Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap

Autor: Rhys W. Dunphy, Ayla A. Wahid, Catherine R. Back, Rebecca L. Martin, Andrew G. Watts, Charlotte A. Dodson, Susan J. Crennell, Jean M. H. van den Elsen

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Staphylococcus aureus is an opportunistic pathogen that is able to thwart an effective host immune response by producing a range of immune evasion molecules, including S. aureus binder of IgG (Sbi) which interacts directly with the central complement

Externí odkaz: https://doaj.org/article/0083d9a530604fb783a63ee29957e463

Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant

Autor: Yi Yang, Catherine R. Back, Melissa A. Gräwert, Ayla A. Wahid, Harriet Denton, Rebecca Kildani, Joshua Paulin, Kristin Wörner, Wolgang Kaiser, Dmitri I. Svergun, Asel Sartbaeva, Andrew G. Watts, Kevin J. Marchbank, Jean M. H. van den Elsen

Publikováno v: Frontiers in Immunology, Vol 9 (2019)

Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold required for B cell activation. Consequently, fusions of antigens with C3d polymers have shown gre

Externí odkaz: https://doaj.org/article/e01d806aa3964b4ab66e029fff506fb6

Physiochemical Changes to TTCF Ensilication Investigated Using Time-Resolved SAXS

Autor: Karen J. Edler, Jean M. H. van den Elsen, Aswin Doekhie, Francoise Koumanov, Asel Sartbaeva, Rajeev Dattani, Yun-Chu Chen

Publikováno v: AppliedChem
Volume 1
Issue 1
Pages 2-13
'AppliedChem ', vol: 1, pages: 4-13 (2021)

Successful eradication or control of prevailing infectious diseases is linked to vaccine efficacy, stability, and distribution. The majority of protein-based vaccines are transported at fridge (2–8 °C) temperatures, cold chain, to retain potency.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c145630f63357a3a1844232253cbb998

A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity

Autor: Jean M. H. van den Elsen, Camilla Schjalm, Ole-Lars Brekke, Tom Eirik Mollnes, Soeren Erik Pischke, Grethe Bergseth, Oliver Durrant, Linda M. Haugaard-Kedström, Anne Landsem, Alex Macpherson, Quang Huy Quach, Per H. Nilsson, Hilde Fure, Markus Huber-Lang, Christina Johnson

Publikováno v: J Immunol
Journal of Immunology
Nilsson, P H, Johnson, C, Quach, Q H, Macpherson, A, Durrant, O, Pischke, S E, Fure, H, Landsem, A, Bergseth, G, Schjalm, C, Haugaard-Kedström, L M, Huber-Lang, M, van den Elsen, J, Brekke, O L & Mollnes, T E 2021, ' A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity ', Journal of Immunology, vol. 207, no. 6, pp. 1641-1651 . https://doi.org/10.4049/jimmunol.2001471

Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448dc19a64a17108672b963fe184bed
http://hdl.handle.net/10852/88977

Author response: The allosteric modulation of complement C5 by knob domain peptides

Autor: Susan J. Crennell, Charlotte M. Deane, Vladas Oleinikovas, Ben Holmes, Jean M. H. van den Elsen, Alastair Dg Lawson, James Snowden, Maisem Laabei, Sarah Robinson, Dmitri I. Svergun, Zainab Ahdash, James R. Birtley, Monika-Sarah E. D. Schulze, Victoria Ellis, Alex Macpherson, Melissa A. Graewert, Per H. Nilsson, Tom Eirik Mollnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5aac6f122017b049092e52978a26843
https://doi.org/10.7554/elife.63586.sa2