Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

Autor: Patrick Midoux, Paul-Alain Jaffrès, Jean-Jacques Yaouanc, Chantal Pichon

Publikováno v: British Journal of Pharmacology. 157:166-178

DNA/cationic lipid (lipoplexes), DNA/cationic polymer (polyplexes) and DNA/cationic polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non-viral nucleic acids delivery systems. These DNA-nanoparticles are taken up by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec21219b2eb9ce8525b762cabd7e70dc
https://doi.org/10.1111/j.1476-5381.2009.00288.x

Factors mediating lipofection potency of a series of cationic phosphonolipids in human cell lines

Autor: Jean-Jacques Yaouanc, Dimitris Loukopoulos, J.‐C. Clement, Panagoula Kollia, Daphne Koumbi, Zili Sideratou

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2006, 1760 (8), pp.1151-1159. ⟨10.1016/j.bbagen.2006.03.005⟩

International audience; A series of cationic liposomes known as cationic phosphonolipids (CPs) were evaluated as vehicles for in vitro gene transfer in K562 erythroleukemia cells and 5637 epithelial carcinoma cells. For each CP and target cell type e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d1fddbf6eca19e90f3e2954886ff30
https://doi.org/10.1016/j.bbagen.2006.03.005

Hemilability of the primary amine–metal bond in polyamine-(Group 6) metal carbonyl complexes

Autor: Hervé des Abbayes, Jean-Claude Clément, Loïc Toupet, Anne-Cécile Hervé, Jean-Jacques Yaouanc

Publikováno v: Journal of Organometallic Chemistry. 664:214-222

A series of cis-LM(CO)4 complexes was prepared by reaction of non symmetrical diamines (L=R1R2N–(CH2)n–NH2, with R1 and R2=alkyl groups) with metal carbonyls M(CO)6, (M=Cr, Mo, W). Only the primary amine of these complexes reacted with mono or di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c9b8f69b7ec34075675556937d25d3e
https://doi.org/10.1016/s0022-328x(02)01992-7

Modes of complexation of bis-aminals of linear tetraamines with Group 6 metal carbonyls

Autor: Henri Handel, Gwénaëlle Hervé, Hélène Bernard, Nathalie Le Bris, Jean-Jacques Yaouanc, Hervé des Abbayes

Publikováno v: Journal of Organometallic Chemistry. 585:259-265

On reaction with Group 6 metal carbonyls M(CO)6, vic type bis-aminals L, issued from the condensation of an α-dicarbonyl compound on a linear tetraamine, give rise to mononuclear cis-M(CO)4L complexes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be19cef50977c2ec481cbea51211ab6a
https://doi.org/10.1016/s0022-328x(99)00232-6

Cationic Phosphonolipids as Nonviral Gene Transfer Agents in the Lungs of Mice

Autor: Jean-Jacques Yaouanc, J.P. Leroy, E Gobin, Claude Férec, Virginie Floch, J.‐C. Clement, Marie-Pierre Audrézet, Bernard Mercier, H. Des Abbayes, G Le Bolch, V Morin, C Guillaume-Gable

Publikováno v: Human Gene Therapy. 9:2309-2319

With the aim of developing new gene transfer tools for treating CF with gene therapy, we have synthesized a novel family of molecules named cationic phosphonolipids. The most efficient among them were selected by in vitro screening to compare their a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6656e3ad4131717285f91a3e25f5007
https://doi.org/10.1089/hum.1998.9.16-2309