Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Jean Langhorne"'
Autor:
Aida S. Badiane, Bassirou Ngom, Tolla Ndiaye, Deirdre Cunningham, James Campbell, Amy Gaye, Aita Sène, Mouhamad Sy, Daouda Ndiaye, Davis Nwakanma, Jean Langhorne
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently Plasmodium vivax ha
Externí odkaz:
https://doaj.org/article/2325060f03b64344bac1bef461142564
Autor:
Kelvin M. Kimenyi, Mercy Y. Akinyi, Kioko Mwikali, Tegan Gilmore, Shaban Mwangi, Elisha Omer, Bonface Gichuki, Juliana Wambua, James Njunge, George Obiero, Philip Bejon, Jean Langhorne, Abdirahman Abdi, Lynette Isabella Ochola-Oyier
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance of ch
Externí odkaz:
https://doaj.org/article/3d80abee0eab4fcf961678f134020580
Autor:
Deirdre A. Cunningham, Adam J. Reid, Caroline Hosking, Katrien Deroost, Irene Tumwine-Downey, Mandy Sanders, Jean Langhorne
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-6 (2023)
Abstract Objective To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. Results Infected red blood cells containing female and mal
Externí odkaz:
https://doaj.org/article/543e7df693c44e5689deb60f50bbb505
Autor:
Irene Tumwine-Downey, Katrien Deroost, Prisca Levy, Sarah McLaughlin, Caroline Hosking, Jean Langhorne
Publikováno v:
Current Research in Immunology, Vol 4, Iss , Pp 100054- (2023)
Advances in transcriptomics and proteomics have revealed that different life-cycle stages of the malaria parasite, Plasmodium, share antigens, thus allowing for the possibility of eliciting immunity to a parasite life-cycle stage that has not been ex
Externí odkaz:
https://doaj.org/article/995bee4633f94ac58122874fca25c04b
Autor:
Timothy S. Little, Deirdre A. Cunningham, Audrey Vandomme, Carlos Talavera Lopez, Sarah Amis, Christopher Alder, John W. G. Addy, Sarah McLaughlin, Caroline Hosking, George Christophides, Adam J. Reid, Jean Langhorne
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021)
Abstract Background Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, immun
Externí odkaz:
https://doaj.org/article/9efaea334f8249f48589d96afa34ed43
Autor:
Maria Giorgalli, Deirdre A. Cunningham, Malgorzata Broncel, Aaron Sait, Thomas E. Harrison, Caroline Hosking, Audrey Vandomme, Sarah I. Amis, Ana Antonello, Lauren Sullivan, Faith Uwadiae, Laura Torella, Matthew K. Higgins, Jean Langhorne
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Plasmodium multigene families are thought to play important roles in the pathogenesis of malaria. Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium species. However, their expression pattern and local
Externí odkaz:
https://doaj.org/article/fdfc5059f3df4ec5b76c252da4225093
Autor:
Katrien Deroost, Christopher Alder, Caroline Hosking, Sarah McLaughlin, Jing-Wen Lin, Matthew D. Lewis, Yolanda Saavedra-Torres, John W.G. Addy, Prisca Levy, Maria Giorgalli, Jean Langhorne
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 104-119 (2021)
Natural infection with Plasmodium parasites, the causative agents of malaria, occurs via mosquito vectors. However, most of our knowledge of the immune response to the blood stages of Plasmodium is from infections initiated by injection of serially b
Externí odkaz:
https://doaj.org/article/88d8d5187204480e8020e24d9da943ac
Autor:
Jedida Mwacharo, Matt Berriman, Jean Langhorne, Francis M. Ndungu, Kevin Marsh, Jennifer Musyoki, John W.G. Addy, John Joseph Valletta, Joyce Mwongeli Ngoi, Philip Bejon, Yaw Bediako, Mario Recker, Joshua Wambua, Adam J. Reid, Chris I. Newbold, Khadija Said Mohammed, Edward Otieno
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
After decades of research, our understanding of when and why individuals infected with Plasmodium falciparum develop clinical malaria is still limited. Correlates of immune protection are often sought through prospective cohort studies, where measure
Externí odkaz:
https://doaj.org/article/63369b7637934cea969bd98baf984384
Autor:
John Joseph Valetta, Jedida Mwacharo, Matthew Berriman, Jean Langhorne, Francis M. Ndungu, Kevin Marsh, Jennifer Musyoki, John W.G. Addy, Joyce Mwongeli Ngoi, Yaw Bediako, Philip Bejon, Mario Recker, Joshua Wambua, Adam J. Reid, Edward Otieno, Khadija Said Mohammed
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: Studies of long-term malaria cohorts have provided essential insights into how Plasmodium falciparum interacts with humans, and influences the development of antimalarial immunity. Immunity to malaria is acquired gradually after multiple
Externí odkaz:
https://doaj.org/article/3c6460d553e64a7b9d05aef883a961a6
Autor:
Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Jonathan M. Pitt, Probir Chakravarty, Annika Warnatsch, William J. Branchett, Laura Conejero, Jing-Wen Lin, Sophia Davidson, Mark S. Wilson, Gregory Bancroft, Jean Langhorne, Eva Frickel, Abdul K. Sesay, Simon L. Priestnall, Eleanor Herbert, Marianna Ioannou, Qian Wang, Ian R. Humphreys, Jonathan Dodd, Peter J. M. Openshaw, Katrin D. Mayer-Barber, Dragana Jankovic, Alan Sher, Clare M. Lloyd, Nicole Baldwin, Damien Chaussabel, Venizelos Papayannopoulos, Andreas Wack, Jacques F. Banchereau, Virginia M. Pascual, Anne O’Garra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lun
Externí odkaz:
https://doaj.org/article/2de9148c41624ebdb261719be7a52d90