Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jean Luc Guillaume"'
Autor:
Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journé, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and sho
Externí odkaz:
https://doaj.org/article/ee01b8e19b6d47e3a5db8a61ae00a911
Autor:
Bianca Plouffe, Angeliki Karamitri, Tilman Flock, Jonathan M. Gallion, Shane Houston, Carole A. Daly, Amélie Bonnefond, Jean-Luc Guillaume, Christian Le Gouill, Phillipe Froguel, Olivier Lichtarge, Xavier Deupi, Ralf Jockers, Michel Bouvier
Publikováno v:
Plouffe, B, Karamitri, A, Flock, T, Gallion, J M, Houston, S, Daly, C A, Bonnefond, A, Guillaume, J-L, Le Gouill, C, Froguel, P, Lichtarge, O, Deupi, X, Jockers, R & Bouvier, M 2022, ' Structural elements directing G proteins and β-arrestin interactions with the human melatonin type 2 receptor revealed by natural variants ', ACS Pharmacology & Translational Science, vol. 5, no. 2, pp. 89-101 . https://doi.org/10.1021/acsptsci.1c00239
G protein-coupled receptors (GPCRs) can engage distinct subsets of signaling pathways, but the structural determinants of this functional selectivity remain elusive. The naturally occurring genetic variants of GPCRs, selectively affecting different p
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2550
Cyclic adenosine monophosphate (cAMP) is an important ubiquitous second messenger and one of the major pathways transducing the activation of G protein-coupled receptors (GPCRs). Quantifying intracellular levels of cAMP in an accurate and high-throug
Publikováno v:
Melatonin ISBN: 9781071625927
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75fda70c0b3c752504109845f4fbd899
https://doi.org/10.1007/978-1-0716-2593-4_22
https://doi.org/10.1007/978-1-0716-2593-4_22
Autor:
Ralf Jockers, Philippe Chavatte, Kenjiro Tadagaki, Nicolas Renault, Francis Cogé, Xavier Laurent, Arnaud Gohier, Nathalie Clement, Jean-Luc Guillaume, Erika Cecon, Philippe Delagrange, Anne-Sophie Journé
Publikováno v:
British Journal of Pharmacology. 175:3281-3297
Background and purpose Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and receptor activation. Here, we have assessed the role of the E2 loop in
Autor:
Pauline Chaste, Nathalie Clement, Oriane Mercati, Jean-Luc Guillaume, Richard Delorme, Hany Goubran Botros, Cécile Pagan, Samuel Périvier, Isabelle Scheid, Gudrun Nygren, Henrik Anckarsäter, Maria Rastam, Ola Ståhlberg, Carina Gillberg, Emilie Serrano, Nathalie Lemière, Jean Marie Launay, Marie Christine Mouren-Simeoni, Marion Leboyer, Christopher Gillberg, Ralf Jockers, Thomas Bourgeron
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11495 (2010)
Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration of the melatonin pathway has been reported in circadian disorders, diabetes and autism spectrum disorders (ASD). However, very little is known about th
Externí odkaz:
https://doaj.org/article/db5bfbc334f143c8acb3c470126be6b5
Autor:
Anissa Sidibe, Sophie E. Polo, Olivier Lahuna, Avais Daulat, Ralf Jockers, Raise Ahmad, Sarah Gallet, Philippe Delagrange, Marine Luka, Jean-Luc Guillaume, Julie Dam, François Guillonneau, Qiang Zhang, Juliette Hamroune, Vincent Prevot
Publikováno v:
Cellular and molecular life sciences : CMLS. 77(24)
Transmission of extracellular signals by G protein-coupled receptors typically relies on a cascade of intracellular events initiated by the activation of heterotrimeric G proteins or β-arrestins followed by effector activation/inhibition. Here, we r
Autor:
Angeliki, Karamitri, Bianca, Plouffe, Amélie, Bonnefond, Min, Chen, Jonathan, Gallion, Jean-Luc, Guillaume, Alan, Hegron, Mathilde, Boissel, Mickaël, Canouil, Claudia, Langenberg, Nicholas J, Wareham, Christian, Le Gouill, Viktoria, Lukasheva, Olivier, Lichtarge, Philippe, Froguel, Michel, Bouvier, Ralf, Jockers
Publikováno v:
Science signaling. 11(545)
Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in
Autor:
Alan Hégron, Ralf Jockers, Jonathan Gallion, Viktoria Lukasheva, Angeliki Karamitri, Michel Bouvier, Amélie Bonnefond, Min Chen, Olivier Lichtarge, Nicholas J. Wareham, Philippe Froguel, Bianca Plouffe, Mathilde Boissel, Claudia Langenberg, Jean Luc Guillaume, Mickaël Canouil, Christian Le Gouill
Publikováno v:
Science Signaling. 11
Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-function variants in MTNR1B , which encodes the melatonin receptor MT 2 , a G protein–coupled receptor (GPCR), are associated with an increased risk of type 2
Autor:
Amélie Bonnefond, Philippe Froguel, Tilman Flock, Michel Bouvier, Christian Le Gouill, Ralf Jockers, Angeliki Karamitri, Bianca Plouffe, Jonathan M. Gallion, Olivier Lichtarge, Jean-Luc Guillaume, Xavier Deupi
Publikováno v:
ResearcherID