Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Jean Louis Merlin"'
Autor:
Julie Dardare, Andréa Witz, Margaux Betz, Aurélie François, Laureline Lamy, Marie Husson, Jessica Demange, Marie Rouyer, Aurélien Lambert, Jean-Louis Merlin, Pauline Gilson, Alexandre Harlé
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Therapeutic options for PDAC are primarily restricted to surgery in the early stages of the disease or chemotherapy in advanced disease. Only a subset of patients with
Externí odkaz:
https://doaj.org/article/f812e69c8e8e400f9dc2fa11b2a0a91f
Autor:
Zilal Kattan, Sophie Marchal, Emilie Brunner, Carole Ramacci, Agnès Leroux, Jean Louis Merlin, Lionel Domenjoud, Michel Dauça, Philippe Becuwe
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e2002 (2008)
The Damaged DNA binding protein 2 (DDB2), is involved in nucleotide excision repair as well as in other biological processes in normal cells, including transcription and cell cycle regulation. Loss of DDB2 function may be related to tumor susceptibil
Externí odkaz:
https://doaj.org/article/033326b0416b49318d4b7601da8bcd11
Autor:
Andréa Witz, Julie Dardare, Aurélie Francois, Marie Husson, Marie Rouyer, Jessica Demange, Jean-Louis Merlin, Pauline Gilson, Alexandre Harlé
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Pancreatic cancer is one of the most aggressive diseases with a very poor outcome. Olaparib, a PARP inhibitor, as maintenance therapy showed benefits in patients with metastatic pancreatic adenocarcinoma bearing germline BRCA1/2 mutations. H
Externí odkaz:
https://doaj.org/article/9880545833874a948d6b63b019ad89aa
Autor:
Pauline Gilson, Celso Pouget, Richard Belmonte, Smahane Fadil, Jessica Demange, Marie Rouyer, Julien Lacour, Margaux Betz, Julie Dardare, Andréa Witz, Jean-Louis Merlin, Alexandre Harlé
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Gene fusions and MET exon skipping drive oncogenesis in 8–9% and 3% of non-small cell lung cancers (NSCLC) respectively. Their detection are essential for the management of patients since they confer sensitivity to specific targeted therap
Externí odkaz:
https://doaj.org/article/20406c264bfb4ec3b46fea9ad92a6877
Autor:
Lionnel Geoffrois, Alexandre Harlé, Nassim Sahki, Aleksandra Sikanja, Florence Granel-Brocard, Alice Hervieu, Laurent Mortier, Géraldine Jeudy, Catherine Michel, Charlée Nardin, Cécile Huin-Schohn, Jean-Louis Merlin
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Background With more than 15,000 new cases /year in France and 2,000 deaths, cutaneous melanoma represents approximately 4% of incidental cancers and 1.2% of cancer related deaths. In locally advanced (stage III) or resectable metastatic (st
Externí odkaz:
https://doaj.org/article/e9e8f4b43a4c4f71addb8481df90fdbe
Autor:
Jean-Louis Merlin, Marie Husson, Nassim Sahki, Pauline Gilson, Vincent Massard, Alexandre Harlé, Agnès Leroux
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3164 (2023)
Based on immunohistochemistry (IHC) and in situ hybridization (ISH), HER2-low breast cancers (BC) subtype—defined as IHC1+ or IHC2+/ISH− tumors—emerged and represent more than half of all BC. We evaluated the performance of NGS for integrated m
Externí odkaz:
https://doaj.org/article/859b1a757f9b4feeb2983e4b254eb6c8
Autor:
Julie Dardare, Andréa Witz, Margaux Betz, Aurélie Francois, Morgane Meras, Laureline Lamy, Aurélien Lambert, Stéphanie Grandemange, Marie Husson, Marie Rouyer, Jessica Demange, Jean-Louis Merlin, Alexandre Harlé, Pauline Gilson
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionDamage specific DNA binding protein 2 (DDB2) is an UV-indiced DNA damage recognition factor and regulator of cancer development and progression. DDB2 has dual roles in several cancers, either as an oncogene or as a tumor suppressor gene,
Externí odkaz:
https://doaj.org/article/a3ca4813d8d344d2a4dc2b42439f7ed6
Autor:
Lydie Lemoine, Virginie Adam, Xavier Galus, Pascale Siles, Agnès Coulon, Jeannette Grenier-Desforges, Joseph Orabona, Isabelle Kergastel, Pierre Wagner, Julia Salleron, Priscillia Tosti, Cécile Huin-Schohn, Jean-Louis Merlin, Rémi Etienne, Philippe Henrot
Publikováno v:
Frontiers in Psychology, Vol 13 (2022)
BackgroundSurgery is a cornerstone of breast cancer management. Prior to surgery, a wire marker is placed at the site of the tumor, to enable the surgeon to accurately localize the lesion during later surgery. This procedure can generate considerable
Externí odkaz:
https://doaj.org/article/83d284888d8b4f8f8a5841b249eda9f6
Autor:
Pauline Gilson, Chloé Saurel, Julia Salleron, Marie Husson, Jessica Demange, Jean-Louis Merlin, Alexandre Harlé
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The assessment of EGFR mutations is recommended for the management of patients with non-small cell lung cancer (NSCLC). Presence of EGFR mutation is associated with response or resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI). Liquid
Externí odkaz:
https://doaj.org/article/fc3985c683904c09b7333785819ae903
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Diagnosis of lung cancer can sometimes be challenging and is of major interest since effective molecular-guided therapies are available. Compounds of tobacco smoke may generate a specific substitutional signature in lung, which is the most e
Externí odkaz:
https://doaj.org/article/b87948ed20474dea8a6fabbf8e342a86