Výsledky vyhledávání - "Jean Michel Goust"

The Effects of Calpain Inhibition on IkBα Degradation After Activation of PBMCs: Identification of the Calpain Cleavage Sites

Autor: Jean-Michel Goust, Naren L. Banik, Kurt E. Schaecher

Publikováno v: Neurochemical Research. 29:1443-1451

Human peripheral blood mononuclear cells (PBMCs) were activated using anti-CD3/CD28 (HIT3A/CD28.2) resulting in degradation of IkB alpha, an inhibitor of NFkB, relative to unactivated cells. Degradation of IkB alpha began by 30 min and proceeded for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fea1dce1bcb268efb912a62d7de7a19
https://doi.org/10.1023/b:nere.0000026410.56000.dd

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Calpain activity and expression are increased in splenic inflammatory cells associated with experimental allergic encephalomyelitis

Autor: Donald C. Shields, Jean-Michel Goust, Naren L. Banik, Kurt E. Schaecher

Publikováno v: Journal of Neuroimmunology. 99:1-12

Since calcium-activated neutral proteinase (calpain) activity and expression are significantly increased in activated glial/inflammatory cells in the central nervous system of animals with autoimmune demyelinating diseases, this enzyme may also play

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaff896768014d204371d9978c471fd4
https://doi.org/10.1016/s0165-5728(99)00043-0

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Effects of calpain inhibition on IkBα degradation following PBMC activation: identification of calpain cleavage sites

Autor: Jean-Michel Goust, Naren L. Banik, Kurt E. Schaecher, A. Rocchini

Publikováno v: Journal of Neurochemistry. 81:54-56

We previously demonstrated calpain-mediated activation of PBMCs. In order to examine whether calpain plays a role in the degradation of IkBα and NFkβ translocation in the mechanism of T cell activation, human PBMCs were activated using anti-CD3/CD2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9be246cf71a52902d22d505febac5ab
https://doi.org/10.1046/j.1471-4159.81.s1.18_6.x

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Calpain Expression in Lymphoid Cells

Autor: Jean-Michel Goust, Naren L. Banik, Edward L. Hogan, Ernest Barbosa, Rajendra V. Deshpande, Arun K. Chakrabarti

Publikováno v: Journal of Biological Chemistry. 270:2497-2505

Although calpain is ubiquitously present in human tissues and is thought to play a role in demyelination, its activity is very low in resting normal lymphocytes. To determine the nature of calpain expression at the mRNA and protein levels in human ly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74ab43985a81487daffab398642ddd9a
https://doi.org/10.1074/jbc.270.6.2497

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