Výsledky vyhledávání - "Jean Luc Teillaud"

Akademický článek

Absence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammation

Autor: Clémence Riffard, Laïla Letaïef, Safa Azar, Armanda Casrouge, Isabelle Brunet, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Tertiary lymphoid structures (TLS) are lymphoid organs present in inflammatory non-lymphoid tissues. Studies have linked TLS to favorable outcomes for patients with cancers or infectious diseases, but the mechanisms underlying their formatio

Externí odkaz: https://doaj.org/article/c8dc9424248c4f60b04d4f05518a3b45

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Akademický článek

HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy

Autor: Alicia Inés Bravo, Mariana Aris, Marylou Panouillot, Martina Porto, Marie-Caroline Dieu-Nosjean, Jean-Luc Teillaud, María Marcela Barrio, José Mordoh

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionTissue biomarkers that aid in identifying cutaneous melanoma (CM) patients who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor-draining lymph nodes (mTDLN) are the first encounter site between the metast

Externí odkaz: https://doaj.org/article/31317a4b55ec4d338dd8504276aa036a

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Akademický článek

Defining biomarkers in oral cancer according to smoking and drinking status

Autor: Juliette Rochefort, Ioannis Karagiannidis, Claude Baillou, Lisa Belin, Maude Guillot-Delost, Rodney Macedo, Aline Le Moignic, Véronique Mateo, Patrick Soussan, Isabelle Brocheriou, Jean-Luc Teillaud, Marie-Caroline Dieu-Nosjean, Chloé Bertolus, Francois Michel Lemoine, Géraldine Lescaille

Publikováno v: Frontiers in Oncology, Vol 12 (2023)

IntroductionOral Squamous Cell Carcinomas (OSCC) are mostly related to tobacco consumption eventually associated to alcohol (Smoker/Drinker patients: SD), but 25-30% of the patients have no identified risk factors (Non-Smoker/Non-Drinker patients: NS

Externí odkaz: https://doaj.org/article/b577d8cbef2443068f02afd45e239bff

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Akademický článek

Potent immunomodulatory and antitumor effect of anti-CD20-IL2no-alpha tri-functional immunocytokine for cancer therapy

Autor: Ana Victoria Casadesús, Beatriz María Cruz, Wilden Díaz, Miguel Ángel González, Tania Gómez, Briandy Fernández, Addys González, Nuris Ledón, Katya Sosa, Kathleen Castro, Armando López, Claudia Plasencia, Yaima Ramírez, Jean-Luc Teillaud, Calixto Hernández, Kalet León, Tays Hernández

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionThe anti-CD20 antibody rituximab (RTX) has substantially improved outcomes of patients with B-cell lymphomas, although more efficient therapies are needed for refractory or relapsing lymphomas. An approach to increase the clinical effecti

Externí odkaz: https://doaj.org/article/27dd8b21477249bb9be6a6d8cabd48c2

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Akademický článek

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Autor: Charlotte Domblides, Juliette Rochefort, Clémence Riffard, Marylou Panouillot, Géraldine Lescaille, Jean-Luc Teillaud, Véronique Mateo, Marie-Caroline Dieu-Nosjean

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The tumor microenvironment is a complex ecosystem almost unique to each patient. Most of available therapies target tumor cells according to their molecular characteristics, angiogenesis or immune cells involved in tumor immune-surveillance. Unfortun

Externí odkaz: https://doaj.org/article/56ee399f2cc542a08fe0712c87e4c971

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Akademický článek

Tertiary Lymphoid Structure-B Cells Narrow Regulatory T Cells Impact in Lung Cancer Patients

Autor: Claire Germain, Priyanka Devi-Marulkar, Samantha Knockaert, Jérôme Biton, Hélène Kaplon, Laïla Letaïef, Jérémy Goc, Agathe Seguin-Givelet, Dominique Gossot, Nicolas Girard, Pierre Validire, Marine Lefèvre, Diane Damotte, Marco Alifano, François M. Lemoine, Keith E. Steele, Jean-Luc Teillaud, Scott A. Hammond, Marie-Caroline Dieu-Nosjean

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is associated with better clinical outcome in many cancers. In non-small cell lung cancer (NSCLC), we have previously showed that a high density of B cells within TLS (T

Externí odkaz: https://doaj.org/article/757b1a291fa64d989f66f304930a5ace

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Akademický článek

A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy

Autor: Ana Victoria Casadesús, Claire Deligne, Béré Kadjdiatou Diallo, Katya Sosa, Nathalie Josseaume, Circe Mesa, Kalet León, Tays Hernández, Jean-Luc Teillaud

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

Anti-CD20 treatment represents a therapeutic benefit for patients with B-cell lymphomas, although more efficient therapies are needed for refractory or relapsing patients. Among them, the combination of anti-CD20 and IL-2 that induces T cell response

Externí odkaz: https://doaj.org/article/3bcd9f905d40474e9def20f2e1f193b8

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