Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Jean J, Zhao"'
Autor:
Qiwei Wang, Johann S. Bergholz, Liya Ding, Ziying Lin, Sheheryar K. Kabraji, Melissa E. Hughes, Xiadi He, Shaozhen Xie, Tao Jiang, Weihua Wang, Jason J. Zoeller, Hye-Jung Kim, Thomas M. Roberts, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Deborah A. Dillon, Eric P. Winer, Nancy U. Lin, Jean J. Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
PARP inhibitor (PARPi) therapy has demonstrated only modest efficacy in advanced breast cancer with BRCA mutations. Here the authors show that, by suppressing PARPi-triggered DNA damage and reducing dsDNA production in BRCA1-deficient breast tumor ce
Externí odkaz:
https://doaj.org/article/6187b06c5a3643429f9e40f41b6a7bb5
Autor:
Jing Ni, Sheheryar Kabraji, Shaozhen Xie, Yanzhi Wang, Peichen Pan, Xiaofang He, Zongming Liu, Jose Palbo Leone, Henry W. Long, Myles A. Brown, Eric P. Winer, Deborah A. R. Dillon, Nancy U. Lin, Jean J. Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
HER2+ breast cancer often develop brain metastases (BCBMs) that are difficult to treat. Here, the authors show that p16INK4A loss in BCBMs from HER2+ breast tumors results in resistance to the HER2 inhibitor Tucatinib, and that CDK4/6 inhibition can
Externí odkaz:
https://doaj.org/article/16bc242049ff4c6ca1e0501ace504822
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite the impressive clinical response rate of osimertinib, a third-generation EGFR-TKI, as a frontline treatment for patients with EGFR-mutant non-small-cell lung cancer (NSCLC) or as a salvage therapy for patients with T790M mutation,
Externí odkaz:
https://doaj.org/article/22f0fafa89f4470d8c705527de7a45d5
Autor:
Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)
Background Poly (ADP-ribose) polymerase (PARP) inhibition (PARPi) has demonstrated potent therapeutic efficacy in patients with BRCA-mutant ovarian cancer. However, acquired resistance to PARPi remains a major challenge in the clinic.Methods PARPi-re
Externí odkaz:
https://doaj.org/article/84e48eba52e74658abc61bd3c1ea75b9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The CLOVES syndrome is an overgrowth disease arising from mosaic activating somatic mutations in the PIK3CA gene. These mutations occur during fetal development producing malformation and overgrowth of a variety of tissues. It has recently b
Externí odkaz:
https://doaj.org/article/761eb586c798462ba344c27fd5338111
Autor:
Johann S. Bergholz, Qiwei Wang, Qi Wang, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar Kabraji, Qian Zhou, G. Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J. Freeman, Hye-Jung Kim, Alex K. Shalek, Thomas M. Roberts, Jean J. Zhao
Publikováno v:
Nature. 617:139-146
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef1796b74c2ca0aff142f7d97454bd05
https://doi.org/10.1038/s41586-023-05940-w
https://doi.org/10.1038/s41586-023-05940-w
Autor:
Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick D. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien Tran, Sally Winther, Stephen M. Hinshaw, Jingnan Shen, Hyuk-Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Jean J. Zhao, Sirano Dhe-Paganon, Jianwei Che, Steven P. Gygi, Haribabu Arthanari, Edward T. Chouchani
Publikováno v:
Nature. 616:790-797
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fefca8c9ca13bceb27fbfc4d2e0b08ed
https://doi.org/10.1038/s41586-023-05939-3
https://doi.org/10.1038/s41586-023-05939-3
Publikováno v:
iScience, Vol 9, Iss , Pp 149-160 (2018)
Summary: The role of maternal and embryonic leucine zipper kinase (MELK) in cancer cell proliferation has been contentious, with recent studies arriving at disparate conclusions. We investigated the in vitro dependency of cancer cells on MELK under a
Externí odkaz:
https://doaj.org/article/7f6127a3823e4261a6df4a5ee57be8d0
Autor:
Jing Zhang, Xueliang Gao, Fabienne Schmit, Guillaume Adelmant, Michael J. Eck, Jarrod A. Marto, Jean J. Zhao, Thomas M. Roberts
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 549-557 (2017)
The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of
Externí odkaz:
https://doaj.org/article/3c7f2758514b4e9ca685e4628d81a820
Autor:
Sheheryar Kabraji, Jing Ni, Sarah Sammons, Tianyu Li, Amanda E.D. Van Swearingen, Yanzhi Wang, Alyssa Pereslete, Liangge Hsu, Pamela J. DiPiro, Chris Lascola, Heather Moore, Melissa Hughes, Akshara S. Raghavendra, Maria Gule-Monroe, Rashmi K. Murthy, Eric P. Winer, Carey K. Anders, Jean J. Zhao, Nancy U. Lin
Publikováno v:
Clin Cancer Res
Purpose: Brain metastases can occur in up to 50% of patients with metastatic HER2-positive breast cancer. Because patients with active brain metastases were excluded from previous pivotal clinical trials, the central nervous system (CNS) activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd732bc462df40bf3795d7807bf20c2f
https://doi.org/10.1158/1078-0432.ccr-22-1138
https://doi.org/10.1158/1078-0432.ccr-22-1138