Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jean Jasinski"'
Autor:
Georgia Fousteri, Maki Nakayama, Michael Croft, Yang Cheng, Matthias von Herrath, Florence Lambolez, Hilde Cheroutre, Amy Dave, George S. Eisenbarth, Philippe P. Pagni, Jean Jasinski, Therese Juntti, Ghanashyam Sarikonda
Publikováno v:
Diabetes. 61:1169-1179
In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (B:9-23) autoreactive CD4 T cells are key for initiating autoimmune diabetes in NOD mice; however, little is known regarding their origin and function.
Autor:
Henry A. Erlich, Andrea K. Steck, Janelle A. Noble, Jean Jasinski, Theresa A. Aly, Erin E. Baschal, George S. Eisenbarth
Publikováno v:
Clinical Immunology. 132:203-214
The availability of both HLA data and genotypes for thousands of SNPs across the major histocompatibility complex (MHC) in 1240 complete families of the Type 1 Diabetes Genetics Consortium allowed us to analyze the occurrence and extent of megabase c
Autor:
Maki Nakayama, Kelly Johnson, Bennett Davenport, Li Zhang, Masakazu Kobayashi, Jean Jasinski, George S. Eisenbarth, Howard W. Davidson, Kathryn Haskins
Publikováno v:
Journal of Autoimmunity. 33:42-49
Objective The objective of this study was to define the spectrum of TCR beta chains permissive for T cells with alpha chains containing the conserved TRAV5D-4*04 sequence to target the insulin B:9-23 peptide, a major epitope for initiation of diabete
Autor:
Ronald G. Gill, George S. Eisenbarth, Joshua Beilke, Maki Nakayama, Marcella Li, John F. Elliott, Jean Jasinski, Masakazu Kobayashi, Edwin Liu, Dongmei Miao, Marilyne Coulombe
Publikováno v:
Journal of Clinical Investigation. 117:1835-1843
NOD mice with knockout of both native insulin genes and a mutated proinsulin transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not develop diabetes. Transplantation of NOD islets, but not bone marrow, expressing native insulin
Autor:
Johanna Paronen, Maki Nakayama, George S. Eisenbarth, Jean Jasinski, Edwin Liu, Brooke Hensley, Dongmei Miao, Devasenan Devendra, Marcella Li, Evie Melanitou, Hiroaki Moriyama
Publikováno v:
Diabetes
Diabetes, American Diabetes Association, 2005, 54 (9), pp.2549-56. ⟨10.2337/diabetes.54.9.2549⟩
Diabetes, American Diabetes Association, 2005, 54 (9), pp.2549-56. ⟨10.2337/diabetes.54.9.2549⟩
International audience; A number of studies and clinical case reports have implicated interferon (IFN)-alpha as a potential mediator of type 1 diabetes pathogenesis. Administration of polyinosinic:polycytidylic acid (poly I:C), a mimic of viral doubl
Autor:
Jean Jasinski, George S. Eisenbarth
Publikováno v:
Endocrinology and Metabolism Clinics of North America. 33:59-73
Type 1A (immune-mediated) diabetes mellitus is now a predictable disorder, and its onset can be prevented or delayed in animal models with therapies that include the administration of islet autoantigens. To date, therapies that can delay but not prev
Autor:
Pamela R. Fain, Janet C. Siebert, Erin E. Baschal, Theresa A. Boyle, Jean Jasinski, George S. Eisenbarth
Publikováno v:
Journal of Translational Medicine, Vol 10, Iss 1, p 32 (2012)
Journal of Translational Medicine
Journal of Translational Medicine
Background Historically, extended haplotypes have been defined using only a few data points, such as alleles for several HLA genes in the MHC. High-density SNP data, and the increasing affordability of whole genome SNP typing, creates the opportunity
Autor:
George S. Eisenbarth, Jean Jasinski
Publikováno v:
Immunoendocrinology: Scientific and Clinical Aspects ISBN: 9781603274777
This book on immunoendocrinology deals primarily with autoimmune disorders. The study of endocrine autoimmune diseases has played a prominent role in advancing the understanding of autoimmunity including creation of the first models of induced auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdce03fd7b8780bdfa97be253e38d932
https://doi.org/10.1007/978-1-60327-478-4_1
https://doi.org/10.1007/978-1-60327-478-4_1
Autor:
Andrea K. Steck, Bernhard O. Boehm, Nunzio Bottini, Cécile Julier, Grant Morahan, J. X. She, Erin E. Baschal, Janelle A. Noble, George S. Eisenbarth, Patrick Concannon, Constantin Polychronakos, Jean Jasinski
Publikováno v:
Genes and immunity. 10
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is the third major locus affecting risk of type I diabetes (T1D), after HLA-DR/DQ and INS. The most associated single-nucleotide polymorphism (SNP), rs2476601, has a C->T variant and results
Autor:
Erin E. Baschal, Kelly Johnson, Jean Jasinski, Theresa A. Aly, Janelle A. Noble, Henry A. Erlich, Andrea K. Steck, George S. Eisenbarth
Publikováno v:
Diabetes, obesitymetabolism. 11
Aim: The goal of this study was to develop and implement methodology that would aid in the analysis of extended high-density single nucleotide polymorphism (SNP) major histocompatibility complex (MHC) haplotypes combined with human leucocyte antigen