Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Jean Lucien Rouleau"'
Autor:
Maxime Meloche, Marc-Olivier Pilon, Sylvie Provost, Grégoire Leclair, Essaïd Oussaïd, Isabelle St-Jean, Martin Jutras, Marie-Josée Gaulin, Louis-Philippe Lemieux Perreault, Diane Valois, Ian Mongrain, David Busseuil, Jean-Lucien Rouleau, Jean-Claude Tardif, Marie-Pierre Dubé, Simon de Denus
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 6, p 649 (2024)
Cohort studies have identified several genetic determinants that could predict the clinical response to allopurinol. However, they have not been commonly used for genome-wide investigations to identify genetic determinants on allopurinol metabolism a
Externí odkaz:
https://doaj.org/article/28cfe486b33248c196cecc96d09710f3
Autor:
Jessica Hindi, Marc‐Olivier Pilon, Maxime Meloche, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 5, Pp 872-885 (2023)
Abstract Females present a higher risk of adverse drug reactions. Sex‐related differences in drug concentrations may contribute to these observations but they remain understudied given the underrepresentation of females in clinical trials. The aim
Externí odkaz:
https://doaj.org/article/58f822ad9b2840d0901676770757397e
Autor:
Marc‐Olivier Pilon, Grégoire Leclair, Essaïd Oussaïd, Isabelle St‐Jean, Martin Jutras, Marie‐Josée Gaulin, Ian Mongrain, David Busseuil, Jean Lucien Rouleau, Jean‐Claude Tardif, Marie‐Pierre Dubé, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 2024-2034 (2022)
Abstract ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and poor response to allopurinol, a uric acid
Externí odkaz:
https://doaj.org/article/f9425dbf0f014bcc896fcaa842b04bf7
Autor:
Imad Kassem, Steven Sanche, Jun Li, Guillaume Bonnefois, Marie‐Pierre Dubé, Jean‐Lucien Rouleau, Jean‐Claude Tardif, Michel White, Jacques Turgeon, Fahima Nekka, Simon deDenus
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 194-203 (2021)
Heart failure (HF) causes pathological changes in multiple organs, thus affecting the pharmacokinetics (PK) of drugs. The aim of this study was to investigate the PK of candesartan in patients with HF while examining significant covariates and their
Externí odkaz:
https://doaj.org/article/06648dc786d34810be9652d22f425824
Autor:
Marilyne, Jarjour, Jacinthe, Leclerc, Nadia, Bouabdallaoui, Charaf, Ahnadi, Denis, Brouillette, Simon, de Denus, Annik, Fortier, Patrick, Garceau, Geneviève, Giraldeau, Serge, Lepage, Mark, Liszkowski, Eileen, O'Meara, Marie-Claude, Parent, Normand, Racine, Maxime, Tremblay-Gravel, Michel, White, Jean-Lucien, Rouleau, Anique, Ducharme
Publikováno v:
International Journal of Cardiology. 370:300-308
In heart failure, specific target doses for each drug are recommended, but some patients receive suboptimal dosing, others are undertreated or remain chronically in a titration phase, despite having no apparent contraindication or intolerance. We ass
Autor:
Lauren, Basmadjian, Nadia, Bouabdallaoui, François, Simard, Eileen, O'Meara, Anique, Ducharme, Jean-Lucien, Rouleau, Normand, Racine, Michel, White, Martin G, Sirois, Anita, Asgar, Reda, Ibrahim, Jean-François, Dorval, Raoul, Bonan, Raymond, Cartier, Jessica, Forcillo, Ismail, El-Hamamsy, Christine, Henri
Publikováno v:
The American Journal of Cardiology. 186:11-16
In aortic stenosis (AS), left ventricular (LV) remodeling often occurs before symptom onset, and early intervention may be beneficial. Risk stratification remains challenging and identification of biomarkers may be useful. We evaluated the associatio
Publikováno v:
McGill Journal of Medicine, Vol 11, Iss 1 (2020)
Shone’s anomaly, a congenital cardiac malformation complex, consists of multiple levels of left heart obstruction. A rare case of an incomplete form of this anomaly discovered incidentally during cardiac catheterization for an unrelated event
Externí odkaz:
https://doaj.org/article/933c66a922084cf19c3a7773d3349c0c
Autor:
Roxana Mehran, Philippe Gabriel Steg, Marc A. Pfeffer, Karola Jering, Brian Claggett, Eldrin F. Lewis, Christopher Granger, Lars Køber, Aldo Maggioni, Douglas L. Mann, John J.V. McMurray, Jean-Lucien Rouleau, Scott D. Solomon, Gregory Ducrocq, Otavio Berwanger, Carmine G. De Pasquale, Ulf Landmesser, Mark Petrie, David Sim Kheng Leng, Peter van der Meer, Martin Lefkowitz, Yinong Zhou, Eugene Braunwald
Publikováno v:
Circulation, 146(23), 1749-1757. LIPPINCOTT WILLIAMS & WILKINS
Mehran, R, Steg, P G, Pfeffer, M A, Jering, K, Claggett, B, Lewis, E F, Granger, C, Køber, L, Maggioni, A, Mann, D L, McMurray, J J V, Rouleau, J L, Solomon, S D, Ducrocq, G, Berwanger, O, De Pasquale, C G, Landmesser, U, Petrie, M, Leng, D S K, Van Der Meer, P, Lefkowitz, M, Zhou, Y & Braunwald, E 2022, ' The Effects of Angiotensin Receptor-Neprilysin Inhibition on Major Coronary Events in Patients with Acute Myocardial Infarction : Insights from the PARADISE-MI Trial ', Circulation, vol. 146, no. 23, pp. 1749-1757 . https://doi.org/10.1161/CIRCULATIONAHA.122.060841
Mehran, R, Steg, P G, Pfeffer, M A, Jering, K, Claggett, B, Lewis, E F, Granger, C, Køber, L, Maggioni, A, Mann, D L, McMurray, J J V, Rouleau, J L, Solomon, S D, Ducrocq, G, Berwanger, O, De Pasquale, C G, Landmesser, U, Petrie, M, Leng, D S K, Van Der Meer, P, Lefkowitz, M, Zhou, Y & Braunwald, E 2022, ' The Effects of Angiotensin Receptor-Neprilysin Inhibition on Major Coronary Events in Patients with Acute Myocardial Infarction : Insights from the PARADISE-MI Trial ', Circulation, vol. 146, no. 23, pp. 1749-1757 . https://doi.org/10.1161/CIRCULATIONAHA.122.060841
Background: In patients who survive an acute myocardial infarction (AMI), angiotensin-converting enzyme inhibitors decrease the risk of subsequent major cardiovascular events. Whether angiotensin-receptor blockade and neprilysin inhibition with sacub
Autor:
Marie-A Chaix, Annie Dore, Blandine Mondésert, François-Pierre Mongeon, Véronique Roy, Marie-Claude Guertin, Michel White, Réda Ibrahim, Eileen O’Meara, Jean-Lucien Rouleau, Paul Khairy
Publikováno v:
CJC Open.
Autor:
James P, Curtain, Alice M, Jackson, Li, Shen, Pardeep S, Jhund, Kieran F, Docherty, Mark C, Petrie, Davide, Castagno, Akshay S, Desai, Luis E, Rohde, Martin P, Lefkowitz, Jean-Lucien, Rouleau, Michael R, Zile, Scott D, Solomon, Karl, Swedberg, Milton, Packer, John J V, McMurray
Publikováno v:
European Journal of Heart Failure. 24:551-561
Sudden death is a leading cause of mortality in heart failure with reduced ejection fraction (HFrEF). In PARADIGM-HF, sacubitril/valsartan reduced the incidence of sudden death. The purpose of this post hoc study was to analyse the effect of sacubitr