Výsledky vyhledávání - "Jean Lepagnol"

Involvement of nicotinergic mechanisms in thyrotropin-releasing hormone-induced neurologic recovery after concussive head injury in the mouse

Autor: Pierre Lestage, Marie-Hélène Gandon, Jean Lepagnol, Anne Iris-Hugot

Publikováno v: European Journal of Pharmacology. 357:163-169

A behavioral study was performed in an attempt to understand the neuronal mechanisms involved in the thyrotropin-releasing hormone (TRH)-induced improvement of consciousness after concussive head injury in the mouse. Intravenous administration of TRH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1995514ac3ef24c6018c38612dcb882c
https://doi.org/10.1016/s0014-2999(98)00562-7

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Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator

Autor: P. Morain, Bernard Serkiz, Jean Lepagnol, Alex Cordi, P. Desos

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:3003-3008

Enantioselective reduction of pyrrolo-benzothiadiazine 6 using various chiral reducing agents has been studied and led to efficient synthesis of 8 (S 18986) which was established to be of (S) configuration by single crystal X-ray diffraction analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faad10b0f65adf4b6e0b537713ade5f8
https://doi.org/10.1016/s0960-894x(96)00547-1

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Structure−Activity Relationships in a Series of 2(1H)-Quinolones Bearing Different Acidic Function in the 3-Position: 6,7-Dichloro-2(1H)-oxoquinoline-3-phosphonic Acid, a New Potent and Selective AMPA/Kainate Antagonist with Neuroprotective Properties

Autor: Jean Lepagnol, Alex Cordi, Pierre Lestage, Philippe Morain, Patrice Desos

Publikováno v: Journal of Medicinal Chemistry. 39:197-206

Recently, we reported the synthesis of 3-(sulfonylamino)-2(1H)-quinolones, a new series of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate and N-methyl-D-aspartic acid (NMDA)/glycine antagonists. By exploring the structure-act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a529aac95eb71b48d20e3fb1ab86de
https://doi.org/10.1021/jm950323j

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Identification and characterisation of the isomers of cyclothiazide responsible for potentiating ampa current

Autor: Guillaume De Nanteuil, Alex Cordi, Bernard Serkiz, Jean-Pierre Mahieu, Christine Bobichon, Jean Lepagnol, Philippe Hennig

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1957-1960

The four diastereoisomers of cyclothiazide have been separated by chromatography. The most potent fraction was split further into two enantiomers by chiral HPLC. The most active isomer is five times more potent than cyclothiazide in potentiating AMPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4d4176f8a15d309b4468814f58d46bd
https://doi.org/10.1016/s0960-894x(01)80542-4

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ChemInform Abstract: Structure-Activity Relationships in a Series of 2(1H)-Quinolones Bearing Different Acidic Function in the 3-Position: 6,7-Dichloro-2(1H) -oxoquinoline-3-phosphonic Acid, a New Potent and Selective AMPA/ Kainate Antagonist with Neuropr

Autor: Alex Cordi, Philippe Morain, Patrice Desos, Pierre Lestage, Jean Lepagnol

Publikováno v: ChemInform. 27

Recently, we reported the synthesis of 3-(sulfonylamino)-2(1H)-quinolones, a new series of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate and N-methyl-d-aspartic acid (NMDA)/gl...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f73a504a0f22b440f2a26783e2ed9b3e
https://doi.org/10.1002/chin.199618165

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ChemInform Abstract: Enantioselective Synthesis of a Pyrrolo-Benzothiadiazine Derivative S 18986, a New AMPA Receptor Positive Modulator

Autor: P. Morain, Alex Cordi, Jean Lepagnol, P. Desos, Bernard Serkiz

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb501d49d6ee754e1931b04345141261
https://doi.org/10.1002/chin.199723194

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Safety and Clinical Efficacy of S12024 in Patients with Mild to Moderate Alzheimer’s Disease

Autor: Hervé Allain, Eric Neuman, David Guez, Muriel Malbezin, Jean Lepagnol, Florence Mahieux

Publikováno v: Alzheimer Disease ISBN: 9781461286608

The selection of S12024 as a candidate for the treatment of core symptoms of Alzheimer’s disease (AD) was based upon the central noradrenergic and/or vasopressinergic implication hypothesis of AD (Palmer et al., 1987, Van Ree et al., 1985) and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed492cb100f43e1f84a0a1bab42c5189
https://doi.org/10.1007/978-1-4612-4116-4_45

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Pharmacology of sodium and calcium channel modulation in neurons: implications for neuroprotection

Autor: Jean Lepagnol, Michael Spedding

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5c983bb86b7d0df8152fea3a4696c9
https://pubmed.ncbi.nlm.nih.gov/8566432

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Structure-activity relationships in a series of 3-sulfonylamino-2-(1H)-quinolones, as new AMPA/kainate and glycine antagonists

Autor: John Randle, Alex Cordi, Patrice Desos, Jean Lepagnol

Publikováno v: Bioorganicmedicinal chemistry. 3(2)

This paper describes the design and synthesis of a new class of molecules, the 3-sulfonylamino-2-(1 H)-quinolones, which are potent and selective antagonists at both the AMPA/kainate site as well as at the NMDA-associated glycine site. The molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785a4f130cde3561c618a8c708a8001d
https://pubmed.ncbi.nlm.nih.gov/7540921

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