Zobrazeno 1 - 10
of 374
pro vyhledávání: '"Jean Louis Mergny"'
Autor:
Sandra Albenque-Rubio, Jean Guillon, Patrice Agnamey, Céline Damiani, Solène Savrimoutou, Romain Mustière, Noël Pinaud, Stéphane Moreau, Jean-Louis Mergny, Luisa Ronga, Ioannis Kanavos, Mathieu Marchivie, Serge Moukha, Pascale Dozolme, Pascal Sonnet, Anita Cohen
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 3, Pp 615-637 (2024)
By taking into account our previously described series of 1,3,5-tris[(4-(substituted-aminomethyl)phenyl)methyl]benzene compounds, we have now designed, prepared, and evaluated in vitro against Plasmodium falciparum a novel series of structural analog
Externí odkaz:
https://doaj.org/article/9dd6625364864c06b8baee9fd5429344
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Background Cis-regulatory elements (CREs) are crucial for regulating gene expression, and G-quadruplexes (G4s), as prototypal non-canonical DNA structures, may play a role in this regulation. However, the relationship between G4s and CREs, e
Externí odkaz:
https://doaj.org/article/4696065c6eba4fd4af429a9c6c31cad6
Autor:
Pavlína Víšková, Eva Ištvánková, Jan Ryneš, Šimon Džatko, Tomáš Loja, Martina Lenarčič Živković, Riccardo Rigo, Roberto El-Khoury, Israel Serrano-Chacón, Masad J. Damha, Carlos González, Jean-Louis Mergny, Silvie Foldynová-Trantírková, Lukáš Trantírek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract I-Motifs (iM) are non-canonical DNA structures potentially forming in the accessible, single-stranded, cytosine-rich genomic regions with regulatory roles. Chromatin, protein interactions, and intracellular properties seem to govern iM forma
Externí odkaz:
https://doaj.org/article/dccb82735cd744549a5a5749aaeca993
Autor:
Dehui Qiu, Fangni He, Yuan Liu, Zhaoxi Zhou, Yuqin Yang, Zhongwen Long, Qianqian Chen, Desheng Chen, Shijiong Wei, Xuanxiang Mao, Xiaobo Zhang, Jean‐Louis Mergny, David Monchaud, Huangxian Ju, Jun Zhou
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Nanomaterials excel in mimicking the structure and function of natural enzymes while being far more interesting in terms of structural stability, functional versatility, recyclability, and large‐scale preparation. Herein, the story assembl
Externí odkaz:
https://doaj.org/article/b5bfed1fb01d427da8f9022e340e5f7e
Publikováno v:
ACS Omega, Vol 9, Iss 3, Pp 4096-4101 (2024)
Externí odkaz:
https://doaj.org/article/03410ad38e324c989b9624ad1227585e
Autor:
Sandra Albenque-Rubio, Jean Guillon, Anita Cohen, Patrice Agnamey, Solène Savrimoutou, Stéphane Moreau, Jean-Louis Mergny, Luisa Ronga, Ioannis Kanavos, Serge Moukha, Pascale Dozolme, Pascal Sonnet
Publikováno v:
Drugs and Drug Candidates, Vol 2, Iss 3, Pp 653-672 (2023)
A series of new 1,3,5-tris[(4-(substituted-aminomethyl)phenyl)methyl]benzene compounds were designed, synthesized, and evaluated in vitro against two parasites (Plasmodium falciparum and Leishmania donovani). The biological results showed antimalaria
Externí odkaz:
https://doaj.org/article/bdd938b10c1b4bb98aa4ee3218e77016
Autor:
María José Lista, Anne-Caroline Jousset, Mingpan Cheng, Violaine Saint-André, Elouan Perrot, Melissa Rodrigues, Carmelo Di Primo, Danielle Gadelle, Elenia Toccafondi, Emmanuel Segeral, Clarisse Berlioz-Torrent, Stéphane Emiliani, Jean-Louis Mergny, Marc Lavigne
Publikováno v:
Retrovirology, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by the cellular transcription machinery. This process is regulated by both viral and cellular factors, which are necessary for an efficient viral repli
Externí odkaz:
https://doaj.org/article/65621dcf79434469bcd31a159108beb5
Autor:
Jean Guillon, Marc Le Borgne, Vittoria Milano, Aurore Guédin-Beaurepaire, Stéphane Moreau, Noël Pinaud, Luisa Ronga, Solène Savrimoutou, Sandra Albenque-Rubio, Mathieu Marchivie, Haouraa Kalout, Charley Walker, Louise Chevallier, Corinne Buré, Eric Largy, Valérie Gabelica, Jean-Louis Mergny, Virginie Baylot, Jacky Ferrer, Yamina Idrissi, Edith Chevret, David Cappellen, Vanessa Desplat, Zsuzsanna Schelz, István Zupkó
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 30 (2023)
The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines 12 and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines 13 are reported here in six steps starting from various halogeno-quinazoline-2,4-(1H,3H)-diones or subst
Externí odkaz:
https://doaj.org/article/a1792b25a47e4834a049e8058f8ad1b4
Autor:
Annalisa Ferino, Julien Marquevielle, Himanshi Choudhary, Giorgio Cinque, Coralie Robert, Anne Bourdoncle, Raffaella Picco, Jean-Louis Mergny, Gilmar F. Salgado, Luigi E. Xodo
Publikováno v:
ACS Omega, Vol 6, Iss 49, Pp 34092-34106 (2021)
Externí odkaz:
https://doaj.org/article/6d6584fbad484cc3a33b03455540ba6a
Autor:
Václav Brázda, Otília Porubiaková, Alessio Cantara, Natália Bohálová, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investigated the presence and variation of potenti
Externí odkaz:
https://doaj.org/article/d4b6c14a62d845a4aef0d4fb874488bd