Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Jean Marie Wurtz"'
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Molecular Basis for the Antiparasitic Activity of a Mercaptoacetamide Derivative That Inhibits Histone Deacetylase 8 (HDAC8) from the Human Pathogen Schistosoma mansoni
Autor: Raymond J. Pierce, Tobias Rumpf, Jelena Melesina, Alexander-Thomas Hauser, Diana A. Stolfa, Emeline Leproult, Julien Lancelot, Jean-Marie Wurtz, Wolfgang Sippl, Alexandra Walter, Jean Cavarelli, Christophe Romier, Manfred Jung, Martin Marek
Publikováno v: Journal of Molecular Biology. 426(20):3442-3453
Schistosomiasis, caused by the parasitic flatworm Schistosoma mansoni and related species, is a tropical disease that affects over 200 million people worldwide. A new approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38f6fa0f77fdeb9f92f85922b39d1e1
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2
Akademický článek
Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands
Autor: Souphatta Sasorith, Isabelle M.L. Billas, Thomas Iwema, Dino Moras, Jean-Marie Wurtz
Publikováno v: Journal of Insect Science, Vol 2, p 25 (2002)
The ultraspiracle protein (USP) is the insect ortholog of the mammalian retinoid X receptor (RXR). Fundamental questions concern the functional role of USP as the heterodimerization partner of insect nuclear receptors such as the ecdysone receptor. T
Externí odkaz: https://doaj.org/article/19c5227824dc4a14a913d8acd7af0ffc
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4
Histone H3 Tails Containing Dimethylated Lysine and Adjacent Phosphorylated Serine Modifications Adopt a Specific Conformation during Mitosis and Meiosis
Autor: Lourdes Ponce-Perez, Cédric Grauffel, Sarah Kimmins, Romain Lambrot, Laszlo Tora, Annick Dejaegere, Flavie Robert, Danièle Spehner, Maria-Elena Torres-Padilla, Roland H. Stote, Jean-Marie Wurtz, Adrien Eberlin, Mustapha Oulad-Abdelghani, Patrick Schultz
Publikováno v: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2008, 28 (5), pp.1739-54. ⟨10.1128/MCB.01180-07⟩
Condensation of chromatin, mediated in part by posttranslational modifications of histones, is essential for cell division during mitosis. Histone H3 tails are dimethylated on lysine (Kme2) and become phosphorylated on serine (Sp) residues during mit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2287df8955a24eb2ac4a4f2e3a1ffa
https://doi.org/10.1128/mcb.01180-07
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5
Critical Role of Desolvation in the Binding of 20-Hydroxyecdysone to the Ecdysone Receptor
Autor: Jean-Marie Wurtz, Elyette Martin, Caroline Loch, Dino Moras, Roland H. Stote, Christopher Browning, Annick Dejaegere, Isabelle M. L. Billas
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (45), pp.32924-32934. ⟨10.1074/jbc.M705559200⟩
The insect steroid hormone 20-hydroxyecdysone (20E) binds to its cognate nuclear receptor composed of the ecdysone receptor (EcR) and Ultraspiracle (USP) and triggers the main developmental transitions, in particular molting and metamorphosis. We pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1db4f3418ea3b70c6c4ca9f317a2769
https://doi.org/10.1074/jbc.m705559200
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6
Raloxifene and ICI182,780 Increase Estrogen Receptor-α Association with a Nuclear Compartment via Overlapping Sets of Hydrophobic Amino Acids in Activation Function 2 Helix 12
Autor: M. Jeyakumar, Anick Auger, Dino Moras, Sylvie Mader, Elise Hébert, Mathieu Lupien, Khalid Hilmi, Geneviève Anne Pinard, David Cotnoir-White, Jean Marie Wurtz, John A. Katzenellenbogen, Guila Dayan, Caroline Loch
Publikováno v: Molecular Endocrinology-Baltimore
Molecular Endocrinology-Baltimore-, Endocrine Society, 2007, 21 (4), pp.797-816. ⟨10.1210/me.2006-0074⟩
The basis for the differential repressive effects of antiestrogens on transactivation by estrogen receptor-α (ERα) remains incompletely understood. Here, we show that the full antiestrogen ICI182,780 and, to a lesser extent, the selective ER modula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e26542ee920cd6150b2b9e5be9a55f
https://doi.org/10.1210/me.2006-0074
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7
The loss of transcriptional inhibition by the photoreceptor-cell specific nuclear receptor (NR2E3) is not a necessary cause of enhanced S-cone syndrome
Autor: Fradot, Mathias, Lorentz, Olivier, Jean-Marie Wurtz, Sahel, Jose-Alain, Leveillard, Thierry
Publikováno v: Molecular Vision
Publons
ResearcherID
Molecular Vision, Molecular Vision, 2007, 13, pp.594-601
Molecular Vision, 2007, 13, pp.594-601
PURPOSE: To investigate functional consequence on photoreceptor-cell specific nuclear receptor (NR2E3) transcriptional activity of enhanced S-cone syndrome (ESCS) mutations localized in ligand binding domain (LBD). METHODS: Point mutations were intro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5897e538749e7dd3aa711c6380937eba
http://europepmc.org/articles/PMC2669504
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8
Unique functional properties of a member of the Fushi Tarazu-Factor 1 family from Schistosoma mansoni
Autor: Benjamin Bertin, Frédérik Oger, Jean-Marie Wurtz, Raymond J. Pierce, Stéphanie Caby, Souphatta Sasorith, J. Cornette
Publikováno v: Biochemical Journal. 382:337-351
SmFtz-F1 (Schistosoma mansoni Fushi Tarazu-Factor 1) belongs to the Ftz-F1 subfamily of nuclear receptors, but displays marked structural differences compared with its mammalian homologues SF-1 (steroidogenic factor-1) or liver receptor homologue-1.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dbdf1a1b4e62912d9fafa3a167125b
https://doi.org/10.1042/bj20040489
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9
Crystal Structures of the Vitamin D Nuclear Receptor Liganded with the Vitamin D Side Chain Analogues Calcipotriol and Seocalcitol, Receptor Agonists of Clinical Importance. Insights into a Structural Basis for the Switching of Calcipotriol to a Receptor Antagonist by Further Side Chain Modification
Autor: Giuseppe D. Tocchini-Valentini, Natacha Rochel, Dino Moras, Jean-Marie Wurtz
Publikováno v: Journal of medicinal chemistry 47 (2004): 1956–1961. doi:10.1021/jm0310582
info:cnr-pdr/source/autori:Tocchini-Valentini G; Rochel N; Wurtz JM; Moras D./titolo:Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor/doi:10.1021%2Fjm0310582/rivista:Journal of medicinal chemistry/anno:2004/pagina_da:1956/pagina_a:1961/intervallo_pagine:1956–1961/volume:47
The plethora of actions of 1alpha,25(OH)(2)D(3) in various systems suggested wide clinical applications of vitamin D nuclear receptor (VDR) ligands in treatments of inflammation, dermatological indication, osteoporosis, cancers, and autoimmune diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b423105dc7a42724f44857a67c28d0
https://doi.org/10.1021/jm0310582
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10
Common characteristics of the human and rhesus macaque CD1e molecules: conservation of biochemical and biological properties during primate evolution
Autor: Catherine Angénieux, Jean Salamero, Dominique Fricker, Jean-Marie Wurtz, Blandine Maître, Jean-Pierre Cazenave, Daniel Hanau, Henri de la Salle
Publikováno v: Scopus-Elsevier
In humans, a family of five genes encodes the CD1 molecules. Four of these proteins, CD1a, b, c, and d, are expressed on the plasma membrane and traffic between the cell surface and endocytic compartments, where they are loaded with antigenic glycoli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dd8b1a0ce436b177b330ea31f8ec63
https://doi.org/10.1007/s00251-003-0538-0
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