Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Jean J Kim"'
Autor:
Jean J Kim, Jeffrey N Savas, Meghan T Miller, Xindao Hu, Cassiano Carromeu, Mathieu Lavallée-Adam, Beatriz C G Freitas, Alysson R Muotri, John R Yates, Anirvan Ghosh
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212553 (2019)
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality. Induced pluripotent stem cell (iPSC) li
Externí odkaz:
https://doaj.org/article/87e01bbb9e4e45acaf98802445390387
Generation of five induced pluripotent stem cell lines from patients with MECP2 Duplication Syndrome
Autor:
Danielle Mendonca, Gerarda Cappuccio, Jennifer Sheppard, Magdalena Delacruz, Jesse Bengtsson, Claudia M.B. Carvalho, Aleksandar Bajic, Hyekyung Park, Jean J. Kim, Paymaan Jafar-Nejad, Christine Coquery, Davut Pehlivan, Bernhard Suter, Mirjana Maletic-Savatic
Publikováno v:
Stem Cell Research, Vol 74, Iss , Pp 103292- (2024)
MECP2 Duplication Syndrome (MDS) is a rare, severe neurodevelopmental disorder arising from duplications in the Xq28 region containing the MECP2 gene that predominantly affects males. We generated five human induced pluripotent stem cell (iPSC) lines
Externí odkaz:
https://doaj.org/article/625ef611b6af4c16911e0f6c01beca7b
Autor:
Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel LaGrone, Jean J. Kim, Kevin R. MacKenzie, Allan Chris M. Ferreon, Choel Kim, Josephine C. Ferreon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA bind
Externí odkaz:
https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39fe
Autor:
Ayala Tovy, Carina Rosas, Amos S. Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M. Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E. Conneely, Anna G. Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J. Kim, Melissa T. Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M. John Hicks, Andrea N. Marcogliese, Margaret A. Goodell, Rachel E. Rau
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations
Externí odkaz:
https://doaj.org/article/6079e5ab657743e3ae91733b02a811e1
Autor:
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Publikováno v:
Nature Cell Biology. 25:528-539
Publikováno v:
Stem Cell Research, Vol 32, Iss , Pp 145-149 (2018)
Although the majority of late-onset Alzheimer's disease (AD) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the Apolipoprotein E (APOE) gene. Here, we
Externí odkaz:
https://doaj.org/article/1444ca730b154d22b21c99e031e5e39c
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 266-269 (2017)
Although the majority of late-onset Alzheimer's disease (AD) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the Apolipoprotein E (APOE) gene. Here, we
Externí odkaz:
https://doaj.org/article/579124967bcf4d73b82bd656c0ffe9a4
Publikováno v:
Biomarker Insights, Vol 2015, Iss Suppl. 1, Pp 133-137 (2015)
Externí odkaz:
https://doaj.org/article/c0e3232be2ab4941940ae337d22a897d
Autor:
Jean J. Kim
Publikováno v:
Biomarker Insights, Vol 2015, Iss Suppl. 1, Pp 125-131 (2015)
Externí odkaz:
https://doaj.org/article/ca3349fef06b4b82beaac229cc2a14aa
Autor:
Yung-Hsin Huang, Jean J Kim, Linda Zhang, Anne Gao, Margaret A. Goodell, M. John Hicks, Geraldo Medrano, Kristen Kurtz, Jaime M. Reyes, Amaia Lasa-Aranzasti, Chun-Wei Chen, Amos Gaikwad, Lionel Van Maldergem, Anna Guzman, Shannon E Conneely, Carina Rosas, Rogelio Aguilar, Tastuhiko Arakawa, Lorenzo Brunetti, Rachel E. Rau, Ayala Tovy, Melissa T. Carter, Andrea N. Marcogliese, Irene Valenzuela
Publikováno v:
Haematologica. 107:887-898
Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations