Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jean M. Sargent"'
Autor:
Godefridus J. Peters, Gertjan J.L. Kaspers, Jean M. Sargent, U Creutzig, Isabelle Hubeek, Brenda Gibson, A. J. F. Broekhuizen
Publikováno v:
British Journal of Haematology, 131(2), 219-222. Wiley-Blackwell
Hubeek, I, Peters, G J, Broekhuizen, AJ, Sargent, J, Gibson, B E, Creutzig, U & Kaspers, G J L 2005, ' Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia ', British Journal of Haematology, vol. 131, no. 2, pp. 219-222 . https://doi.org/10.1111/j.1365-2141.2005.05760.x
Hubeek, I, Peters, G J, Broekhuizen, AJ, Sargent, J, Gibson, B E, Creutzig, U & Kaspers, G J L 2005, ' Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia ', British Journal of Haematology, vol. 131, no. 2, pp. 219-222 . https://doi.org/10.1111/j.1365-2141.2005.05760.x
To modulate in vitro cytarabine (ara-C) resistance we combined ara-C with six potential resistance modifiers in 10 paediatric acute myeloid leukaemia (AML) patient samples (methyl thiazol tetrazolium assay). Drug interactions were determined by media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510849d7a5555e4caec69e5fc40c2ca9
https://doi.org/10.1111/j.1365-2141.2005.05760.x
https://doi.org/10.1111/j.1365-2141.2005.05760.x
Publikováno v:
Anti-Cancer Drugs. 14:467-473
Tafluposide (F 11782), a novel epipodophylloid with a unique mechanism of interaction with both topoisomerase I and II, has shown outstanding antitumor activity in vivo against a panel of experimental human tumor xenografts. The aim of this study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c38700e8ce8b5496f59c0fd2df01e7
https://doi.org/10.1097/00001813-200307000-00013
https://doi.org/10.1097/00001813-200307000-00013
Autor:
Alena W. Elgie, C. J. Williamson, Paul Britt, Grazyna M. Lewandowicz, Helen M. Coley, Jean M. Sargent, Andrew G. Hall
Publikováno v:
Gynecologic Oncology. 85:298-304
Objectives. The objective was to assess the relationship between glutathione content and drug sensitivity with glutathione modulation in ovarian cancer in a pilot study using 31 samples of freshly obtained ovarian tumor material from 26 patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0478f881a14646e85f5c02c93c10ec2d
https://doi.org/10.1006/gyno.2002.6617
https://doi.org/10.1006/gyno.2002.6617
Autor:
Jean M. Sargent, Rik J. Scheper, Marc Maliepaard, C. J. Williamson, Alena W. Elgie, Colin Taylor
Publikováno v:
British Journal of Haematology. 115:257-262
Breast cancer resistance protein (BCRP) is a recently described member of the ATP binding cassette transporter superfamily. It has been shown to confer resistance to mitoxantrone, topotecan, doxorubicin and daunorubicin in human tumour cell lines. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e88ffab81995e706ef1251e27319d3ee
https://doi.org/10.1046/j.1365-2141.2001.03122.x
https://doi.org/10.1046/j.1365-2141.2001.03122.x
Publikováno v:
Biochemical Pharmacology. 56:1365-1370
Recent studies suggest a dual role for nitric oxide (NO) in tumour biology. High concentrations of NO can mediate tumouricidal activity, whereas lower concentrations have been shown to promote tumour growth. In this study, NO synthase (NOS) activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926303968c687d7c0581a9c5828b58da
https://doi.org/10.1016/s0006-2952(98)00187-7
https://doi.org/10.1016/s0006-2952(98)00187-7
Publikováno v:
Leukemia Research. 20:407-413
We have utilized the MTT assay to measure the metabolic activity of cells from the bone marrow of 55 patients with acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and non-clonal disease. Doubling dilutions of cells were exposed to MTT f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028cd7de665de5d4c4eaa2462abf96a4
https://doi.org/10.1016/0145-2126(95)00163-8
https://doi.org/10.1016/0145-2126(95)00163-8
Autor:
Colin Taylor, Gertjan L. Kaspers, Monique L. den Boer, Jean M. Sargent, Isabelle Hubeek, Godefridus J. Peters, C. J. Williamson, Alena W. Elgie
Publikováno v:
Oncology Reports, 10(6), 2027-2031. Spandidos Publications
Sargent, J M, Williamson, C J, Hubeek, I, Elgie, A W, Taylor, C G, Den Boer, M L, Peters, G J & Kaspers, G L 2003, ' Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia. ', Oncology Reports, vol. 10, no. 6, pp. 2027-2031 . https://doi.org/10.3892/or.10.6.2027
Sargent, J M, Williamson, C J, Hubeek, I, Elgie, A W, Taylor, C G, Den Boer, M L, Peters, G J & Kaspers, G L 2003, ' Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia. ', Oncology Reports, vol. 10, no. 6, pp. 2027-2031 . https://doi.org/10.3892/or.10.6.2027
In order to assess the effect of the DNA polymerase inhibitor aphidicolin on resistance to cytosine arabinoside, blast cells from 15 children with ALL and 9 with AML were exposed to a range of concentrations of ara-C +/- aphidicolin. Cell survival wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef25752f03e5f9f3a81a5f682b080e1
https://pubmed.ncbi.nlm.nih.gov/14534738
https://pubmed.ncbi.nlm.nih.gov/14534738
Autor:
Jean M, Sargent
Publikováno v:
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 161
We have found the short-term MTT assay to be a simple, reproducible chemosensitivity technique, suitable for use throughout the time course of disease. We now have 12 years' experience of using this method in a variety of tumour types, both haematolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3f78cc4407556fd2d4dad4d50bb74c0
https://pubmed.ncbi.nlm.nih.gov/12528795
https://pubmed.ncbi.nlm.nih.gov/12528795
Autor:
Jean M. Sargent
Publikováno v:
Chemosensitivity Testing in Oncology ISBN: 9783642624124
We have found the short-term MTT assay to be a simple, reproducible chemosensitivity technique, suitable for use throughout the time course of disease. We now have 12 years' experience of using this method in a variety of tumour types, both haematolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58c38a4823309853fad70137d88116b
https://doi.org/10.1007/978-3-642-19022-3_2
https://doi.org/10.1007/978-3-642-19022-3_2
Autor:
Helen M, Coley, Jean M, Sargent, Christine J, Williamson, Jenny, Titley, Rik J, Scheper, Sarah E, Gregson, Alena W, Elgie, Grazyna M, Lewandowicz, Colin G, Taylor
Publikováno v:
Anticancer research. 22(1A)
This in vitro feasibility study has assessed a number of techniques and their applicability when looking at the role of multidrug resistance (MDR) in solid tumours. Fresh tumour material was obtained from 34 patients, (11 previously treated, 23 untre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16213087d3d11d0d8b8b626f821f4658
https://pubmed.ncbi.nlm.nih.gov/12017336
https://pubmed.ncbi.nlm.nih.gov/12017336