mutant derivatives, and their UV resistant transformants, which expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae572d3765c9dd79b13146d0358bdc01
https://doi.org/10.1002/jcb.240430208

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The simplicity of complex MACs

Autor: Jean-Michel H. Vos

Publikováno v: Nature Biotechnology. 15:1257-1259

The development of mammalian artificial chromosomes (MACs) would be useful for biotechnology and biomedicine, including their use in functional genomics, transgenic animals and gene therapy. By analogy to large cloning systems in microorganisms, MACs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455fc9b6567d24d372a66255cbdbb04a
https://doi.org/10.1038/nbt1197-1257

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