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Synthesis and characterization of a d(ApG) platinated nonanucleotide duplex

Autor: Jean-Claude Chottard, Marie-Hélène Fouchet, Eric Guittet, Jean Igolen, Jean-Pierre Girault, C. Gauthier

Publikováno v: Biochemical and Biophysical Research Communications. 182:555-560

The nonamer 5'd(CTCAGCCTC) 3' 1 has been reacted with cis-diamminediaquaplatinum(II) in water at pH 4.2. The major reaction product was shown by enzymatic digestion and 1H NMR to be the d(ApG)cis-Pt(NH3)2 chelate [cis-Pt(NH3)2[d(CTCAGCCTC)-N7(4),N7(5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6cc9ca4d22a7b5edebea4e9e928cdf
https://doi.org/10.1016/0006-291x(92)91768-l

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Comparison of the bis-intercalating complexes formed between either ditercalinium or a flexible analogue and d(CpGpCpG)2 or d(TpTpCpGpCpGpApA)2 minihelices:1H- and31P-nmr analyses

Autor: Bernard P. Roques, Jean Igolen, Muriel Delepierre, Joël Pothier, Marie-Christine Barsi, Christiane Garbay-Jaureguiberry, Marc Le Bret

Publikováno v: Biopolymers. 31:1309-1323

The 400-MHz 1H- and 162-MHz 31P-nmr have been used to study complexes constituted by (a) the d(TpTpCpGpCpGpApA)2 or the d(CpGpCpG)2 self-complementary oligonucleotides and (b) two bifunctional 7H-pyrido [4,3-c] carbazole dimer drugs, the antitumoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d97cd5703623d654d49db09fae0f6d1
https://doi.org/10.1002/bip.360311109

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Characterization by FTIR spectroscopy of the oligoribonucleotide duplexes r(A-U)6 and r(A-U)8

Autor: Jean Liquier, T.Huynh Dinh, F. Ceolin, Jean Igolen, Eliane Taillandier, A. Akhebat

Publikováno v: Spectrochimica Acta Part A: Molecular Spectroscopy. 47:177-186

Fourier transform infrared spectroscopy has been used to characterize the helical conformation of double stranded oligoribonucleotides r(A-U)6 and r(A-U)8 in solution. As expected the oligoribonucleotides are found to adopt in solution an A family ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ab4297c0754734aa920cef4dc2d18ad
https://doi.org/10.1016/0584-8539(91)80089-2

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Synthesis of uridine and 2′-deoxyuridine mono- and tri-phosphates alkylated in position 5 by glycosides of α-D-mannose and N-acetyl-β-D-glucosamine: DNA and RNA monomers with tethered lectin targets

Autor: Jean Igolen, Jean-Michel Neumann, S. Robert Sarfati, Sylvie Pochet

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1065-1070

A simple synthesis of deoxyuridine and uridine 5′-mono- and 5′-tri-phosphates, C-5 alkylated by glycosides of 2-acetamido-2-deoxy-β-D-glucopyranose and α-D-mannopyranose, is reported. The glycosides (5) and (7) have been obtained respectively,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c396df3d40987a5d64ed8d52b0db5f0
https://doi.org/10.1039/p19900001065

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Polymorphism of the d(CCCGCGGG)2 double helix studied by FT-i.r. spectroscopy

Autor: W.L. Peticolas, S. Adam, Tam Huynh-Dinh, Jean Igolen, Eliane Taillandier

Publikováno v: Spectrochimica Acta Part A: Molecular Spectroscopy. 46:107-112

The deoxyoligonucleotide, d(CCCGCGGG), forms a duplex structure that can be put into the A and B forms in films by changing the ambient humidity and into the Z form by adding a heavy metal ion such as Ni(II). Since this oligomer contains only the bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5d97e9b3a57113581f5b855e976d4ae
https://doi.org/10.1016/0584-8539(93)80018-6

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Synthese de Tetrathymidylates Lies de Facon Covalente a des Derives de L'ellipticine

Autor: Tam Huynh-Dinh, Philippe Sizun, Claude Paoletti, Abdelkader Namane, Claudie Gautier, Jean Igolen

Publikováno v: Nucleosides and Nucleotides. 9:1-19

Tetrathymidylate has been covalently linked at its 3′ extremity to ellipticine derivatives (9-hydroxy-N-2-methylellipticinium acetate 1 or 9-hydroxyellipticine 2) via a ω-aminoacyl arm. The synthesis consists of two steps: esterification of the ol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2322ddbc119a538f883761d5f865458
https://doi.org/10.1080/07328319008045105

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Conformational Studies by 1H NMR of the HIV Enhancer: the Transcription Factors NF‐κB and Sp1 Binding Domains

Autor: Abdelkader Namane, Muriel Delepierre, Patrick Sodano, Jean Igolen, Jean-Louis Virelizier, Catherine Gouyette

Publikováno v: Magnetic Resonance in Chemistry
Magnetic Resonance in Chemistry, Wiley, 1996, 34 (13), pp.S67-S80. ⟨10.1002/(SICI)1097-458X(199612)34:133.0.CO;2-F⟩
Magnetic Resonance in Chemistry, 1996, 34 (13), pp.S67-S80. ⟨10.1002/(SICI)1097-458X(199612)34:133.0.CO;2-F⟩

International audience; The solution structures of two DNA non-palindromic duplexes of 24 base pairs and corresponding to the 3 NF-B-binding site and the adjacent 5 Sp1-binding site of the HIV-1 long terminal repeat (5LTR) were analyzed by proton two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2697d8004150ec95fb6c776173a84d
https://hal-pasteur.archives-ouvertes.fr/pasteur-00376433

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Molecular structure of a complete turn of A-DNA

Autor: Miquel Coll, Tam Huynh-Dinh, Núria Verdaguer, Dolors Fernández-Forner, Juan A. Subirana, Jean Igolen, Ignacio Fita, Joan Aymamí

Publikováno v: Scopus-Elsevier
Digital.CSIC. Repositorio Institucional del CSIC
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We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389ff0de52a920bbf37101bb16f6c06a
http://hdl.handle.net/10261/111131

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