Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jean Luc Specklin"'
Autor:
Peter Seiler, L. Jacob, Swen Seeland, S. Diethelm, N. Tidten-Luksch, Jean-Philippe Surivet, M. Wicki, Georg Rueedi, Jean-Luc Specklin, Michel Enderlin-Paput, Christian Hubschwerlen, Azely Mirre, R. Lange, G. Mathieu, Christine Schmitt, C. Herrmann, Philippe Panchaud, A.-C. Blumstein, A. Mac Sweeney, F. Masse, Daniel Ritz, Jean-Christophe Gauvin, Carmela Gnerre
Publikováno v:
Journal of Medicinal Chemistry. 63:66-87
UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive target for the discovery and development of novel antibacterial drugs to address the critical medical need created by multidrug resistant Gram-negative bacteria. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae4ad619b6cf3e0f3c6f741f71c0456
https://doi.org/10.1021/acs.jmedchem.9b01604
https://doi.org/10.1021/acs.jmedchem.9b01604
Autor:
Jean Luc Specklin, Christian Hubschwerlen, Hans H. Locher, Christine Sigwalt, Susanne Schroeder
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:2313-2319
Oxazolidinone-quinolone hybrids that combine the pharmacophores of a quinolone and an oxazolidinone were synthesised and shown to be active against a variety of resistant and susceptible Gram-positive and fastidious Gram-negative organisms. The best
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b2a7686156d304b4709ba0136766cd
https://doi.org/10.1016/s0968-0896(03)00083-x
https://doi.org/10.1016/s0968-0896(03)00083-x
Autor:
and Jean-Luc Specklin, Fritz K. Winkler, Peter Angehrn, Malgosia Kania, Hans Richter, Christian Hubschwerlen, Malcolm G. P. Page
Publikováno v:
Journal of Medicinal Chemistry. 39:3712-3722
A general method for synthesis of 2 beta-alkenyl penam sulfones has been developed. The new compounds inhibited most of the common types of beta-lactamase. The level of activity depended very strongly on the nature of the substituent in the 2 beta-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d31a376f6eab8cce598c7100cec6b0f
https://doi.org/10.1021/jm9601967
https://doi.org/10.1021/jm9601967
Autor:
Daniel Ritz, Alain Chambovey, Alcibiade Athanasiou, Nadia Ekambaram, Daniela Sabato, Mika Gaertner, Daniel S. Strasser, Michel Enderlin, R. Lange, Pierre Wyss, Christopher Kohl, Wolfgang Keck, Maria Boehme, Gaelle Chapoux, Lars Prade, Jean-Luc Specklin, Peter Seiler, Christine Schmitt, Christian Hubschwerlen, Virginie Sippel, Jean-Philippe Surivet, Eser Ilhan, Andreja Knezevic, Hans H. Locher, Daniel Bur
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(21)
A series of 2-amino-[1,8]-naphthyridine-3-carboxamides (ANCs) with potent inhibition of bacterial NAD+-dependent DNA ligases (LigAs) evolved from a 2,4-diaminopteridine derivative discovered by HTS. The design was guided by several highly resolved X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28ce0a143d3d58078bbea3e3c8a168b
https://pubmed.ncbi.nlm.nih.gov/23006603
https://pubmed.ncbi.nlm.nih.gov/23006603
Publikováno v:
Synlett. 2001:0538-0540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af1d50bd49a289cf6fbb47333d924c85
https://doi.org/10.1055/s-2001-12311
https://doi.org/10.1055/s-2001-12311
Autor:
Hans Gmuender, Peter Angehrn, Christian Hubschwerlen, Philippe Pflieger, Klaus Gubernator, Jean-Luc Specklin, Ivan Kompis
Publikováno v:
ChemInform. 24
Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede04cda0a2517a47dbe70e543745aa7
https://doi.org/10.1002/chin.199301207
https://doi.org/10.1002/chin.199301207
Autor:
Klaus Gubernator, Peter Angehrn, Jean-Luc Specklin, Malcolm G. P. Page, Christian Hubschwerlen
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb8f7494b667baa0d1eee17f03c5259
https://doi.org/10.1002/chin.199911131
https://doi.org/10.1002/chin.199911131
Autor:
Hans H. Locher, Christine Sigwalt, Susanne Schroeder, Christian Hubschwerlen, Daniel K. Baeschlin, Sascha Haefeli, Yves Borer, Jean-Luc Specklin
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(23)
Oxazolidinone-quinolone hybrids, which combine the pharmacophores of a quinolone and an oxazolidinone, were synthesised and shown to be active against a variety of susceptible and resistant Gram-positive and Gram-negative bacteria. The nature of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6571c1d499751c3207e92f40a1a440b9
https://pubmed.ncbi.nlm.nih.gov/14623007
https://pubmed.ncbi.nlm.nih.gov/14623007
Publikováno v:
Organic Syntheses
l-(S)-glyceraldehyde acetonide product: L-(S)-glyceraldehyde acetonide Keywords: cleavage, oxidative; oxidation, miscellaneous; ring opening reactions; titrator, automatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6131fda0659a61f29df153252b5b88f9
https://doi.org/10.1002/0471264180.os072.01
https://doi.org/10.1002/0471264180.os072.01
Publikováno v:
Organic Syntheses
(3S,4S)-3-amino-1-(3,4-dimethoxybenzyl)-4-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-azetidinone intermediate: 100 g of phthalylglycyl chloride (90% based on phthalylglycine) product: (3S,4S)-3-amino-1-(3,4-dimethoxybenzyl)-4-[(R)-2,2-dimethyl-1,3-dioxol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a41fb1f8dfcd953901d3521b42093c3
https://doi.org/10.1002/0471264180.os072.03
https://doi.org/10.1002/0471264180.os072.03