Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jean Manuel Pean"'
Autor:
Ali Tfayli, Pierre Chaminade, Olivier Lecoq, Mathieu Boiret, Jean Manuel Pean, Barbara Fayard, Michel Baron, Muriel Genty, Claire Gendre
Publikováno v:
International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2013, 453 (2), pp.448-453. ⟨10.1016/j.ijpharm.2013.06.008⟩
International Journal of Pharmaceutics, Elsevier, 2013, 453 (2), pp.448-453. ⟨10.1016/j.ijpharm.2013.06.008⟩
International audience; Curing is generally required to stabilize film coating from aqueous polymer dispersion. This post-coating drying step is traditionally carried out in static conditions, requiring the transfer of solid dosage forms to an oven.
Autor:
Michel Baron, Marc Julien, Muriel Genty, Olivier Lecoq, Pierre Chaminade, Claire Gendre, Jean Manuel Pean, Loïc Meunier, Mathieu Boiret
Publikováno v:
European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, Elsevier, 2011, 43 (4), pp.244-250. ⟨10.1016/j.ejps.2011.04.017⟩
European Journal of Pharmaceutical Sciences, Elsevier, 2011, 43 (4), pp.244-250. ⟨10.1016/j.ejps.2011.04.017⟩
International audience; The aim of this study was to perform in-line Near Infrared (NIR) measurements inside a pan coater to monitor a coating operation in real-time, by predicting the increases in mass of coating materials and coating thickness. A p
Supramolecular organization of S12363-liposomes prepared with two different remote loading processes
Autor:
Claudie Bourgaux, Jean-Manuel Pean, Georg Pabst, Patrick Couvreur, Michel Ollivon, Caroline Chemin, Patrick Wüthrich
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788(5):926-935
The S12363 anticancer drug was encapsulated into liposomes in an attempt to increase its therapeutic index. Loading of S12363 was achieved using two different processes based on the formation of either a pH gradient or an ammonium gradient between th
Autor:
Georg Pabst, Patrick Couvreur, Jean-Manuel Pean, Michel Ollivon, Claudie Bourgaux, Caroline Chemin, Patrick Wüthrich
Publikováno v:
Chemistry and Physics of Lipids. 153:119-129
For drug delivery purpose the anticancer drug S12363 was loaded into ESM/Chol-liposomes using either a pH or an ammonium gradient. Association between the drug and the liposome depends markedly on the liposome membrane structure. Thus, ESM and ESM/Ch
Autor:
Ali Tfayli, Michel Baron, Julio Cesar da Silva, Pierre Chaminade, Mathieu Boiret, Jean Manuel Pean, Muriel Genty, Claire Gendre, Olivier Lecoq
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2012, 81 (3), p. 657-665. ⟨10.1016/j.ejpb.2012.04.006⟩
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2012, 81 (3), p. 657-665. ⟨10.1016/j.ejpb.2012.04.006⟩
International audience; The dissolution method is still widely used to determine curing end-points to ensure long-term stability of film coatings. Nevertheless, the process of curing has not yet been fully investigated. For the first time, joint tech
Publikováno v:
International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2011, 421 (2), pp.237-243. ⟨10.1016/j.ijpharm.2011.09.036⟩
International Journal of Pharmaceutics, Elsevier, 2011, 421 (2), pp.237-243. ⟨10.1016/j.ijpharm.2011.09.036⟩
The aim of this work was to carry out real-time near infrared (NIR) predictions of drug release from sustained release coated tablets and to determine end point of coating operation. In-line measurements were ensured by implementation of a NIR probe
Autor:
Alain Le Pape, Jean-Manuel Pean, Michèle German-Fattal, Caroline Chemin, Jean-Marie Delbos, Patrick Couvreur, Patrick Wüthrich
Publikováno v:
Journal of Liposome Research. :090730043007050-11
S12363 is a potent therapeutic agent with a strong in vitro activity against a variety of tumor types but also a high in vivo toxicity. Loading of this drug into long-circulating liposomes is expected to enhance its therapeutic index. Pharmacokinetic