Zobrazeno 1 - 2
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pro vyhledávání: '"Jean McLarty"'
Publikováno v:
Biotechnology and Bioengineering. 116:320-332
In this study, we investigated the effects of alternating tangential flow (ATF) cell separation on high-density perfusion cultures. We have developed methods to estimate theoretical residence times of cells in the ATF system and discovered that long
Autor:
Chris Hwang, Jason Walther, Jiuyi Lu, Jean McLarty, Myles Hollenbach, Kevin Brower, Marcella Yu
Publikováno v:
Biotechnology journal. 14(2)
In this study, the authors compared the impacts of fed-batch and perfusion platforms on process and product attributes for IgG1- and IgG4-producing cell lines. A "plug-and-play" approach is applied to both platforms at bench scale, using commercially