Bispecific antibodies tethering innate receptors induce human tolerant-dendritic cells and regulatory T cells

Autor: Lucille Lamendour, Mäelle Gilotin, Nora Deluce-Kakwata Nkor, Zineb Lakhrif, Daniel Meley, Anne Poupon, Thibaut Laboute, Anne di Tommaso, Jean-Jacques Pin, Denis Mulleman, Guillaume Le Mélédo, Nicolas Aubrey, Hervé Watier, Florence Velge-Roussel

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

There is an urgent need for alternative therapies targeting human dendritic cells (DCs) that could reverse inflammatory syndromes in many autoimmune and inflammatory diseases and organ transplantations. Here, we describe a bispecific antibody (bsAb)

Externí odkaz: https://doaj.org/article/4b9e020bf8394fb091deb16ff1ee8765

Impact of Host Immune Status on Discordant Anti-SARS-CoV-2 Circulating B Cell Frequencies and Antibody Levels

Autor: Frédéric Coutant, Jean-Jacques Pin, Florence Morfin-Sherpa, Tristan Ferry, Stéphane Paul, Bruno Pozzetto, Myriam Normand, Pierre Miossec

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 20, p 11095 (2021)

Individuals with pre-existing chronic systemic low-grade inflammation are prone to develop severe COVID-19 and stronger anti-SARS-CoV-2 antibody responses. Whether this phenomenon reflects a differential expansion of antiviral B cells or a failure to

Externí odkaz: https://doaj.org/article/10aa34267575456ea087000b63c24c81

Monoclonal antibodies from B cells of patients with anti-MDA5 antibody-positive dermatomyositis directly stimulate interferon gamma production

Autor: Frédéric Coutant, Rafael Bachet, Jean-Jacques Pin, Marina Alonzo, Pierre Miossec

Publikováno v: Journal of autoimmunity. 130

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab) positive dermatomyositis (anti-MDA5 DM) is a rare entity associated with poor prognosis and multiple immunologic abnormalities. These include the presence of autoAbs and deleterious

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3af618867e759a88ffd5e6ba40212c
https://pubmed.ncbi.nlm.nih.gov/35436746

Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype

Autor: James Arthos, Diane Razanajaoana-Doll, Stephanie Laurant, Bernard Verrier, Claudia Cicala, Katija Jelicic, Alexandre Girard, Don Van Ryk, Nicolas Rochereau, Jean-Jacques Pin, Blandine Noailly, Christian Genin, Stéphane Paul

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 75:118-127

The homing of lymphocytes to the mucosa is mainly controlled by α4β7 integrin, and it is amplified during gut chronic inflammation, as occurs with HIV and/or inflammatory bowel diseases. We designed and applied an improved immunization strategy bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043a5591dfc5947ffa516813a7e5e55d
https://doi.org/10.1097/qai.0000000000001307

Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B

Autor: Diane Razanajaona-Doll, Céline Bressollette-Bodin, Flora Coulon, Martin Messerle, Stephanie Laurant, Vanessa Porkolab, Coraline Chéneau, Franck Fieschi, Jean-Jacques Pin, Eva Maria Borst, Franck Halary

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2018, 218 (3), pp.490-503. ⟨10.1093/infdis/jiy194⟩
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 2018, 218 (3), pp.490--503
Journal of Infectious Diseases, 2018, 218 (3), pp.490-503. ⟨10.1093/infdis/jiy194⟩

The envelope glycoprotein B of the human cytomegalovirus is a ligand for the lectin DC-SIGN. Here, the authors characterized this interaction at the molecular level. This should help to design new specific antiviral drugs.
Background Human cytom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cbd579d40e5931d297ce4411e12b0b
https://hal.univ-grenoble-alpes.fr/hal-01832776